Clinical evaluation of enhanced nonablative skin rejuvenation using a combination of a 532 and a 1,064 nm laser

Tan, Mei‐Heng; Dover, Jeffrey S.; Hsu, Te‐Shao; Arndt, Kenneth A.; Stewart, Brigitte

doi:10.1002/lsm.20066

Cited by 45 publications

(41 citation statements)

References 21 publications

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“…Nevertheless, from six randomized controlled trials and four non-randomized controlled trials it seems that non-ablative skin rejuvenation induces a mild to moderate improvement of rhytides lasting up to 6 months after end treatment [4,9,10,21,[28][29][30][31][32][33]. However, blinded evaluations as well as statistical analysis were not performed in all studies.…”

Section: Discussionmentioning

confidence: 99%

Ablative versus non‐ablative treatment of perioral rhytides. A randomized controlled trial with long‐term blinded clinical evaluations and non‐invasive measurements

et al. 2006

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Background and Objective: To compare efficacy and side effects of CO 2 laser resurfacing and intense pulsed light (IPL) rejuvenation for treatment of perioral rhytides. Methods: Twenty-seven female subjects with perioral rhytides (class I-III) were randomly treated with either CO 2 laser or IPL (three monthly treatments). Efficacy was evaluated by patient self-assessments and blinded photographs up to 12 months postoperatively. Side effects were assessed clinically. Non-invasive measurements included: trans epidermal water loss (TEWL), skin reflectance, skin elasticity, and ultrasound. Results: CO 2 laser resurfacing resulted in higher degrees of patient satisfaction and clinical rhytide reduction compared to IPL rejuvenation up to 12 months postoperatively (patient evaluations, P < 0.05) (observer evaluations, P < 0.008). Laser-induced side effects included erythema, dyspigmentation, and milia whereas no side effects were observed after IPL rejuvenation. Non-invasive measurements showed a significant higher reduction of the subepidermal low-echogenic band in CO 2 laser treated areas versus IPL treated areas (12 months postoperatively, P < 0.001). Skin elasticity (expressed as Young's modulus) increased in both groups (P ¼ ns). One month postoperatively a significant increase in TEWL values (P < 0.009) and skin redness% (P < 0.02) was found in CO 2 laser treated patients versus IPL treated patients. No significant differences were seen in skin pigmentation% during the observation period. Conclusion: CO 2 laser resurfacing induces a significantly higher degree of clinical rhytide reduction followed by considerably more side effects compared to IPL rejuvenation in a homogeneous group of patients.

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Section: Discussionmentioning

confidence: 99%

Ablative versus non‐ablative treatment of perioral rhytides. A randomized controlled trial with long‐term blinded clinical evaluations and non‐invasive measurements

et al. 2006

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“…17 Nowadays this radiation is usually employed as a complement to IR laser radiation (Nd:YAG, fundamental mode at 1064 nm) for improvements in the physical signs of photoaging. 30 The ablative effects of 532 nm laser radiation are of lesser extent than those induced with Er:YAG and are located in the more superficial layers, with no contractor effect on collagen. The green light is strongly absorbed by red colored tissue, as well as by hemoglobin, but very little by water: thus, a strategy to increase its absorption in the tissue could be by color enhancement the lesion with red pigments.…”

Section: Discussionmentioning

confidence: 99%

Skin Laser Treatments Enhancing Transdermal Delivery of ALA

Gómez

Costela

García‐Moreno

et al. 2011

Journal of Pharmaceutical Sciences

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“…The selective thermal damage of the dermis is followed by a wound healing response from the damaged tissue, which ultimately leads to new collagen formation. The absence of epidermal damage decreases the severity and degree of side effects that are associated with the treatment [10][11][12][13][14][15]. Although most studies have indicated significant levels of patient satisfaction and even histological and biochemical evidence of improvement, photographic assessment by blinded observers has often found only minimal or no improvement.…”

Section: Discussionmentioning

confidence: 99%

Effects of skin temperature on lesion size in fractional photothermolysis

et al. 2007

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Background and Objectives: Fractional photothermolysis is a new concept in cutaneous re-modeling whereby laser-induced microscopic zones of thermal injury (MTZMicroscopic Treatment Zones) are surrounded by normal, viable tissue. This unique thermal damage pattern allows re-epithelialization in less than 24 hours. To increase patient comfort level during the procedure of fractional photothermolysis, simultaneous skin cooling has been proposed and is now extensively used. The purpose of this in vitro study was to examine the influence of skin temperature on the diameter of the epidermal microthermal zone and the extent of thermal injury per unit area. The determination of the changes in these parameters that are due to skin temperature will allow the better control and understanding of fractional photothermolysis at different skin temperatures. Materials and Methods: Fractional photothermolysis was performed with a 1,550 nm fiber laser (Fraxel SR 1 Laser) with 10 mJ per pulse on full-thickness cadaver skin. The skin samples were brought prior to exposure to temperatures that ranged from 0 to 458C. The epidermis of the skin samples was separated by dispase treatment, stained for thermal damage by NBTC stain, and lesion diameter was assessed by a blinded investigator. Results : The average MTZ diameter exhibits a positive, linear relationship with skin temperature (R 2 ¼ 0.904, P < 0.0001). As the skin temperature increases from 0 to 458C. The MTZ diameter increases from 93 to 147 mm (58%), and the MTZ area from 6,870 to 17,050 mm 2 (148%). Conclusion : The skin temperature affects the size of epidermal MTZs during fractional photothermolysis and is an important variable factor. The use of simultaneous skin cooling increases patient comfort; however, as it also decreases MTZ size, it may interfere with treatment efficacy. The control of skin temperature is necessary to provide a consistent outcome and to be able to compare treatments.

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Clinical evaluation of enhanced nonablative skin rejuvenation using a combination of a 532 and a 1,064 nm laser

Abstract: The 532 nm KTP and 1,064 nm Nd: YAG lasers can be effectively and safely used for non-invasive skin rejuvenation.

Cited by 45 publications

References 21 publications

Ablative versus non‐ablative treatment of perioral rhytides. A randomized controlled trial with long‐term blinded clinical evaluations and non‐invasive measurements

Ablative versus non‐ablative treatment of perioral rhytides. A randomized controlled trial with long‐term blinded clinical evaluations and non‐invasive measurements

Skin Laser Treatments Enhancing Transdermal Delivery of ALA

Effects of skin temperature on lesion size in fractional photothermolysis

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