Clinical evaluation of total and lipid bound sialic acid levels in oral precancer and oral cancer

Taqi, Syed Ahmed

doi:10.4103/0971-5851.96967

Cited by 10 publications

(15 citation statements)

References 15 publications

(38 reference statements)

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“…3,23 Taqi et al in their study have mentioned that fall in serum sialic acid level occurs in postoperative patients who respond well to the treatment and rise in sialic acid level may occur in non responders. 23 Trivedi et al also reported significantly lower level of free and protein bound sialic acid in saliva fifteen days after the radiotherapy compared to the value observed before radiotherapy. 3 This signifies that sialic acid level is directly related to the tumor burden and it could be used as adjunctive diagnostic marker in oral cancer.…”

Section: Discussionmentioning

confidence: 98%

Estimation of Serum and Salivary Sialic Acid Level in Patients with Oral Squamous Cell Carcinoma

Poudel

Bajracharya

Bhattacharyya

et al. 2019

J Coll Med Sci-Nepal

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Background: Sialic acid is a glycoprotein that is considered as an important constituent of cell membrane. Altered glycosylation is one of the important molecular changes that accompany malignant transformation. Several studies in past have shown that changes in serum and salivary sialic acid levels in cancer patients correlate well with tumor burden. Some of the findings suggested that sialic acid levels could be elevated in cancer patients before the occurrence of clinical symptoms. The purpose of this study is to estimate serum and salivary sialic acid level in oral squamous cell carcinoma patients and correlate their level with the histopathological grading of oral squamous cell carcinoma. Methods: Blood and saliva samples were collected from 50 patients with oral squamous cell carcinoma and 50 healthy subjects. Serum and salivary sialic acid levels in both free and protein bound forms were measured spectrophotometrically. This was correlated with histopathological grades of oral squamous cell carcinoma. The statistical analysis was done using SPSS software. Results: A statistically significant rise in serum and salivary sialic acid level was noted in OSCC subjects compared to the controls. Furthermore, significant difference in both serum and salivary sialic acid level was noted between well and poorly differentiated OSCC. Conclusions: Our report suggests that sialic acid is a valuable biomarker of oral squamous cell carcinoma. It may be used to assess the histological grading of oral cancer and predict the disease outcome and response to the therapy.

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Section: Discussionmentioning

confidence: 98%

Estimation of Serum and Salivary Sialic Acid Level in Patients with Oral Squamous Cell Carcinoma

Poudel

Bajracharya

Bhattacharyya

et al. 2019

J Coll Med Sci-Nepal

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“…Sialic acids are also important terminal sugars in cell membrane glycoproteins and glycolipids (31). Previous studies have showed elevated levels of serum and salivary sialic acid in various carcinomas, including oral pre-cancer and OC (32)(33)(34)(35)(36)(37). Unfortunately, sialic acid was not among these 19 metabolites that we managed to identify and quantify in the present study.…”

Section: Discussionmentioning

confidence: 99%

Potential role of nuclear magnetic resonance spectroscopy to identify salivary metabolite alterations in patients with head and neck cancer

et al. 2018

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The analysis of the salivary metabolomic profile may offer an early phase approach to assess the changes associated with a wide range of diseases including head and neck cancer. The aim of the present study was to investigate the potential of nuclear magnetic resonance (NMR) spectroscopy for detecting the salivary metabolic changes associated with head and neck squamous cell carcinoma (HNSCC). Unstimulated whole-mouth saliva samples collected from HNSCC patients (primary tumour was located either in the larynx or in the oral cavity) and healthy controls were analysed by 1 H-NMR spectroscopy. Reliably identified salivary metabolites were quantified and the determined concentration values were compared group-wise using a Mann-Whitney U-test. Multivariate discrimination function analysis (DFA) was conducted to identify such a combination of metabolites, when considered together, that gives maximum discrimination between the groups. HNSCC patients exhibited significantly increased concentrations of 1,2-propanediol (P=0.032) and fucose (P=0.003), while proline levels were significantly decreased (P=0.043). In the DFA model, the most powerful discrimination was achieved when fucose, glycine, methanol and proline were considered as combined biomarkers, resulting in a correct classification rate of 92.1%, sensitivity of 87.5% and specificity of 93.3%. To conclude, NMR spectrometric analysis was revealed to be a feasible approach to study the metabolome of saliva that is sensitive to metabolic changes in HNSCC and straightforward to collect in a non-invasive manner. Salivary fucose was of particular interest and therefore, controlled longitudinal studies are required to assess its clinical relevance as a diagnostic biomarker in HNSCC.

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“…It could be used as an adjunct to diagnosis, monitor response to therapy and assess the staging of cancer. [ 25 ] The focus on young adult population has to be established to accomplish the objective of tumor down staging. Consequently, at the time of diagnosis, patients are twice as likely to have an advanced tumor compared to a localized lesion.…”

Section: Discussionmentioning

confidence: 99%

Low resource screening method of pre-cancerous lesions and its reversal by Triphala in teen-age Indian population

Deshpande

Tandon

Deshpande

2014

AYU

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Background:Cancer screening is the main weapon for early detection at a pre-invasive or premalignant stage. It has been reported that over 12 million people use some form of tobacco, which is one of the high risk factors and has hence become an alarming world-wide problem.Aim:To evaluate the effective diagnostic screening of disease in its early stage by inexpensive method and also to evaluate the effect of indigenous mouthrinse on reversal of pre-cancerous lesions.Materials and Methods:The screening for teenagers belonging to low socio-economic status was carried out. Suspected subjects were evaluated for the reversal of the lesions by use of Ayurvedic preparation as a mouthwash. From 13 to19 years working-child population of North India was selected for the study. Screening was performed by new method-visual inspection with acetic acid. The positive subjects were further investigated by pap smear and biopsy was done as a confirmatory histopathological report. In second phase, the subjects showing positive lesions were advised indigenous anti-cancer mouth rinse and its effect was evaluated after 6 month and 9 month of prescribing the rinse.Results:The total 1095 children were screened (831 boys and 264 girls). Out of total 34 teenager boys were diagnosed, as acetowhite positive lesion. All the acetowhite positive lesions were found exclusively in males. Histological findings after 9 month use of Triphala mouth rinse revealed no changes in cells in 23 (85.2%), hyperkeratinization in 2 (7.4%), hyperkeratinization and spongiosis was evident in 1 (3.7%), mild pleomorphism in 1 (3.7%) patient. Comparative evaluation from 0-9 month showed statistically highly significant test (P < 0.01).Conclusion:Use of different forms of tobacco and betel nut showed convincing relationship between developments of oral pre-cancerous lesions. Triphala was found to have great potential for reversal of these lesions.

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Clinical evaluation of total and lipid bound sialic acid levels in oral precancer and oral cancer

Cited by 10 publications

References 15 publications

Estimation of Serum and Salivary Sialic Acid Level in Patients with Oral Squamous Cell Carcinoma

Estimation of Serum and Salivary Sialic Acid Level in Patients with Oral Squamous Cell Carcinoma

Potential role of nuclear magnetic resonance spectroscopy to identify salivary metabolite alterations in patients with head and neck cancer

Low resource screening method of pre-cancerous lesions and its reversal by Triphala in teen-age Indian population

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