Clinical evaluation of the efficacy of EDTA solution as an endodontic irrigant

Detection and Eradication of Microorganisms in Root-filled Teeth Associated With Periradicular Lesions: An In Vivo Study

“…In addition to its cleaning ability, EDTA may detach biofilms adhering to root canal walls (17). This may explain why an EDTA irrigant proved to be highly superior to saline in reducing intracanal microbiotica (19), despite the fact that its antiseptic capacity is relatively limited (17,34). The antibacterial activity of NaOCl has been proved in previous studies.…”

Root Canal Irrigants

“…In addition to their cleaning ability, chelators may detach biofilms adhering to root canal walls (Kishor Gulabivala, personal communication). This may explain why an EDTA irrigant proved to be highly superior to saline in reducing intracanal microbiota (133), despite the fact that its antiseptic capacity is relatively limited (134). Albeit never shown in a randomized clinical trial, an alternating irrigating regimen of NaOCl and EDTA may be more efficient in reducing bacterial loads in root canal systems than NaOCl alone (100).…”

How Useful Is Root Canal Culturing in Predicting Treatment Outcome?

“…It was previously demonstrated that bacteria can regrow in empty canals. Thirty-six of 150 canals (24%) (49) and four of 12 canals (33%) (31) showed a negative culture at the first visit but were positive at the second visit 7 days later when canals were left empty. On the contrary, bacteria also appear to die off in empty canals.…”