Clinical evaluation of topical application of perio-Q gel (Coenzyme Q ₁₀) in chronic periodontitis patients

Abstract

Background and Objectives:Coenzyme Q10 is a well studied antioxidant in medical literature, but studies regarding its efficacy in periodontal diseases are few. Hence, the aim of this study was to test the efficacy of coenzyme Q10 in the form of gel (Perio-Q) in patients with chronic gingivitis and periodontitis.Materials and Methods:A total of 12 patients were enrolled. A split mouth design was used for topical (extrasulcular) application, intra-pocket application alone, intra-pocket application combined with scaling and root planing (SRP) and SRP only in each quadrant, respectively. Clinical parameters such as plaque index, gingival index, gingival bleeding index, probing pocket depth, clinical attachment level were assessed at baseline, 3rd week, and 6th week. The results were subjected to statistical analysis, which were expressed as mean±SD and proportions as percentages. Intra group comparisons were made by paired t-test and one way analysis of variance (ANOVA) for inter-group comparisons. Categorical data was analyzed by Fisher's exact test.Results:The results showed on intra-group analysis significant reduction (P<0.01) of clinical parameters (plaque index (PI), gingival index (GI), gingival bleeding index (GBI), periodontal probing pocket depth (PPD), and clinical attachment level (CAL)) in all four treatment groups, whereas on inter-group analysis, intra-pocket gel application in combination with SRP showed significant reduction (P<0.05) for PI, GI, GBI, and CAL in comparison to intra-pocket gel alone.Interpretation and Conclusion:In the present study, in chronic periodontitis patients, sub-gingival mechanical debridement only and with Perio-Q gel showed almost similar clinical results without any statistically significant differences. Hence, it confirmed the primary role of basic mechanical approaches in periodontal therapy and did not provide enough clinical support for the superiority of adjunctive use of Perio-Q gel. However, it appears that Perio-Q gel in this study may have a potential additive effect. Further, long term clinical studies of Perio-Q gel with various doses and duration need to be conducted.

A comparative evaluation of topical and intrasulcular application of coenzyme Q10 (Perio QTM) gel in chronic periodontitis patients: A clinical study

“…Our study has shown decreases in the clinical parameters scores, which are consistent with the earlier studies performed by Hans et al .,[3] Wilkinson et al . [15] and Chatterjee et al .…”

Comparative evaluation of coenzyme Q10-based gel and 0.8% hyaluronic acid gel in treatment of chronic periodontitis

“…[6] Similar findings were observed in hyaluronic acid group and were in accordance with the study done by Xu et al . [16] and Gontiya and Galgali.…”

Plastoquinone and Ubiquinone in Plants: Biosynthesis, Physiological Function and Metabolic Engineering

“…Its positive role in the treatment of male infertility also relies on the antioxidant properties and bioenergetics (Balercia et al, 2004; Mancini et al, 2005; Balercia et al, 2009; Mancini and Balercia, 2011; Safarinejad, 2012). As a good immunomdulator, UQ 10 has been used to treat chronic gingivitis and periodontitis (Chatterjee et al, 2012; Hans et al, 2012). A series of toothpaste containing UQ 10 are developed and sold in the market.…”