Clinical Evaluation of Desferrioxamine (DFO) for Removal of Thallium Ions in Rat

Abstract

An investigation was conducted to evaluate the ability of DFO following the administration of thallium salt in male Wistar rats. Thallium was introduced to several groups of weanling male Wistar rats via different means, through drink, food and intraperitoneal injection. A control group was fed on a diet containing a normal level of iron. After a period of 30 days, all the rats administered thallium were severely anemic and showed toxicity symptoms through loss of hair, an increase in thallium and a decrease in iron levels in the blood. Chelation therapy was carried out to remove the toxic element from the body. The ability of desferrioxamine (DFO) in removing thallium was investigated by injection of this chelator for one week to the remaining rats of similar groups. The results showed that the thallium level present in the blood was significantly reduced and, at the same time, the iron concentration returned to the normal level. It was concluded that DFO chelator is able to remove thallium from the body and could be used for the treatment of complications and eradication of symptoms of thallium intoxication.

Chelation of chromium(VI) by combining deferasirox and deferiprone in rats

“…The reason for this important observation is that deferiprone is able to redistribute iron in mammals (Evans et al 2012). In comparison to the results obtained by Fatemi et al (2007, 2009, Tubafard and Fatemi (2008) it can be also concluded that the two chelators (deferasirox ? deferiprone) are more efficient as combined therapy than single therapy in removing chromium from rat organs.…”

“…This kind of therapy by combining two chelators is based on the assumption that various chelating agents mobilize toxic elements from different tissue compartments and therefore better results are expected (Flora et al 1995). Results of this kind of combined chelation therapy have been confirmed by Amiri et al (2007), Fatemi et al (2007Fatemi et al ( , 2009), Tubafard and Fatemi (2008). The aim of the present research was to test the chelation potency of deferasirox and deferiprone in combination, given to animals after chromium loading.…”

“…These ligands promote the excretion and subsequent depletion of this transition metal in biological systems. Clinical evaluations of some chelators for the removal of toxic metal ions in rats have been previously reported by Amiri et al (2007), Fatemi et al (2007Fatemi et al ( , 2009, Shokooh Saljooghi and Fatemi (2010b), Tubafard and Fatemi (2008). These chelating agents consist of a range of bidentate, tridentate and hexadentate ligands in which two, three or six atoms are able to coordinate, respectively (Clarke and Martell 1992;Gomez et al 1988).…”

Clinical evaluation of Deferasirox for removal of cadmium ions in rat

“…It is obvious that the cadmium concentration after chelation therapy was significantly decreased (P < 0.05). To investigate the effect of passing time in removing cadmium from the body spontaneously, one group was treated without chelation therapy (Fatemi et al 2007(Fatemi et al , 2009Tubafard and Fatemi 2008;Tubafard et al 2010). Elimination of cadmium by the biological system in the groups without the chelation therapy is not noticeable (Table 3).…”

“…Clinical evaluations of some chelators for removal of toxic metal ions in rats have been previously reported by (Fatemi et al 2007(Fatemi et al , 2009Tubafard and Fatemi 2008;Tubafard et al 2010). Chelation therapy is one of the most effective ways to remove toxic elements from the biological system.…”