Bone graft substitutes currently available in orthopaedic practice

Kurien, Thomas; Pearson, Roberta; Scammell, Brigitte E.

doi:10.1302/0301-620x.95b5.30286

Cited by 192 publications

(178 citation statements)

References 116 publications

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“…For the 8-week time point, sample sizes were: uncoated (9), DGEA (6), E7DGEA (6), BMP2pep (8), E7BMP2pep (8), rBMP2 (9), and SHAM (5). For the 12-week time point, sample sizes were: uncoated (7), DGEA (6), E7DGEA (6), BMP2pep (8), E7BMP2pep (8), rBMP2 (9), and SHAM (4). For each time point, the ratio of 18 F-NaF activity in the defect area was calculated as a ratio to the 18 F-NaF activity in the reference area for each animal.…”

Section: Resultsmentioning

confidence: 99%

“…Processed allografts retain their osteoconductive properties, but lose any osteogenic, and most osteoinductive, potential. 9 Moreover, the osteoinductivity of allograft depends on the age and other factors related to the donor at the time of harvest. 10 Xenograft and alloplast materials offer other alternatives to autogenous bone, but these are also processed or manufactured in a way that leaves them devoid of organic components.…”

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confidence: 99%

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Enhancement of the Regenerative Potential of Anorganic Bovine Bone Graft Utilizing a Polyglutamate-Modified BMP2 Peptide with Improved Binding to Calcium-Containing Materials

Bain

Bonvallet

Abou‐Arraj

et al. 2015

Tissue Engineering Part A

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Autogenous bone is the gold standard material for bone grafting in craniofacial and orthopedic regenerative medicine. However, due to complications associated with harvesting donor bone, clinicians often use commercial graft materials that may lose their osteoinductivity due to processing. This study was aimed to functionalize one of these materials, anorganic bovine bone (ABB), with osteoinductive peptides to enhance regenerative capacity. Two peptides known to induce osteoblastic differentiation of mesenchymal stem cells were evaluated: (1) DGEA, an amino acid motif within collagen I and (2) a biomimetic peptide derived from bone morphogenic protein 2 (BMP2pep). To achieve directed coupling of the peptides to the graft surface, the peptides were engineered with a heptaglutamate domain (E7), which confers specific binding to calcium moieties within bone mineral. Peptides with the E7 domain exhibited greater anchoring to ABB than unmodified peptides, and E7 peptides were retained on ABB for at least 8 weeks in vivo. To assess the osteoinductive potential of the peptide-conjugated ABB, ectopic bone formation was evaluated utilizing a rat subcutaneous pouch model. ABB conjugated with full-length recombinant BMP2 (rBMP2) was also implanted as a model for current clinical treatments utilizing rBMP2 passively adsorbed to carriers. These studies showed that E7BMP2pep/ABB samples induced more new bone formation than all other peptides, and an equivalent amount of new bone as compared with rBMP2/ABB. A mandibular defect model was also used to examine intrabony healing of peptide-conjugated ABB. Bone healing was monitored at varying time points by positron emission tomography imaging with 18 F-NaF, and it was found that the E7BMP2pep/ABB group had greater bone metabolic activity than all other groups, including rBMP2/ABB. Importantly, animals implanted with rBMP2/ABB exhibited complications, including inflammation and formation of cataract-like lesions in the eye, whereas no side effects were observed with E7BMP2pep/ABB. Furthermore, histological analysis of the tissues revealed that grafts with rBMP2, but not E7BMP2pep, induced formation of adipose tissue in the defect area. Collectively, these results suggest that E7-modified BMP2-mimetic peptides may enhance the regenerative potential of commercial graft materials without the deleterious effects or high costs associated with rBMP2 treatments.

