Clinical evaluation of teprenone, a mucosal protective agent, in the treatment of patients with gastric ulcers: A nationwide, multicenter clinical study

Shirakabe, H; Takemoto, Tadayoshi; Kobayashi, Kenzo; Ogoshi, Kazuei; Kimura, Ken; Nakamura, Kyoichi; Watanabe, Hidenobu

doi:10.1016/0149-2918(95)80070-0

Cited by 29 publications

(15 citation statements)

References 8 publications

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“…One pharmacological inducer of Hsps is geranylgeranylacetone (GGA). GGA has been safely used in Japan in the clinical treatment of gastric ulcers (Shirakabe et al 1995;Nagasawa et al 1998;Miyake et al 2004;Qian et al 2007). GGA has been shown to induce Hsp70 in variety of tissues, including the gastric mucosa, heart, liver, brain, and cochlea (Hirakawa et al 1996;Ooie et al 2001;Oda et al 2002;Mikuriya et al 2005;Sone et al 2005).…”

Section: Discussionmentioning

confidence: 99%

Hsp70 inhibits aminoglycoside-induced hearing loss and cochlear hair cell death

Taleb

Brandon

Lee

et al. 2009

Cell Stress and Chaperones

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Sensory hair cells of the inner ear are sensitive to death from aging, noise trauma, and ototoxic drugs. Ototoxic drugs include the aminoglycoside antibiotics and the antineoplastic agent cisplatin. Exposure to aminoglycosides results in hair cell death that is mediated by specific apoptotic proteins, including c-Jun N-terminal kinase (JNK) and caspases. Induction of heat shock proteins (Hsps) can inhibit JNK-and caspase-dependent apoptosis in a variety of systems. We have previously shown that heat shock results in robust upregulation of Hsps in the hair cells of the adult mouse utricle in vitro. In addition, heat shock results in significant inhibition of both cisplatin-and aminoglycoside-induced hair cell death. In this system, Hsp70 is the most strongly induced Hsp, which is upregulated over 250-fold at the level of mRNA 2 h after heat shock. Hsp70 overexpression inhibits aminoglycoside-induced hair cell death in vitro. In this study, we utilized Hsp70-overexpressing mice to determine whether Hsp70 is protective in vivo. Both Hsp70-overexpressing mice and their wildtype littermates were treated with systemic kanamycin (700 mg/kg body weight) twice daily for 14 days. While kanamycin treatment resulted in significant hearing loss and hair cell death in wild-type mice, Hsp70-overexpressing mice were significantly protected against aminoglycosideinduced hearing loss and hair cell death. These data indicate that Hsp70 is protective against aminoglycoside-induced ototoxicity in vivo.

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Section: Discussionmentioning

confidence: 99%

Hsp70 inhibits aminoglycoside-induced hearing loss and cochlear hair cell death

Taleb

Brandon

Lee

et al. 2009

Cell Stress and Chaperones

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“…Phytochemical studies carried out on the oleo-resin from Copaifera langsdorffii (ORCL) revealed the presence of a mixture of diterpenes (70%) comprising of kaurenoic (kaur-16-en-19-oic) and polyalthic acids (Gramosa, et al, 1996) and sesquiterpenes (Braga et al, 1998). Some plant extracts that contain diterpenes were shown to exert antimicrobial, antiinflammatory and wound healing effects (Chen et al, 1994;Gu et al, 1995;Shirakabe et al, 1995;Monti et al, 1999). Despite its popular use, there were no published data in support of its wound healing property.…”

Section: Introductionmentioning

confidence: 97%

Investigation on the wound healing activity of oleo‐resin from Copaifera langsdorffi in rats

