Clinical evidence for an association between left ventricular geometric adaptation and extracardiac target organ damage in essential hypertension

Shigematsu, Yuji; Hamada, Mareomi; Mukai, Mikio; Matsuoka, Hiroshi; Sumimoto, Takumi; Hiwada, Kunio

doi:10.1097/00004872-199501000-00022

Cited by 85 publications

(69 citation statements)

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“…The second issue whether LV geometry is an independent predictor of extracardiac TOD in the general population and in hypertensive individuals has been addressed by several studies investigating vascular changes in subjects with different patterns of LV geometry. 28,29 In a crosssectional study, conducted in a middle-aged general population in northern Italy, Muiesan et al 30 did not observe any involvement in carotid arteries in subjects with concentric remodelling. Only a limited number of studies have been addressed to specifically compare the extent of extracardiac TOD in never-treated essential hypertensive patients with LV concentric remodelling and normal LV geometry.…”

Section: Discussionmentioning

confidence: 96%

Left ventricular concentric remodelling and extracardiac target organ damage in essential hypertension

et al. 2002

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Left ventricular (LV) concentric remodelling is an adaptive change in cardiac geometry frequently observed in arterial hypertension. This study was addressed to investigate the extent of extracardiac target organ damage (TOD) in patients with LV concentric remodelling. Two groups of never-treated essential hypertensives, 31 with normal LV geometry (group I, relative wall thickness: 0.39) and 31 with LV concentric remodelling (group II, relative wall thickness: 0.47) matched for age, sex, body mass index and mean 24-h systolic blood pressure (BP), were included in the study. They underwent clinical and laboratory examination, 24-h ambulatory BP monitoring (ABPM), 24-h urinary collection for microalbuminuria, non-mydriatic photography of ocular fundi, echocardiography and carotid ultrasonography. In both groups age (I: 51 ؎ 11 years; II: 51 ؎ 11

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Section: Discussionmentioning

confidence: 96%

Left ventricular concentric remodelling and extracardiac target organ damage in essential hypertension

et al. 2002

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“…29,30 This occurs in both HT and NT subjects with age. 31 Left ventricular mass has been found to increase with age independently of blood pressure.…”

Section: Discussionmentioning

confidence: 99%

Hypertensive Target-Organ Damage in the Very Elderly

et al. 2003

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Abstract-In people aged Ͼ80 years, the so-called very elderly, there is uncertainty about the relation between hypertension and cardiovascular morbidity. The aims of this study were to investigate whether hypertension in people aged Ͼ80 years is associated with target-organ damage, over and above the effects of age, and to determine whether ambulatory blood pressure monitoring (ABPM) could improve on conventional blood pressure monitoring (CBPM) in predicting target-organ damage. Investigations included echocardiographic measurement of left ventricular mass index (LVMI), brain magnetic resonance imaging assessment of periventricular hyperintensity (PVH), urinary albumin-creatinine ratio (ACR), aortic pulse wave velocity (PWV), and 24-hour ABPM. Forty-three subjects, at a mean age 84.3 years, were studied, 22 normotensive (NT) and 21 hypertensive (HT). CBP was 184/89 and 145/76 mm Hg in the HT and NT groups, respectively. In men, LVMI was significantly greater in HT subjects, 157Ϯ37 vs 123Ϯ15 g/m 2 in NT subjects (PϽ0.05). In women, LVMI was similar in both groups. Urinary ACR was greater in HT than in NT subjects (log ACR, 1.21Ϯ0.50 vs 0.95Ϯ0.23; PϽ0.05). Cerebral PVH grade was higher in the HT subjects (2.6Ϯ0.8 vs 2.2Ϯ0.9), although this difference was not significant. Aortic PWV did not differ between the 2 groups. ABPM was positively associated with urinary ACR and cerebral PVH, independent of its correlation with CBPM. In advanced old age, HT is associated with evidence of target-organ damage. ABPM can improve on CBPM in predicting very elderly subjects with HT target-organ damage.

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“…Several studies have reported a relation between cardiac damage and renal damage in hypertensive patients. Echocardiographically determined LV mass and geometry have been associated with serum creatinine in patients with essential hypertension (19,20). LV mass has also been related to proteinuria and microalbuminuria in such patients (5,21,22).…”

Section: Discussionmentioning

confidence: 99%

Association between Left Ventricular Diastolic Dysfunction and Renal Hemodynamic Change in Patients with Treated Essential Hypertension

et al. 2003

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The heart and kidneys are important target organs in hypertension. Early signs of hypertensive target organ Abnormalities in left ventricular (LV) diastolic filling have been described in patients with hypertension, even in the absence of left ventricular hypertrophy (7-9). Moreover, impaired LV diastolic relaxation is a prognostic indicator of cardiovascular risk (10). An increased intrarenal resistance index (RI) evaluated by renal Doppler ultrasonography has also been reported in patients with essential hypertension (11,12). Assessment of intrarenal vascular resistance is useful in determining the degree of intrarenal damage. High levels of RI are associated with subclinical end-organ damage-namely microalbuminuria, LV hypertrophy, and carotid atherosclerosis-in hypertensive patients (13,14). In addition, an RI value of ≥ 0.8 is a strong and independent

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Clinical evidence for an association between left ventricular geometric adaptation and extracardiac target organ damage in essential hypertension

Cited by 85 publications

References 0 publications

Left ventricular concentric remodelling and extracardiac target organ damage in essential hypertension

Left ventricular concentric remodelling and extracardiac target organ damage in essential hypertension

Hypertensive Target-Organ Damage in the Very Elderly

Association between Left Ventricular Diastolic Dysfunction and Renal Hemodynamic Change in Patients with Treated Essential Hypertension

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