Clinical Evaluation of Olfactory Dysfunction at Kagoshima University

Furuta, Shigeru; Hirota, Rikako; Egawa, Masahiko; Ohyama, Masaru; Obata, Etsuro

doi:10.1007/978-4-431-68355-1_252

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1995

2023

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Cited by 3 publications

(2 citation statements)

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“…The original synthetic route 16 of favipiravir consists of seven steps with a complex synthetic process and a fairly low yield of approximately 0.8%. It is not suitable for the production in the current situation.…”

Section: Introductionmentioning

confidence: 99%

Optimized synthesis of anti-COVID-19 drugs aided by retrosynthesis software

Zhai

Dan-na

et al. 2023

RSC Med. Chem.

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Section: Introductionmentioning

confidence: 99%

Optimized synthesis of anti-COVID-19 drugs aided by retrosynthesis software

Zhai

Dan-na

et al. 2023

RSC Med. Chem.

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“…According to the results of several investigators, 47.5% of olfactory disorders can be attributed to sinusitis in Japan (1,2). In sinusitis, the swollen nasal mucosa prevents odorants from reaching the olfactory receptor cells in the olfactory epithelium (OE).…”

Section: Introductionmentioning

confidence: 99%

Uptake of BrdU in Olfactory and Respiratory Epithelium of Rabbits with Experimental Sinusitis

Matsune¹

2000

Acta Oto-Laryngologica

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Sinusitis was induced in six rabbits in order to evaluate its influence on the proliferation of cells in the olfactory epithelium compared with the respiratory epithelium during conservative antibiotic therapy. Then 1% ofloxacin was injected into the paranasal sinuses. Three normal rabbits were not administered any treatment and served as controls. The rabbits were sacrificed under intravenous anesthesia and the olfactory and respiratory mucosa was excised 24 hours after intravenous administration with the labeling reagent 5-bromo-2'-deoxyuridine (BrdU). The extent of cell proliferation in these tissues was estimated by immunohistochemical staining with BrdU-specific antibody. The uptake of BrdU was significantly increased (p = 0.0099) in the respiratory mucosa, but not in the olfactory mucosa. Furthermore, in olfactory epithelium, 79.2% and 16.7% of all BrdU-positive cells were olfactory and basal, respectively. Thus, turnover of epithelial cells due to sinusitis was not as accelerated in the olfactory mucosa as in the respiratory mucosa during antibiotic treatment.

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Olfactory Disturbance Caused by Chronic Sinusitis

Egawa

1995

Nippon Jibiinkoka Gakkai Kaiho

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Clinical Evaluation of Olfactory Dysfunction at Kagoshima University

Cited by 3 publications

References 6 publications

Optimized synthesis of anti-COVID-19 drugs aided by retrosynthesis software

Optimized synthesis of anti-COVID-19 drugs aided by retrosynthesis software

Uptake of BrdU in Olfactory and Respiratory Epithelium of Rabbits with Experimental Sinusitis

Olfactory Disturbance Caused by Chronic Sinusitis

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