A comparative evaluation of topical and intrasulcular application of coenzyme Q10 (Perio Q ^TM ) gel in chronic periodontitis patients: A clinical study

Abstract

Background and Objectives:Coenzyme Q10 is a well-studied antioxidant in the medical literature, but studies regarding its efficacy in periodontal diseases are few. coenzymeoenzyme Q10 serves as an endogenous antioxidant and its increased concentration in the diseased gingiva effectively suppresses advanced periodontal inflammation. The aim of this study is to evaluate the efficacy of coenzyme Q10 (Perio Q™) as an adjunct to scaling and root planing in patients with chronic periodontitis.Materials and Methods:A total of 18 patients were enrolled for the study. The selected subjects were treated in three different quadrants randomly. The control quadrant was treated by scaling and root planing only, while the other two test quadrants were treated by intra-pocket application of gel combined with scaling or root planing and topical applications combined with scaling and root planning, respectively. Clinical parameters such as plaque index, gingival index, gingival bleeding index and probing pocket depth were assessed at baseline and at the 2nd week and 4th weeks. The results were subjected to statistical analysis.Results:There was a significant improvement in all clinical parameters in the test sites seen at the end of the 4-week period. Sites with bleeding on probing were reduced more in the test group than in the control group.Conclusion:Coenzyme Q10 can be said to have a beneficial effect on periodontitis when used as an adjunct to scaling and root planing.

Placement of Sticky Bone™ in Patients with Generalized Periodontitis Previously Treated with Coenzyme Q10

“…In an experimental study by Sanadi,7 CoQ10 was used in patients of aggressive periodontitis, and the author reported that there was no significant difference in the debris index score, calculus index score, bleeding index score, and reduction in gingival inflammation between the experimental and control sites; however, the gel was not injected in the pocket, but the patients were asked to brush and massage the gums with it. In rest of the following studies, it was injected in the pocket; however, these studies show a short follow-up, such as Pitale et al 8 showed 2-week follow-up in gingivitis and mild periodontitis, Sale et al 9 for 4 weeks, Raut-Sethi 10 for a period of 1 month, and Roopa et al for 2 months. 11 Early studies conducted by Wilkinson et al 12,13 and Hanioka et al 14 stated significant improvement in pocket depth, and in these studies also patients were followed up for 3 and 6 weeks, respectively.…”

“…Also, bleeding from the gingival sulcus is the first sign of start of the disease; 17 thus, when it has advanced to periodontitis, bleeding on probing does not play a key role in the diagnosis of the disease and course of treatment which follows. Various studies [7][8][9][10][11][12][13][14][15][16] have reported that CoQ10 reduces periodontitis and has an adjunct effect on the pocket after SRP; however, these studies have a short follow-up period which is not sufficient to comment on the periodontal status of a patient with periodontitis. In the present study, it was observed that patients with a pocket of 5-7 mm who were treated with local delivery of CoQ10 after SRP showed beneficial effects for initial 3 months only, and at 6 months the pocket depth started to return to its previous levels.…”

Non-Nutrient, Naturally Occurring Phenolic Compounds with Antioxidant Activity for the Prevention and Treatment of Periodontal Diseases

“…Topical application is a convenient method in the dental clinical setting, and clinical trials evaluating benefits of CoQ topical ( i.e. , extrasulcular) application (in gel-form) also exist in humans [ 38 , 51 , 52 ]. Moreover, intra-pocket application was tested as well in the same trials [ 38 , 51 ].…”

“…, extrasulcular) application (in gel-form) also exist in humans [ 38 , 51 , 52 ]. Moreover, intra-pocket application was tested as well in the same trials [ 38 , 51 ]. These studies showed that both types of application of a gel containing CoQ 10 for 6 weeks improved major clinical parameters.…”

“…These studies showed that both types of application of a gel containing CoQ 10 for 6 weeks improved major clinical parameters. Further, CoQ 10 use has also been tested after a scaling and root planning treatment [ 38 , 51 ], and its application combined with mechanical treatment offered better results, but only when the gel was applied to the periodontal pockets [ 38 ].…”