Need for Thiamine in Peripheral Parenteral Nutrition After Abdominal Surgery in Children

Masumoto, Kouji; Esumi, Genshiro; Teshiba, Risa; Nagata, Kouji; Nakatsuji, Takanori; Nishimoto, Yuko; Ieiri, Satoshi; Taguchi, Tomoaki

doi:10.1177/0148607108327391

Cited by 7 publications

(7 citation statements)

References 25 publications

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“…In parenterally fed infants and children a deficient thiamine supply may lead to severe lactic acidosis, Wernicke's encephalopathy and even death within a period of days to weeks [105e109]. In children after abdominal surgery, thiamine concentration was below the normal range on postoperative day 3 in the group receiving peripheral parenteral nutrition without thiamine [110]. In preterm infants a parenteral thiamine intake of 780 ug/kg per day led to 10-fold higher serum levels than in cord blood [102].…”

Section: Thiamine (Vitamin B1)mentioning

confidence: 99%

ESPGHAN/ESPEN/ESPR/CSPEN guidelines on pediatric parenteral nutrition: Vitamins

Braegger

Bronský

Cai³

et al. 2018

Clinical Nutrition

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Section: Thiamine (Vitamin B1)mentioning

confidence: 99%

ESPGHAN/ESPEN/ESPR/CSPEN guidelines on pediatric parenteral nutrition: Vitamins

Braegger

Bronský

Cai³

et al. 2018

Clinical Nutrition

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“…These patients can also present signs, such as the classic form of TD, refractory lactic acidosis, myocardial injuries, shock with multiorgan failure, and WE. Most of the time the abnormalities can be resolved with the rapid administration of thiamine supplementation 62–68 C5 : PTD related to high consumption of sugar‐sweetened beverages or isotonic drinks, either in infancy or childhood/adolescence (15%) 22,69–78 .…”

Section: Resultsmentioning

confidence: 99%

Pediatric thiamine deficiency disorders in high‐income countries between 2000 and 2020: a clinical reappraisal

Rakotoambinina

Hiffler²,

Gomes

2021

Annals of the New York Academy of Sciences

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Often thought to be a nutritional issue limited to low-and middle-income countries (LMICs), pediatric thiamine deficiency (PTD) is perceived as being eradicated or anecdotal in high-income countries (HICs). In HICs, classic beriberi cases in breastfed infants by thiamine-deficient mothers living in disadvantaged socioeconomic conditions are thought to be rare. This study aims to assess PTD in HICs in the 21st century. Literature searches were conducted to identify case reports of PTD observed in HICs and published between 2000 and 2020. The analyzed variables were age, country, underlying conditions, clinical manifestations of PTD, and response to thiamine supplementation. One hundred and ten articles were identified, totaling 389 PTD cases that were classified into four age groups: neonates, infants, children, and adolescents. Eleven categories of PTD-predisposing factors were identified, including genetic causes, lifestyle (diabetes, obesity, and excessive consumption of sweetened beverages), eating disorders, cancer, gastrointestinal disorders/surgeries, critical illness, and artificial nutrition. TD-associated hyperlactatemia and Wernicke encephalopathy were the most frequent clinical manifestations. The circumstances surrounding PTD in HICs differ from classic PTD observed in LMICs and this study delineates its mutiple predisposing factors. Further studies are required to estimate its magnitude. Awareness is of utmost importance in clinical practice.

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“…The childhood onset form, Wernicke’s encephalopathy, presents with the triad of ophthalmoplegia, ataxia, and confusion. 29,116–118…”

Section: Vitamin Deficiency Statesmentioning

confidence: 99%

“…Thiamine deficiency occurs in infants who are breastfed by mothers with inadequate intake of thiamine or who receive low-thiamine-content formula, 26,27 and in children who undergo medical or surgical procedures such as gastrointestinal resections, parenteral nutrition, and chemotherapy that result in inadequate thiamine uptake. 29,[116][117][118] The condition in infants is referred to as beriberi, while in children the manifestation falls under the term Wernicke's encephalopathy. 29 Infantile encephalitic beriberi (IEBB) is a rare form of thiamine deficiency complicated by cardiac dysfunction, neck rigidity, and acute peripheral neuritis.…”

Section: Vitamin B1 (Thiamine) Deficiencymentioning

confidence: 99%

“…The childhood onset form, Wernicke's encephalopathy, presents with the triad of ophthalmoplegia, ataxia, and confusion. 29,[116][117][118] The study by Ortigoza-Escobar et al, across 21 centers, reviewed the primary and secondary conditions leading to thiamine deficiency in infants and children. 29 The group identified 79 children with inherited thiamine defects associated with neurological manifestations.…”

Section: Vitamin B1 (Thiamine) Deficiencymentioning

confidence: 99%

See 1 more Smart Citation

Peripheral nerve disease secondary to systemic conditions in children

Wilmshurst

Ouvrier

Ryan

2019

Ther Adv Neurol Disord

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This review is an overview of systemic conditions that can be associated with peripheral nervous system dysfunction. Children may present with neuropathic symptoms for which, unless considered, a causative systemic condition may not be recognized. Similarly, some systemic conditions may be complicated by comorbid peripheral neuropathies, surveillance for which is indicated. The systemic conditions addressed in this review are critical illness polyneuropathy, chronic renal failure, endocrine disorders such as insulin-dependent diabetes mellitus and multiple endocrine neoplasia type 2b, vitamin deficiency states, malignancies and reticuloses, sickle cell disease, neurofibromatosis, connective tissue disorders, bowel dysmotility and enteropathy, and sarcoidosis. In some disorders presymptomatic screening should be undertaken, while in others there is no benefit from early detection of neuropathy. In children with idiopathic peripheral neuropathies, systemic disorders such as celiac disease should be actively excluded. While management is predominantly focused on symptomatic care through pain control and rehabilitation, some neuropathies improve with effective control of the underlying etiology and in a small proportion a more targeted approach is possible. In conclusion, peripheral neuropathies can be associated with a diverse range of medical conditions and unless actively considered may not be recognized and inadequately managed.

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Need for Thiamine in Peripheral Parenteral Nutrition After Abdominal Surgery in Children

Cited by 7 publications

References 25 publications

ESPGHAN/ESPEN/ESPR/CSPEN guidelines on pediatric parenteral nutrition: Vitamins

ESPGHAN/ESPEN/ESPR/CSPEN guidelines on pediatric parenteral nutrition: Vitamins

Pediatric thiamine deficiency disorders in high‐income countries between 2000 and 2020: a clinical reappraisal

Peripheral nerve disease secondary to systemic conditions in children

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