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Section: Resultsmentioning

confidence: 99%

mentioning

confidence: 99%

Enhancement of the Regenerative Potential of Anorganic Bovine Bone Graft Utilizing a Polyglutamate-Modified BMP2 Peptide with Improved Binding to Calcium-Containing Materials

Bain

Bonvallet

Abou‐Arraj

et al. 2015

Tissue Engineering Part A

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“…Zudem wurde eine Druckfestigkeit ermittelt, die nach ca. 48 h der des spongiösen Knochen entsprechen soll [50].…”

Section: Characteristicsunclassified

Knochenersatzwerkstoffe als lokale Wirkstoffträger

2017

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“…For example, Acticoat™ and Algisite™ are patches for wound dressing based on antibacterial silver nanoparticles (Smith and Nephew, 2014). For products loaded instead with calcium phosphate or hydroxyapatite (HA) nanoparticles, Ostim™[Osartis, Germany (Doessel and Schlegel, 2010)], Vitoss™[Orthovita, USA (Kurien et al, 2013)], and NanOss™[Angstrom Medica, USA (Roveri and Iafisco, 2010)] can be mentioned, which have been launched in recent years as synthetic bone graft substitutes. For specific dental applications, some HA coatings of dental implants have also been introduced [e.g., Spline Twist MP-1™ by Zimmer (2014), USA], but generally without much success probably due to delamination effects at the interface with the Ti alloy implant core.…”

Section: Implant Surface Functionalizationmentioning

confidence: 99%

Dentistry on the Bridge to Nanoscience and Nanotechnology

Salerno

Diaspro

2015

Front. Mater.

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Dentistry is the area of medical sciences that is most resistant to the introduction of the novel methods arisen from the development of nanoscience and nanotechnology in the last 20 years. Without moving on to science-fiction-like views pointing to times far ahead in the future, we show that the available nanoscale devices and processes of current science and technology, partly inherited from the areas of microscopy and microelectronics, have already proven to be useful for research and development in different fields of dental research. To this goal, we review some results obtained in the last few years at our Institute in the area of dental materials and their characterization, which showed successful application of our background in microscopy and nanoengineering.Keywords: dental materials, microscopy, surface roughness, nanofabrication, resin composites, implants THE BROAD SCOPE OF DENTISTRYDentistry is considered to be a branch of medicine, such as orthopedics or physiology or neurology. In fact, while based on common foundations of medicine, dentistry is a large stand-alone area, which has its own grasps to the different fields mentioned above (American Dental Association, 2014). For example, topics of periodontal ligament health and dental implant osteointegration clearly relate to a peculiar "dental orthopedics"; the fact that teeth are not a mineralized appendix but rather a living organ in a living environment (gingiva, oral liquids) involves a specific "dental physiology"; the sensitivity of the living tooth, in connection with the pulp and related nerves, can be associated to a possible "dental neurology." Indeed, the oral environment, which is the place where dental functions are operated, is one of the most complex ones in the human body.As a result, within the dental area several specialized disciplines exist (see Figure 1). Conservative dentistry aims to maintain the original denture and largely overlaps with restorative dentistry, the latter encompassing prosthodontics, periodontics, and endodontics. Prosthodontics (or prosthetic dentistry) is required in case of massive irreversible tooth damage that cannot be fixed with simple resin composite filling, and requires the use of prosthesis for teeth, namely crowns, bridges, and even whole dentures. Periodontics (or periodontology) addresses the diseases of the periodontum, i.e., the teeth ligaments. Endodontics focuses on therapy of the root canals and connected pulp diseases. Oral surgery relates to the extraction of teeth that cannot be saved anymore and should be replaced by implants, and is usually combined with maxillo-facial surgery, extending the treated area around the denture. Prosthodontics, periodontics, and surgery correlate to implantology, which deals with the installation of dental implants. Orthodontics concerns the alignment and straightening of teeth, as well as fixing midface and mandibular growth issues. Pedodontics (or pediatric dentistry) relates to the specific dental issues of children's temporary dentures. Of course, oral...

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Bone graft substitutes currently available in orthopaedic practice

Cited by 192 publications

References 116 publications

Enhancement of the Regenerative Potential of Anorganic Bovine Bone Graft Utilizing a Polyglutamate-Modified BMP2 Peptide with Improved Binding to Calcium-Containing Materials

Enhancement of the Regenerative Potential of Anorganic Bovine Bone Graft Utilizing a Polyglutamate-Modified BMP2 Peptide with Improved Binding to Calcium-Containing Materials

Knochenersatzwerkstoffe als lokale Wirkstoffträger

Dentistry on the Bridge to Nanoscience and Nanotechnology

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