CLINICAL EXPERIENCES USING THE ANTIVIRAL 1‐β‐D‐RIBOFURANOSYL‐1,2,4‐TRIAZOLE‐3‐CARBOXAMIDE (RIBAVIRIN) IN MEXICO

Abstract

Follow-up of the use of ribavirin in 390 human patients in Mexico indicates the drug has been used to treat a variety of virus infections. No toxic manifestations of the drug were reported, and the subjective results suggest possible antiviral efficacy. A double-blind, placebo-controlled study using topically applied 5% ribavirin in ointment base against herpes zoster in cancer patients indicates definite efficacy against this specific disease.

Synthesis and antihypertensive activity of some ester progenitors of methyldopa

“…A mixture of 2a (175 g, 0.425 mol), Me2CO (1750 mL), and H20 (1750 mL) was stirred under N2 at a temperature below 10 °C while the pH was adjusted to 12.0 by the slow addition of 10% NaOH. Carbobenzyloxy chloride (93 g, 0.545 mol) was added dropwise over 5-7 min to the reaction mixture at [20][21][22][23][24][25][26][27][28][29][30] °C, accompanied by the simultaneous addition of sufficient 10% NaOH solution to maintain a pH of 12.0-12.2. After addition of the carbobenzyloxy chloride was complete, the reaction mixture was stirred at 25 -30 °C for an additional 3 h. Most of the Me2CO was then removed under reduced pressure at 25-35 °C to precipitate the sodium salt of the desired IV-carbobenzyloxy derivative.…”