Clinical evaluation of unselected cardiac arrest survivors in a tertiary center over a 1-year period (the LAZARUZ study)

Marstrand, Peter; Corell, Pernille; Henriksen, Finn Lund; Pehrson, Steen; Bundgaard, Henning; Theilade, Juliane

doi:10.1016/j.jelectrocard.2016.05.008

Cited by 6 publications

(5 citation statements)

References 32 publications

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“…In the investigation of an SCA survivor, detailed personal and three‐generation family history should be taken with the assistance of a multidisciplinary team, including witness accounts. 77 1 B‐NR 2. All possible details surrounding an SCA event should be sought, including patient's recollection, witness accounts, and medical records. 216–220 …”

Section: Investigation Of Sudden Cardiac Arrest Survivorsmentioning

confidence: 99%

“…A detailed history is a crucial component of diagnosing the cause of SCA. Studies utilizing a comprehensive, systematic approach including history, physical examination, ECGs (eg, 12‐lead ECG, treadmill, 24‐hour Holter, signal‐averaged ECG, if needed), cardiac imaging (eg, coronary angiography, echocardiogram, CMR, CT), provocative testing, electrophysiological study, cardiac biopsy, and genetic testing have shown that a diagnosis can be established in a substantial proportion of survivors of SCA 216–219 …”

Section: Investigation Of Sudden Cardiac Arrest Survivorsmentioning

confidence: 99%

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2020 APHRS/HRS expert consensus statement on the investigation of decedents with sudden unexplained death and patients with sudden cardiac arrest, and of their families

Stiles

Wilde

Abrams

et al. 2021

Journal of Arrhythmia

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This international multidisciplinary document intends to provide clinicians with evidence‐based practical patient‐centered recommendations for evaluating patients and decedents with (aborted) sudden cardiac arrest and their families. The document includes a framework for the investigation of the family allowing steps to be taken, should an inherited condition be found, to minimize further events in affected relatives. Integral to the process is counseling of the patients and families, not only because of the emotionally charged subject, but because finding (or not finding) the cause of the arrest may influence management of family members. The formation of multidisciplinary teams is essential to provide a complete service to the patients and their families, and the varied expertise of the writing committee was formulated to reflect this need. The document sections were divided up and drafted by the writing committee members according to their expertise. The recommendations represent the consensus opinion of the entire writing committee, graded by Class of Recommendation and Level of Evidence. The recommendations were opened for public comment and reviewed by the relevant scientific and clinical document committees of the Asia Pacific Heart Rhythm Society (APHRS) and the Heart Rhythm Society (HRS); the document underwent external review and endorsement by the partner and collaborating societies. While the recommendations are for optimal care, it is recognized that not all resources will be available to all clinicians. Nevertheless, this document articulates the evaluation that the clinician should aspire to provide for patients with sudden cardiac arrest, decedents with sudden unexplained death, and their families.

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Section: Investigation Of Sudden Cardiac Arrest Survivorsmentioning

confidence: 99%

Section: Investigation Of Sudden Cardiac Arrest Survivorsmentioning

confidence: 99%

2020 APHRS/HRS expert consensus statement on the investigation of decedents with sudden unexplained death and patients with sudden cardiac arrest, and of their families

Stiles

Wilde

Abrams

et al. 2021

Journal of Arrhythmia

View full text Add to dashboard Cite

show abstract

“…A detailed history is a crucial component of diagnosing the cause of SCA. Studies utilizing a comprehensive, systematic approach including history, physical examination, ECGs (eg, 12-lead ECG, treadmill, 24-hour Holter, signal-averaged ECG, if needed), cardiac imaging (eg, coronary angiography, echocardiogram, CMR, CT), provocative testing, electrophysiological study, cardiac biopsy, and genetic testing have shown that a diagnosis can be established in a substantial proportion of survivors of SCA [216][217][218][219].…”

mentioning

confidence: 99%

2020 APHRS/HRS expert consensus statement on the investigation of decedents with sudden unexplained death and patients with sudden cardiac arrest, and of their families

