CLINICAL EXPERIENCE WITH 99mTc-HEXAMETHYLPROPYLENE-AMINEOXIME FOR LABELLING LEUCOCYTES AND IMAGING INFLAMMATION

Peters, A. M.; Osman, Safiye; Henderson, B. L.; Kelly, John D.; Danpure, H. J.; Hawker, R J; Hodgson, H. J. F.; Neirinckx, R.D.; Lavender, J. P.

doi:10.1016/s0140-6736(86)90601-x

Cited by 311 publications

(129 citation statements)

References 9 publications

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“…In nuclear medicine, they are typically labeled with 111 In-oxime or 99 Tcm. [13][14][15] Contrast agents (CAs) are available for NMR imaging. Two main classes of CAs are commonly used for clinical diagnostic MRI: the lanthanide-based paramagnetic complexes and the superparamagnetic iron oxide particles (SPIOs).…”

Section: Introductionmentioning

confidence: 99%

Discrepancies between the fate of myoblast xenograft in mouse leg muscle and NMR label persistency after loading with Gd-DTPA or SPIOs

et al. 2009

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Section: Introductionmentioning

confidence: 99%

Discrepancies between the fate of myoblast xenograft in mouse leg muscle and NMR label persistency after loading with Gd-DTPA or SPIOs

et al. 2009

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“…A standard technique was used for the labeling of circulating leucocytes with 99m Tc-HMPAO (Peters, 1986). The allergen extracts used in the patients with subcutaneous immunotherapy (aqueous and depot) or submitted to sublingual Dermatophagoides pteronyssinus treatment were produced by the ALK-Abelló Laboratory (Madrid, Spain).…”

Section: Methodology For This Studymentioning

confidence: 99%

“…In these studies, the administration of the allergen extract, according to the maintenance scheme in place for each patient, would occur simultaneously with the reinjection of leucocytes labeled with 99m Tc-HMPAO. The labeling of leucocytes with 99m Tc-HMPAO is a technique that, on the theoretical level, has affinity for all the cellular elements of the white series (mononuclear and polymorphonuclear) and all of these have a specific contribution in the inflammatory process (Kumar, 2005;Peters, 1986). The therapeutic allergenic extract injections always induce an inflammatory reaction at the local of the administration, detectable clinically by the presence of typical local signals.…”

Section: Dynamics Of the Immunotherapy Mechanismmentioning

confidence: 99%

Specific Immunotherapy and Central Immune System

Pereira¹,

Loureiro²,

Tavares³

et al. 2012

Allergic Diseases - Highlights in the Clinic, Mechanisms and Treatment

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“…We then went on to develop Tc-99m-HMPAO for leucocyte labelling [ 28 ]. Saverymuttu demonstrated the extraordinary ability of In-111 and Tc-99m-labelled leucocyte scintigraphy to quantify and image infl ammatory bowel disease (Fig.…”

mentioning

confidence: 99%

Nuclear Medicine at the Hammersmith Hospital

Peters

2016

A History of Radionuclide Studies in the UK

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Nuclear medicine at the Hammersmith Hospital was established as a separate unit by Peter Lavender in the early seventies. It was called the Radioisotope Unit to distinguish it from the pre-existing Department of Medical Physics, headed by Harold Glass who was one of the early pioneers in medical radioisotope scanners [ 1 ]. As well as providing a clinical service, the unit, which only comprised two rooms, was active in clinical research complemented by the extensive academic activities of the MRC Cyclotron Unit. Two good examples of these activities that launched nuclear medicine at Hammersmith are fi rstly the development by Clark, Watson Fazio and Jones of Kr-81m for ventilation and perfusion studies [ 2 ], and secondly, cell labelling.Kr-81m is a 13 s half-life radionuclide that is the metastable daughter of Rb-81, which has a half-life of 4.7 h. To obtain Kr-81m gas, oxygen is passed through the generator. There was an enthusiastic response to the generator across the UK, and, at one point, Kr-81m/Tc-99m ventilation/perfusion imaging was the second most frequently performed imaging procedure in the UK after bone scanning. Whilst Kr-81m remains the optimal ventilation agent for lung scanning, it is not so widely appreciated that Lavender and his colleagues also administered Kr-81 in solution to measure tissue perfusion. To obtain Kr-81m in solution, isotonic glucose is passed through the generator. For example, Harvey-Turner and Selwyn infused Kr-81m into the aortic root of dogs and continuously imaged regional changes in myocardial perfusion in response to transient coronary artery occlusion [ 3 ]. The distribution of pulmonary blood fl ow in humans was also imaged by continuous intravenous infusion [ 4 ]. Kr-81m was given both by inhalation and infusion to study ventilationperfusion ratios and regional lung function in adults [ 4 , 5 ] and children [ 6 ], When combined with the longer half-life Kr-85 (a lung gas volume marker), regional lung

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CLINICAL EXPERIENCE WITH 99mTc-HEXAMETHYLPROPYLENE-AMINEOXIME FOR LABELLING LEUCOCYTES AND IMAGING INFLAMMATION

Cited by 311 publications

References 9 publications

Discrepancies between the fate of myoblast xenograft in mouse leg muscle and NMR label persistency after loading with Gd-DTPA or SPIOs

Discrepancies between the fate of myoblast xenograft in mouse leg muscle and NMR label persistency after loading with Gd-DTPA or SPIOs

Specific Immunotherapy and Central Immune System

Nuclear Medicine at the Hammersmith Hospital

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