Clinical Experience With a Mobile Ocular Perfusion Pump

Use of Autologous Serum in the Treatment of Ocular Surface Disorders

“…1 Subsequently, a report 2 in the rheumatologic literature appeared in 1984 discussing the use of autologous serum as a tear substitute. Although probably used more often than it was publicized to be, the use of autologous serum for the treatment of ocular surface disorder did not appear to garner widespread interest until the late 1990s ( Figure).…”

Human Albumin Eye Drops as a Therapeutic Option for the Mmanagement of Keratoconjunctivitis Sicca Secondary to Chronic Graft-Versus-Host Disease after Stem-Cell Allografting

“…Historically, application of autologous serum to the eyes began in 1975 with the use of an intermittently administered mobile profusion pump for 12 patients suffering from severe dry eye 25 . Patients could carry the pump with them wherever they went, giving them mobility.…”

“…Patients could carry the pump with them wherever they went, giving them mobility. Since the late 1990s, autologous serum for ophthalmic treatment has been more widely used 25 . Common indications for its use are ocular surface disorders such as Sjögren syndrome 27 .…”

“…Other potential roadblocks, such as the needs for good manufacturing practices, licenses for serum preparation, protocol optimization and standardization, and cost and inconvenience to patients were discussed by Ralph and colleagues 25 . One case report 33 detailed the use of allogeneic serum albumin donated from close relatives as an option for kcs treatment.…”

Clinical Administration of Ocular Drugs

“…Depending on the system and on the drugs perfused, complications have included infection, crystallization and sludging of the drug within the tubing, and slippage of the tubing. 99 Animal experiments suggest that implantable pumping devices may have practical application in the delivery of drugs to the eye. In some systems the implanted fluid reservoir can be refilled by a percutaneous injection through a self-sealing rubber septum, thus circumventing the inconvenience of carrying an exposed pump.…”