Clinical Evaluation of Zinc Therapy in Rheumatoid Arthritis

Al-Hashimi, Ali H.; Al-Edani, Nabil I.; Al-Ali, Hadeal S.

doi:10.33762/mjbu.2007.48249

Cited by 3 publications

(1 citation statement)

References 17 publications

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“…moreover, zinc-containing proteins accumulate in the liver and inflamed joints, reducing plasma zinc levels in patients [14]. Patients supplemented with zinc showed improved laboratory and clinical parameters for R.A. [15]. zinc has a bone-forming effect and reduces osteoclast activity [16].…”

Section: Introductionmentioning

confidence: 99%

Some Trace Elements and Oxidative Stress Status in Patients with Chronic Rheumatoid Arthritis

Alameer¹,

Alammar²

2023

JBB

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Background Rheumatoid arthritis (R.A.) is a complex polygenic, autoimmune inflammatory disease. It was disturbing that almost 1-2% of people depended on that geographic spreading worldwide. R.A. can result from the interaction of genetic, environmental, and autoimmunity. It is characterized by non-organ-specific self-reactive antibody production and chronic synovitis leading to the damage of cartilage and bone.Objectives To evaluate the sera of trace elements and oxidative stress levels in patients detected with chronic rheumatoid arthritis. Determination of some trace elements such as copper, zinc, and iron in the sera of patients. Patients and MethodA case-control study was done on the Iraqi population from Al-Najaf, an Iraqi city. Blood samples were collected from 135 volunteers from September 2021 to February 2022 from Al-Sadder Medical City (Al-Najaf). The 180 volunteers in our study were divided into two groups patient group consisting of 90 individuals ages range: (20-70 years), male and female, and a control group consisting of 45 individuals. Blood was drawn from the patients to measure the copper, zinc, and iron concentration level using the Colorimetric method technique. ResultsThe average zinc concentration was lower in the patient's group than in the reference category. The average copper concentration was more significant in the patient's group than in the reference category. In addition, the average Zn/Cu ratio was lower in the patient's group compared to the reference category. There was no statistical variation in average serum iron between patients and the reference category. However, the average Zn/Fe ratio was lower in the patient's group compared to the reference category control group. ConclusionLower levels of zinc and a higher level of copper suggest a role for those trace elements on that pathogen of R.A.

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Section: Introductionmentioning

confidence: 99%

Some Trace Elements and Oxidative Stress Status in Patients with Chronic Rheumatoid Arthritis

Alameer¹,

Alammar²

2023

JBB

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Disease-Modifying Antirheumatic Diets: The New Treatment Modalities for Rheumatoid Arthritis

2018

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Autoimmune responses need to be identified and managed promptly to avoid deleterious consequences. Autoimmune diseases, such as rheumatoid arthritis (RA), are debilitating and can lead to a compromised quality of life for patients. Autoimmune disease severity is directly related to sex (females are more prone to the diseases), as well as age, the environment, and genetic factors. Though many of these triggers cannot be avoided, disease onset and progression can be delayed, managed, and to some extent avoided altogether by dietary interventions. Certain food and dietary components have been observed to have anti-inflammatory properties and can thus be included in a patient’s diet to reduce disease symptoms. This review will assess dietary components with regard to RA, including those that are frequently observed to be different in patients with RA in comparison to healthy individuals. The authors conclude that assessment of the nutritional status of a patient, including the deficiency of vitamins or other nutrients and energy requirements, should be recorded and a dietary regimen should be designed accordingly for a better therapeutic response.

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Subjective Symptoms and Disease Activity Related to Serum Zinc Concentration in Primary Sjögren’s Syndrome

Akiya,

Nishihara,

Nagasawa

et al. 2024

JCM

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Background/Objectives: We examined the frequency of zinc deficiency in patients with Sjögren’s syndrome (SS) and the relationship between zinc deficiency and each of the subjective symptoms and disease activity. Methods: We enrolled 164 patients aged ≥ 20 years with primary SS (pSS) based on the revised diagnostic criteria of the Ministry of Health, Labor and Welfare (1999) and 144 patients with RA diagnosed according to the ACR/EULAR classification criteria for RA (2010) as a comparison group. Subjective symptoms were confirmed using an original questionnaire, and disease activity was determined using the European League Against Rheumatism Sjögren’s Syndrome Disease Activity Index (ESSDAI). The serum zinc concentrations were measured in both SS and RA patients. Results: The rate of zinc deficiency in the SS group was 26.1%, significantly higher than that in the RA group (7.6%). The rate of zinc deficiency was significantly higher in the pSS group compared with Japanese health checkup recipients reported in the literature. The mean serum zinc concentration in primary SS was 60.6 ± 7.3 µmol/L in the high disease activity group with an ESSDAI of ≥5 points, which was significantly lower than the concentration of 69.7 ± 10.2 µmol/L in patients with an ESSDAI of ≤4 points. Conclusions: The frequency of zinc deficiency was higher in patients with pSS than in patients with RA. Disease activity was also higher in patients with zinc deficiency, suggesting an association between zinc concentration and organ involvement in pSS.

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Clinical Evaluation of Zinc Therapy in Rheumatoid Arthritis

Cited by 3 publications

References 17 publications

Some Trace Elements and Oxidative Stress Status in Patients with Chronic Rheumatoid Arthritis

Some Trace Elements and Oxidative Stress Status in Patients with Chronic Rheumatoid Arthritis

Disease-Modifying Antirheumatic Diets: The New Treatment Modalities for Rheumatoid Arthritis

Subjective Symptoms and Disease Activity Related to Serum Zinc Concentration in Primary Sjögren’s Syndrome

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