Clinical Experience Using Cortoss for Treating Vertebral Compression Fractures With Vertebroplasty and Kyphoplasty

Bae, Hyun; Shen, Michael; Maurer, Philip; Peppelman, Walter; Beutler, William; Linovitz, Raymond; Westerlund, Erik; Peppers, Timothy; Lieberman, Isador H.; Kim, Choll; Girardi, Federico P.

doi:10.1097/brs.0b013e3181dcda75

Cited by 39 publications

(28 citation statements)

References 34 publications

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“…Additionally in the VP group the authors reported one psoas hematoma, one injury to the thecal sac (managed conservatively [21]), and one osteomyelitis requiring further surgery [22]. No cases of symptomatic cement extravasation were reported in the BKP arm, while one case of osteomyelitis was recorded [69]. The only study describing SAEs in detail was the FREE trial [8] (BKP vs. NSM randomized) where the profile was similar in both groups: 58 events in 149 cases in the BKP arm and 54/151 in the NSM arm.…”

Section: Serious Adverse Eventsmentioning

confidence: 98%

Comparing effects of kyphoplasty, vertebroplasty, and non-surgical management in a systematic review of randomized and non-randomized controlled studies

et al. 2012

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Purpose To determine if differences in safety or efficacy exist between balloon kyphoplasty (BKP), vertebroplasty (VP) and non-surgical management (NSM) for the treatment of osteoporotic vertebral compression fractures (VCFs). Methods As of February 1, 2011, a PubMed search (key words: kyphoplasty, vertebroplasty) resulted in 1,587 articles out of which 27 met basic selection criteria (prospective multiple-arm studies with cohorts of C20 patients).This systematic review adheres to preferred reporting items for systematic reviews and meta-analyses (PRISMA) guidelines.Results Pain reduction in both BKP (-5.07/10 points, P \ 0.01) and VP (-4.55/10, P \ 0.01) was superior to that for NSM (-2.17/10), while no difference was found between BKP/VP (P = 0.35). Subsequent fractures occurred more frequently in the NSM group (22 %) compared with VP (11 %, P = 0.04) and BKP (11 %, P = 0.01). BKP resulted in greater kyphosis reduction than VP (4.88 vs. 1.7°, P \ 0.01). Quality of life (QOL) improvement showed superiority of BKP over VP (P = 0.04), along with a trend for disability improvement (P = 0.08). Cement extravasation was less frequent in the BKP (P = 0.01). Surgical intervention within the first 7 weeks yielded greater pain reduction than VCFs treated later. Conclusions BKP/VP provided greater pain relief and fewer subsequent fractures than NSM in osteoporotic VCFs. BKP is marginally favored over VP in disability improvement, and significantly favored in QOL improvement. BKP had a lower risk of cement extravasation and resulted in greater kyphosis correction. Despite this analysis being restricted to Level I and II studies, significant heterogeneity suggests that the current literature is delivering inconsistent messages and further trials are needed to delineate confounding variables.

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Section: Serious Adverse Eventsmentioning

confidence: 98%

Comparing effects of kyphoplasty, vertebroplasty, and non-surgical management in a systematic review of randomized and non-randomized controlled studies

et al. 2012

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“…10 Bis-GMA composites were first used as synthetic bone void fillers in vertebral and long bone augmentation procedures and were found to be advantageous over other allografts in animal and clinical studies. [12][13][14][15] Their mechanical advantages, ease of application, and successful clinical results make them popular in operating theaters. 10,16 Biomechanical characteristics of bis-GMA-based materials in the living tissue were evaluated in only 1 animal study, which was conducted in long bones of rabbits and sheep.…”

mentioning

confidence: 99%

Osteointegration of a Bisphenol-a-Glycidyl-Dimethacrylate Composite and Its Use in Anterior Skull Base Defects

Sanuş¹,

Küçükyürük

Biçeroğlu

et al. 2014

Journal of Craniofacial Surgery

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“…107,108 Cortoss (Orthovita) contains bioactive glass and has been successfully used in kyphoplasty and vertebroplasty as well as spinal fusion. [43][44][45] Collagen and collagen/HA. Collagen is an osteoconductive material and when used alone provides minimal structural support as a bone graft substitute, which limits its use clinically.…”

Section: Resultsmentioning

confidence: 99%

Bone graft substitutes currently available in orthopaedic practice

Kurien

Pearson

Scammell

2013

The Bone & Joint Journal

196

168

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We reviewed 59 bone graft substitutes marketed by 17 companies currently available for implantation in the United Kingdom, with the aim of assessing the peer-reviewed literature to facilitate informed decision-making regarding their use in clinical practice. After critical analysis of the literature, only 22 products (37%) had any clinical data. Norian SRS (Synthes), Vitoss (Orthovita), Cortoss (Orthovita) and Alpha-BSM (Etex) had Level I evidence. We question the need for so many different products, especially with limited published clinical evidence for their efficacy, and conclude that there is a considerable need for further prospective randomised trials to facilitate informed decision-making with regard to the use of current and future bone graft substitutes in clinical practice.

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Clinical Experience Using Cortoss for Treating Vertebral Compression Fractures With Vertebroplasty and Kyphoplasty

Abstract: These studies indicate Cortoss is safe and effective in treating osteoporotic VCF using vertebroplasty or kyphoplasty. Pain relief and restoration of function with Cortoss is comparable to results found in the literature for polymethylmethacrylate.

Cited by 39 publications

References 34 publications

Comparing effects of kyphoplasty, vertebroplasty, and non-surgical management in a systematic review of randomized and non-randomized controlled studies

Comparing effects of kyphoplasty, vertebroplasty, and non-surgical management in a systematic review of randomized and non-randomized controlled studies

Osteointegration of a Bisphenol-a-Glycidyl-Dimethacrylate Composite and Its Use in Anterior Skull Base Defects

Bone graft substitutes currently available in orthopaedic practice

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