Clinical Examination of the Water-Soluble Vitamin Levels in Blood during Peripheral Parenteral Nutrition

Ozasa, Hiroyuki; Ishibashi, Nobuya; Ikeda, Satoru; Imaizumi, T; Miyagi, Motoshi; Yano, Shoichiro; Aoyagi, Keishiro; Akagi, Yoshito; Osuga, Yutaka; Shirouzu, Kazuo

doi:10.2739/kurumemedj.53.79

Cited by 6 publications

(8 citation statements)

References 15 publications

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“…Some investigators have shown preoperative nutrition status to be poor in patients who develop TD. 7,15 However, in our study, the pediatric patients' preoperative nutrition status, including the thiamine blood concentrations, was adequate. In addition, during the postoperative period requiring PPN, thiamine concentrations gradually decreased with time when the PPN solution did not include thiamine.…”

Section: Discussioncontrasting

confidence: 49%

“…When PPN is selected after abdominal surgery in children, excluding major surgery requiring extended PN, clinicians do not routinely monitor thiamine blood concentrations. 15 This may be because TD is not thought to occur during PPN. In this study, the chronological change of thiamine blood concentrations was investigated during the postoperative period after abdominal surgery in children receiving PPN in order to clarify the necessity of thiamine administration in PPN.…”

Section: Discussionmentioning

confidence: 99%

“…19 A gradual decrease in thiamine blood concentrations after gastrointestinal surgery in adult patients during the PPN period has been reported. 15 However, in children, it is unclear whether the addition of thiamine to PPN solution after abdominal surgery is required.…”

Section: Discussionmentioning

confidence: 99%

“…In addition, during the postoperative period requiring PPN, thiamine concentrations gradually decreased with time when the PPN solution did not include thiamine. 15 In general, the total body store of thiamine is known to be lower than that of other vitamins. 20 In addition, the requirement per body weight in infants or younger children is thought to be larger than that in older children or adults attributable to rapid metabolic activity, growth, and other biological activities.…”

Section: Discussionmentioning

confidence: 99%

“…There are few reports regarding the change of blood thiamine concentrations during the postoperative period in patients receiving peripheral parenteral nutrition (PPN) without a high concentration of glucose and no thiamine. 15 In addition, no data are available regarding the change in blood thiamine concentrations during the starvation period after surgery in children, especially infants and younger children. Furthermore, the necessity for thiamine administration after surgery has not been fully studied in pediatric patients receiving PPN.…”

Section: Original Communicationmentioning

confidence: 99%

See 4 more Smart Citations

Need for Thiamine in Peripheral Parenteral Nutrition After Abdominal Surgery in Children

Masumoto

Esumi

Teshiba

et al. 2009

J Parenter Enteral Nutr

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Section: Discussioncontrasting

confidence: 49%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Original Communicationmentioning

confidence: 99%

See 3 more Smart Citations

Need for Thiamine in Peripheral Parenteral Nutrition After Abdominal Surgery in Children

Masumoto

Esumi

Teshiba

et al. 2009

J Parenter Enteral Nutr

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Adequacy of vitamin C supplementation in patients with gastrointestinal disorders receiving parenteral nutrition: A randomized trial

Kuwabara¹,

Goseki²,

Nakamura³

et al. 2011

e-SPEN, the European e-Journal of Clinical Nutrition and Metabo

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The effects of surgery on plasma/serum vitamin C concentrations: a systematic review and meta-analysis

et al. 2020

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Vitamin C (ascorbic acid) is a water soluble vitamin with an array of biological functions. A number of proposed factors contribute to the vitamin’s plasma bioavailability and ability to exert optimal functionality. The aim of this review was to systematically assess plasma vitamin C levels post-surgery compared with pre-surgery/ the magnitude and timeframe of potential changes in concentration. We searched the PUBMED, SCOPUS, SciSearch and the Cochrane Library databases between 1970 to April 2020 for relevant research papers. Prospective studies, control groups and true placebo groups derived from controlled trials that reported means and standard deviations of plasma vitamin C concentrations pre and post operatively were included into the meta-analysis. Data were grouped into short-term (≤7 days) and long term (> 7 days) post-operative follow-up. 23 of 31 studies involving 642 patients included in the systematic review were suitable for meta-analysis. Pooled data from the meta-analysis revealed a mean depletion of plasma vitamin C concentration of -17.99 µmol/L (39% depletion) (CI = -22.81, -13.17) (trial arms = 25, n = 565, p < 0.001) during the first post-operative week and -18.80 µmol/L (21% depletion) (-25.04, -12.56) (trial arms = 6, n = 166, p < 0.001) 2-3 months post-operatively. Subgroup analyses revealed that these depletions occurred following different types of surgery, however, high heterogeneity was observed amongst trials assessing concentration change during the first post-operative week. Overall, our results warrant larger, long term investigations of changes in post-operative plasma vitamin C concentrations and their potential effects on clinical symptomology.

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Clinical Examination of the Water-Soluble Vitamin Levels in Blood during Peripheral Parenteral Nutrition

Cited by 6 publications

References 15 publications

Need for Thiamine in Peripheral Parenteral Nutrition After Abdominal Surgery in Children

Need for Thiamine in Peripheral Parenteral Nutrition After Abdominal Surgery in Children

Adequacy of vitamin C supplementation in patients with gastrointestinal disorders receiving parenteral nutrition: A randomized trial

The effects of surgery on plasma/serum vitamin C concentrations: a systematic review and meta-analysis

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