Clinical experience with low dosage of propionohydroxamic acid (PHA) in infected renal stones

Struvite Calculi

“…All side effects reversed upon cessation of AHA and no attributable deaths were recorded. Propionohydroxamic acid (PHA) has been used less extensively in patients but has been associated with few side effects (Martelli et al, 1986).…”

Encrusted Uropathy: A Comprehensive Overview—To the Bottom of the Crust

“…Additionally, the compound is proven to be teratogenic in animals (109,110), requiring effective contraception in females of childbearing age. Alternatively, although less effective, propionohydroxamic acid (111,112), ammonium chloride (6,113), vitamin C (11), cranberry juice (75), and hydroxyurea (114) have been used as oral acidifying agents. Finally, the effectiveness of L-methionine for long-term oral urinary acidification has very recently been reported in one case of encrusted uropathy by Sabiote et al (115).…”