Clinical evaluation of serum cystatin C and creatinine in patients with chronic kidney disease: A meta-analysis

Zhang, Min; Cao, Xueying; Cai, Guangyan; Wu, Di; Wei, Ri-bao; Xiang, Yuan; Bai, Xueyuan; Liu, Shuwen; Chen, Xiangmei

doi:10.1177/0300060513480922

Cited by 20 publications

(17 citation statements)

References 30 publications

(94 reference statements)

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“…However, most studies used a creatinine-based method for calculating eGFR with widely known limitations. Cystatin C was more sensitive, but less specific, than creatinine for the estimation of eGFR [25]. Serum cystatin C is considered to be a good biomarker in the prediction of kidney function [26].…”

Section: Discussionmentioning

confidence: 99%

Cystatin C and cardiovascular or all-cause mortality risk in the general population: A meta-analysis

Luo

Wang

et al. 2015

Clinica Chimica Acta

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Section: Discussionmentioning

confidence: 99%

Cystatin C and cardiovascular or all-cause mortality risk in the general population: A meta-analysis

Luo

Wang

et al. 2015

Clinica Chimica Acta

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“…An equation containing serum cystatin in combination with serum creatinine, age, sex and race has been proposed by this article as the most accurate estimate. A meta-analysis [9] confirmed a correlation between cystatin C, serum creatinine and GFR in chronic kidney disease cases. According to this meta-analysis, cystatin C was more sensitive, but less specific, than serum creatinine for the estimation of GFR.…”

Section: Discussionmentioning

confidence: 85%

Renal function overestimation in underweight and/or non-ambulatory patients

Keshavarzi

2015

Int J Clin Pharm

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Creatinine clearance estimation is widely used to evaluate the renal function of the patients in order to initiate or adjust the drugs dosage. However serum creatinine, as a muscle metabolism by-product, may not be a reliable parameter in underweight and/or non-ambulatory patients, such as geriatric, acquired immunodeficiency syndrome patients and bed-confined and cachexic cases. To avoid overestimation of the renal function in those patients, serum cystatin C can be considered as a sensitive and accurate alternative for serum creatinine.

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“…Our results are in accordance with the studies carried out. [25][26][27][28][29] The routine classical evaluation of diabetic kidney disease includes appearance of microalbuminuria, decreased creatinine clearance and increased serum creatinine. Many clinicians use serum creatinine in evaluating such patients.…”

Section: Discussionmentioning

confidence: 99%

Cystatin C based eGFR - for early detection of diabetic kidney disease

Shelke

Tele

2019

Int J Res Med Sci

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Background: Diabetic kidney disease is the leading cause of premature death in young diabetic patients. Detection of diabetic kidney disease as early as possible in the disease process currently offers the best chance of delaying or possibly preventing progression to end-stage renal disease. The present study was aimed to evaluate utility of serum cystatin C based eGFR for early diagnosis of diabetic kidney disease.Methods: Diagnosed patients of type 2 diabetes mellitus having frank proteinuria were excluded. Patients without proteinuria were tested for microalbuminuria. 50 patients having microalbuminuria were tested for 24 hour urine creatinine, serum creatinine and serum cystatin C. Both cystatin C based eGFR and eGFR by Cockcroft and Gault equation were compared with standard GFR by 24 hour urine Creatinine clearance respectively.Results: There was statistically significant positive correlation between cystatin C based eGFR and standard GFR by 24 hr Creatinine clearance (r=0.87). For eGFR by Cockcroft-Gault equation, it was 0.36 (r=0.36).Conclusions: The results of this study suggest that serum cystatin C based eGFR measurement is a useful, practical tool for the evaluation of renal involvement in the course of diabetes. As serum creatinine values are affected by many factors like age, sex, muscle mass and diet, serum cystatin C based eGFR estimation offers a hope that diabetic kidney disease can be well prevented with appropriate interventions.

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Clinical evaluation of serum cystatin C and creatinine in patients with chronic kidney disease: A meta-analysis

Abstract: This meta-analysis demonstrated significant correlations between CysC, SCr and GFR. CysC was more sensitive, but less specific, than SCr for the estimation of GFR.

Cited by 20 publications

References 30 publications

Cystatin C and cardiovascular or all-cause mortality risk in the general population: A meta-analysis

Cystatin C and cardiovascular or all-cause mortality risk in the general population: A meta-analysis

Renal function overestimation in underweight and/or non-ambulatory patients

Cystatin C based eGFR - for early detection of diabetic kidney disease

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