et al. 2021

View full text Add to dashboard Cite

This international multidisciplinary document intends to provide clinicians with evidence-based practical patient-centered recommendations for evaluating patients and decedents with (aborted) sudden cardiac arrest and their families. The document includes a framework for the investigation of the family allowing steps to be taken, should an inherited condition be found, to minimize further events in affected relatives. Integral to the process is counseling of the patients and families, not only because of the emotionally charged subject, but because finding (or not finding) the cause of the arrest may influence management of family members. The formation of multidisciplinary teams is essential to provide a complete service to the patients and their families, and the varied expertise of the writing committee was formulated to reflect this need. The document sections were Developed in partnership with and endorsed by the Asia Pacific Heart Rhythm Society (APHRS) and the Heart Rhythm Society (HRS). Developed in collaboration with and endorsed by the Association for European Cardiovascular Pathology (AECVP), the European Society of Human Genetics (ESHG), the Latin American Heart Rhythm Society (LAHRS), the National Society of Genetic Counselors (NSGC), and the Pediatric and Congenital Electrophysiology Society (PACES). Developed in collaboration with the European Heart Rhythm Association (EHRA). For copies of this document, please contact the Elsevier Inc. Reprint Department

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“…Additionally, Mavrogeni et al, reported that CMR can be of great value in evaluation of arrhythmogenesis in sudden cardiac death of healthy athletes especially by its ability to differentiate non-ischemic cardiomyopathy with athlete's heart [10]. However, another study with 36 cardiac arrest survivors found only minor findings in CMR imaging and other study that evaluated the cause in 43 cardiac arrest survivors reported that >50% of the patients who underwent CMR imaging had normal or non-diagnostic findings [4]. Considering the conflicting results of CMR imaging in the cardiac arrest survivors, the usefulness of CMR imaging is still uncertain.…”

Section: Discussionmentioning

confidence: 99%

“…However, the cause of OHCA can remain uncertain even after echocardiography and coronary angiography. A previous study reported that approximately 40% of cases remain without an overt diagnosis despite vigorous efforts to elucidate the causes of cardiac arrest [4]. It is still difficult to elucidate the etiology of cardiac arrest without significant coronary artery lesion for physicians.…”

Section: Introductionmentioning

confidence: 99%

Cardiac Magnetic Resonance Imaging for Nonischemic Cardiac Disease in Out-of-Hospital Cardiac Arrest Survivors Treated with Targeted Temperature Management: A Multicenter Retrospective Analysis

Kim

Youn

Lee

et al. 2021

JCM

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(1) Background: Cardiac magnetic resonance (CMR) imaging is an emerging tool for investigating nonischemic cardiomyopathies and cardiac systemic disease. However, data on the cardiac arrest population are limited. This study aimed to evaluate the usefulness of CMR imaging in out-of-hospital cardiac arrest (OHCA) survivors treated with targeted temperature management (TTM). (2) Methods: We conducted the retrospective observational study using a multicenter registry of adult non-traumatic comatose OHCA survivors who underwent TTM between January 2010 and December 2019. Of the 949 patients, 389 with OHCA of non-cardiac cause, 145 with significant lesions in the coronary artery, 151 who died during TTM, 81 without further evaluation due to anticipated poor neurological outcome, and 51 whose etiology is underlying disease were excluded. In 36 of the 132 remaining patients, the etiologies included variant angina, long QT syndrome, and complete atrioventricular block in ancillary studies. Fifty-six patients were diagnosed idiopathic ventricular fibrillation without CMR. (3) Results: CMR imaging was performed in the remaining 40 patients with cardiac arrest of unknown cause. The median time from cardiac arrest to CMR imaging was 10.1 days. The CMR finding was normal in 23 patients, non-diagnostic in 12, and abnormal in 5, which suggested non-ischemic cardiomyopathy but did not support the final diagnosis. (4) Conclusions: CMR imaging may not be useful for identifying unknown causes of cardiac arrest in OHCA survivors treated with targeted temperature management without definitive diagnosis even after coronary angiography, echocardiography, and electrophysiology studies. However, further large-scale studies will be needed to confirm these findings.

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Clinical evaluation of unselected cardiac arrest survivors in a tertiary center over a 1-year period (the LAZARUZ study)

Cited by 6 publications

References 32 publications

2020 APHRS/HRS expert consensus statement on the investigation of decedents with sudden unexplained death and patients with sudden cardiac arrest, and of their families

2020 APHRS/HRS expert consensus statement on the investigation of decedents with sudden unexplained death and patients with sudden cardiac arrest, and of their families

2020 APHRS/HRS expert consensus statement on the investigation of decedents with sudden unexplained death and patients with sudden cardiac arrest, and of their families

Cardiac Magnetic Resonance Imaging for Nonischemic Cardiac Disease in Out-of-Hospital Cardiac Arrest Survivors Treated with Targeted Temperature Management: A Multicenter Retrospective Analysis

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