Paiva

Cunha

Santos

et al. 2002

Phytotherapy Research

101

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The wound healing activity of oleo-resin from Copaifera langsdorffii Desf. (Leguminaceae) bark was evaluated in rats on experimental wounds. The oleo-resin was tested by monitoring wound contraction in excised wounds and by measuring tensile strength in healing incision wounds. The topical application of oleo-resin at a concentration of 4% accelerated wound contraction in open wounds. The mean values of wound contraction in oleo-resin treated rats on day 9 was 84.05% +/- 2.37% as against 51.29% +/- 9.54% seen in controls and the difference was statistically significant (p < 0.05). No significant differences in the rates of wound contraction were observed on days 12, 15, 18 and 21. Also, the tensile strength in healing incised wounds was found to be significantly higher in the group of animals treated with 4% oleo-resin on day 5 but not on days 7 and 12 (controls: 35.95 +/- 7.44 g/cm; oleo-resin: 71.48 +/- 5.77 g/cm; p < 0.05). These results indicate the beneficial effect of C. langsdorffii oleo-resin on wound healing and justify its traditional use for the treatment of wounds.

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“…Chemical extraction studies on the oleoresin revealed the presence of volatile components (8%), β -caryophyllene, caryophyllene oxide, β -elemene, α -cisbergamotene, ar-curcumene and α -trans-bergamotene, and a mixture of diterpenes (70%), kaur-16-en-19-oic (kaurenoic) and polyalthic acids (Gramosa et al, 1996). Natural diterpenes have a therapeutic use in gastric ulcer patients owing to their ability to promote epithelial regeneration of the gastric mucosa (Shirakabe et al, 1995). Our previous studies demonstrated the protective effect of oleoresin against experimentally induced gastric lesions in rats (Paiva et al, 1998).…”

Section: Introductionmentioning

confidence: 98%

Smooth muscle relaxant effect of kaurenoic acid, a diterpene from Copaifera langsdorfﬁi on rat uterus in vitro

Cunha

Paiva

Santos

et al. 2003

Phytotherapy Research

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The effect of kaurenoic acid, a diterpene isolated from the oleo-resin of the popular medicinal plant Copaifera langsdorffii (Leguminaceae), was analysed on rat uterine muscle responsiveness to various drugs in vitro. Cumulative concentration-response curves to acetylcholine and oxytocin were obtained before and after incubation of uterine segments with up to 160 microm of kaurenoic acid. The maximal contractile response (E(max)) evoked by these agonists was inhibited by kaurenoic acid in a concentration-related manner; at 160 microm, kaurenoic acid depressed the E(max) of oxytocin and acetylcholine by 83% and 91%, respectively. The relaxation caused by kaurenoic acid on oxytocin-induced contraction was unaffected in the presence of tetraethyl ammonium, a compound that blocks the calcium activated potassium channels. It was partially reversed by glibenclamide (10(-5) m), an ATP-sensitive potassium channel blocker. Also, kaurenoic acid at 160 microm concentration was found to inhibit significantly the CaCl(2)-evoked contractile responses in a medium of high potassium and zero calcium. Furthermore, kaurenoic acid was found to relax the sustained tonic contraction induced by acetylcholine, oxytocin, BaCl(2) and KCl in a concentration-dependent way. However, KCl-induced tonic contraction was only weakly inhibited by kaurenoic acid. These data indicate that the diterpene, kaurenoic acid, exerts a uterine relaxant effect acting principally through calcium blockade and in part, by the opening of ATP-sensitive potassium channels.

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Clinical evaluation of teprenone, a mucosal protective agent, in the treatment of patients with gastric ulcers: A nationwide, multicenter clinical study

Cited by 29 publications

References 8 publications

Hsp70 inhibits aminoglycoside-induced hearing loss and cochlear hair cell death

Hsp70 inhibits aminoglycoside-induced hearing loss and cochlear hair cell death

Investigation on the wound healing activity of oleo‐resin from Copaifera langsdorffi in rats

Smooth muscle relaxant effect of kaurenoic acid, a diterpene from Copaifera langsdorfﬁi on rat uterus in vitro

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