How Useful Is Root Canal Culturing in Predicting Treatment Outcome?

Sathorn, Chankhrit; Parashos, Peter; Messer, Harold H.

doi:10.1016/j.joen.2006.11.006

Cited by 102 publications

(98 citation statements)

References 53 publications

(86 reference statements)

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“…Bacteria can pass unnoticed by the paper point sampling approach (39). The sampling collection method using paper points might not able to obtain samples that can really represent the bacterial population of the root canal system of infected teeth, which is crucial for the improvement of the treatment protocols (40)(41)(42)(43)(44).…”

Section: Discussionmentioning

confidence: 99%

The Effect of Sodium Hypochlorite and Chlorhexidine as Irrigant Solutions for Root Canal Disinfection: A Systematic Review of Clinical Trials

Gonçalves

Rodrigues

Andrade

et al. 2016

Journal of Endodontics

132

100

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Aims: This systematic review aimed to compare the effectiveness of sodium hypochlorite and chlorhexidine for root canal disinfection during root canal therapy. Methods:A literature search for clinical trials was made on the PUBMED (Medline), Web of Knowledge, SCOPUS, and Science Direct databases and in the reference lists of the identified articles up to January 2015. Quality assessment of the selected studies was carried out according to the CONSORT statement. Results:One clinical trial and four randomized clinical trials (RCTs) were selected from the 172 papers initially identified. There was heterogeneity in the laboratory methods used to assess the root canal disinfection as well as in the concentrations of the irrigants used. Therefore, meta-analysis was not performed. Two studies reported effective and similar reductions in bacterial levels for both irrigants. Sodium hypochlorite was more effective than chlorhexidine to reduce microorganisms in one study and another reported opposite findings. Both root irrigants were ineffective in eliminating endotoxins from necrotic pulp root canals in one study. Trial design and information regarding randomization procedures were not clearly described in the clinical trials. No study compared laboratory results with clinical outcomes. Conclusions:The available evidence on this topic is scarce and the findings of studies were not consistent. Additional RCTs using clinical outcomes to compare the use of sodium hypochlorite and chlorhexidine during root canal therapy are needed.

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Section: Discussionmentioning

confidence: 99%

The Effect of Sodium Hypochlorite and Chlorhexidine as Irrigant Solutions for Root Canal Disinfection: A Systematic Review of Clinical Trials

Gonçalves

Rodrigues

Andrade

et al. 2016

Journal of Endodontics

132

100

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“…It does not necessarily help in this context that sampling procedures to identify the taxa present at specific sites and in different clinical states are full of methodological pitfalls. 29 On the other hand, if these errors are avoided, the root canal space offers a unique opportunity to study opportunistic infections in man.…”

Section: Infection Of the Root Canal Spacementioning

confidence: 99%

On the dynamics of root canal infections—what we understand and what we don't

Zehnder

Belibasakis

2015

Virulence

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“…Fusobacteria and Actinomyces) was evaluated. Sampling from the root canal system is not free from methodological pitfalls [21]. One problem with root canal sampling, as with periodontal sampling, is the fact that microorganisms from sites other than the front of the lesion are collected along with counterparts that cause disease progression.…”

Section: Discussionmentioning

confidence: 99%

Identification of Synergistetes in endodontic infections

Fernandes

Rechenberg

Zehnder

et al. 2014

Microbial Pathogenesis

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The bacterial phylum Synergistetes consists of Gram-negative anaerobes. Oral Synergistetes are divided in two main clusters, namely A and B. Increasing evidence demonstrates their involvement in etiology of oral infections, including apical periodontitis. This condition causes bone loss around the apex of the tooth, subsequent to pulp inflammation (pulpitis). Although the presence of Synergistetes has been confirmed in endodontic infections by molecular methods, these have not been morphologically identified in the affected apical region, and their prevalence among different endodontic infections has not been determined. Therefore, the aim of this study was to evaluate the prevalence, levels and morphology of oral Synergistetes clusters A and B, in apical root canal samples obtained of teeth with irreversible pulpitis, pulp necrosis and apical periodontitis, or previously root-filled teeth with apical periodontitis. For their detection, fluorescence in situ hybridization and epifluorescence microscopy were used. Synergistetes cluster A was not detected in pulpitis, but was found in both apical periodontitis groups, more frequently and at higher ranges in teeth which were previously root filled. Microscopically, they appeared as straight or slightly curved long rods. Synergistetes cluster B was not detected in any of the cases. Fusobacteria and Actinomyces, which are well-established taxa in endodontic infections, were detected more frequently and at higher ranges than Synergistetes. In conclusion, Synergistetes cluster A constitutes part of the mixed apical microbiota in apical periodontitis, and may be involved in its pathogenesis. and epifluorescence microscopy were used. Synergistetes cluster A was not detected in pulpitis, but was found in both apical periodontitis groups, more frequently and at higher ranges in teeth which were previously root filled. Microscopically, they appeared as straight or slightly curved long rods. Synergistetes cluster B was not detected in any of the cases. Fusobacteria and Actinomyces, which are wellestablished taxa in endodontic infections, were detected more frequently and at higher ranges than Synergistetes. In conclusion, Synergstetes cluster A constitutes part of the mixed apical microbiota in apical periodontitis, and may be involved in its pathogenesis.

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How Useful Is Root Canal Culturing in Predicting Treatment Outcome?

Cited by 102 publications

References 53 publications

The Effect of Sodium Hypochlorite and Chlorhexidine as Irrigant Solutions for Root Canal Disinfection: A Systematic Review of Clinical Trials

The Effect of Sodium Hypochlorite and Chlorhexidine as Irrigant Solutions for Root Canal Disinfection: A Systematic Review of Clinical Trials

On the dynamics of root canal infections—what we understand and what we don't

Identification of Synergistetes in endodontic infections

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