Clinical Experience with N-butyl Cyanoacryiate (Nexacryl) Tissue Adhesive

Leahey, Alan B.; Gottsch, John D.; Stark, Walter J.

doi:10.1016/s0161-6420(93)31674-x

Cited by 134 publications

(86 citation statements)

References 39 publications

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“…Nowadays, the most used surgical adhesives are based on fibrin [3,4] and cyanoacrylates [5,6]. The fibrin based adhesives present several problems, e.g.…”

Section: Introductionmentioning

confidence: 99%

Modification of the biopolymer castor oil with free isocyanate groups to be applied as bioadhesive

Ferreira

Pereira

Coelho

et al. 2007

International Journal of Biological Macromolecules

133

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Surgical adhesives have been used for several applications, including haemostasis, sealing air leakages and tissue adhesion. The aim of this work was to develop a biodegradable urethane-based bioadhesive containing free isocyanate groups. This material presents the advantage of being biodegradable, biocompatible and having the capacity of reacting with amino groups present in the biological molecules.A urethane based on castor oil (CO) was synthesized by reaction of the molecule with isophorone diisocyanate (IPD). The characterization of the material was accomplished by different techniques: ATR-FT-IR (attenuated transmittance reflection-Fourier transform infrared), swelling capacity determination, evaluation of the moisture curing kinetics, reaction with aminated substrates and determination of surface energy by contact angle measurement. The study of the urethane thermal properties was performed by DMTA (dynamical mechanical thermal analysis) and TGA (thermogravimetric analysis). The haemocompatibility of the urethane was also evaluated by thrombosis and haemolysis tests.

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“…Nowadays, the most used surgical adhesives are based on fibrin [3,4] and cyanoacrylates [5,6]. The fibrin based adhesives present several problems, e.g.…”

Section: Introductionmentioning

confidence: 99%

Modification of the biopolymer castor oil with free isocyanate groups to be applied as bioadhesive

Ferreira

Pereira

Coelho

et al. 2007

International Journal of Biological Macromolecules

133

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“…Treatment options for corneal melt and perforations include medical therapy of underlying diseases and; simple measures such as BCL, corneal gluing, and tarsorrhaphy. 21 If these methods fail, then authors have described the use of conjunctival flaps, 22 AMT, 23 lamellar keratoplasty (LK), 24 deep lamellar keratoplasty (DLK), 25 patch graft, 12 or PKP. 18,19 Tissue adhesives can be used to close small perforation (up to 3 mm in diameter) and may slow down stromal melting.…”

Section: Discussionmentioning

confidence: 99%

“…18,19 Tissue adhesives can be used to close small perforation (up to 3 mm in diameter) and may slow down stromal melting. 21,26 Although Leahey et al 21 in a series of 44 patients (3 children) used cyanoacrylate glue to treat perforations, 2 children needed a subsequent conjunctival flap and PKP, resulting in poor visual outcome (see Table 3). We used histoacrylate glue and BCL in case 2 (Figure 2a), but the aggressive inflammatory reaction with a non-healing perforation prompted a therapeutic PKP immediately (Figures 2b and c).…”

Section: Discussionmentioning

confidence: 99%

Management of inflammatory corneal melt leading to central perforation in children: a retrospective study and review of literature

Medsinge

Gajdošová

Moore

et al. 2016

Eye

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Purpose To assess the outcome of early therapeutic penetrating keratoplasty (PKP) for corneal melt leading to perforation in children.Methods Case notes of all the consecutive patients presenting with acute corneal perforation that underwent urgent therapeutic PKP between 2000 and 2010 to the practice of one of the authors, both NHS at Great Ormond Street Hospital for Children and private, were retrospectively reviewed. Onset of perforation, underlying cause, medical and surgical treatment, pre-and post-operative visual acuity, graft clarity, length of followup, and post-operative complications were recorded. Results Four eyes of four consecutive patients (mean age of 9.5 years and median 8.5 years, range 4-17 years) were treated for acquired acute onset corneal perforations. There were three females and one male.

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“…Also, an adhesive would ideally present the ability to cure in a moist environment. Among the adhesives available on the market, the most applied are the ones based either on fibrin (Silver et al, 1995;Dunn & Goa, 1999) or cyanoacrylates (Leahey et al, 1993;King & Kinney, 1999). Both classes present some advantages as well as some disadvantages.…”

Section: Bioadhesivesmentioning

confidence: 99%