Clinical evaluation of topical isotretinoin in the treatment of actinic keratoses

Alirezai, M.; Dupuy, P; Amblard, P; Kalis, B; Souteyrand, P.; Frappaz, A.; Sendagorta, E.

doi:10.1016/s0190-9622(94)70054-0

Cited by 60 publications

(22 citation statements)

References 11 publications

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“…There are a number of studies which evaluated the effectiveness of topical retinoids in the prevention and treatment of NMSCs, primarily AK [91,92,93,94,95,96,97,98,99,100,101]. The advantage of using topical retinoids is systemic toxicity avoidance, although there may be local adverse effects such as erythema, scaling, burning, and irritation which vary with the drug concentration.…”

Section: Classical Therapy Of Nmscsmentioning

confidence: 99%

Neoplastic Multifocal Skin Lesions: Biology, Etiology, and Targeted Therapies for Nonmelanoma Skin Cancers

Fernandes

Santos²,

Kovačević³

et al. 2017

Skin Pharmacol Physiol

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Neoplastic skin lesions are multifocal, diffuse skin infiltrations of particular relevance in the differential diagnosis of ulcerative, nodular, or crusting skin lesions. Nonmelanoma skin cancers (NMSCs), namely, basal cell carcinoma (BCC), squamous cell carcinoma (SCC), and also actinic keratosis (AK), are the most common malignant tumors in humans. BCCs do not proliferate rapidly and most of the times do not metastasize, while SCCs are more infiltrative, metastatic, and destructive. AKs are precursor lesions of cutaneous SCCs. The classical therapy of NMSCs makes use of photodynamic therapy associated with chemotherapeutics. With improved understanding of the pathological mechanisms of tumor initiation, progression, and differentiation, a case is made towards the use of targeted chemotherapy with the intent to reduce the cytotoxicity of classical treatments. The present review aims to describe the current state of the art on the knowledge of NMSC, including its risks factors, oncogenes, and skin carcinogenesis, discussing the classical therapy against new therapeutic options.

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Section: Classical Therapy Of Nmscsmentioning

confidence: 99%

Neoplastic Multifocal Skin Lesions: Biology, Etiology, and Targeted Therapies for Nonmelanoma Skin Cancers

Fernandes

Santos²,

Kovačević³

et al. 2017

Skin Pharmacol Physiol

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“…Effects on gene 670 expression are also possible by inhibition of specific transcription 671 factors (Michel et al, 1998). First generation retinoids evaluated 672 for topical treatment of AK include tretinoin (all trans-retinoic 673 acid) and isotretinoin (13-cis-retinoic acid); the third generation 674 retinoid, adapalene, has also been investigated (Kligman and 675 Thorne, 1991;Alirezai et al, 1994;Kang et al, 2003). Tretinoin 676 and adapalene have also been used to treat AK or NMSC in conjunc-677 tion with laser ablation therapy (Bercovitch, 1987;Kang et al, 678 2003; Prens et al, 2013;Pearce and Williford, 2014).…”

Section: -Flurouracilmentioning

confidence: 99%

Topical therapies for skin cancer and actinic keratosis

Haque

Rahman

Thurston

et al. 2015

European Journal of Pharmaceutical Sciences

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The global incidence of skin cancer and actinic keratosis (AK) has increased dramatically in recent years. Although many tumours are treated with surgery or radiotherapy topical therapy has a place in the management of certain superficial skin neoplasms and AK. This review considers skin physiology, non-melanoma skin cancer (NMSC), the relationship between AK and skin cancer and drugs administered topically for these conditions. The dermal preparations for management of NMSC and AK are discussed in detail. Notably few studies have examined drug disposition in cancerous skin or in AK. Finally, recent novel approaches for targeting of drugs to skin neoplasms and AK are discussed.

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“…At nonphysiologic concentrations, RA inhibits the proliferation of human fibroblasts and synthesis of collagen type III and I and affects wound healing [18][19][20][21].…”

Section: Effects On Intercellular Matrix Componentsmentioning

confidence: 99%

“…Isotretinoin 0.1% cream cannot compete with more rapid treatments of actinic keratoses. However, its effect on facial lesions may be beneficial during long-term treatment of associated sun-damaged skin [127,128].…”

Section: Actinic Keratosismentioning

confidence: 99%