Clinical evaluation of demineralized bone allograft in a hyaluronic acid carrier for sinus lift augmentation in humans: a computed tomography and histomorphometric study

Schwartz, Zvi; Goldstein, Moshe; Raviv, Eli; Hirsch, Ariel E.; Ranly, Don M.; Boyan, Barbara D.

doi:10.1111/j.1600-0501.2006.01303.x

Cited by 95 publications

(110 citation statements)

References 11 publications

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“…4 Settable, weight-bearing bone grafts ideally exhibit both initial bone-like mechanical properties and also remodel with minimal resorption gaps such that the strength of the graft exceeds that of host bone during all stages of healing. Injectable bone void fillers (BVFs) include nonsetting allograft 5 and nonallogenic pastes, 6 which are typically delivered using viscous carriers (e.g., sodium hyaluronate, 7 glycerol, 8 or dextran 9 ) resulting in weak mechanical properties. Resorbable CPCs, [10][11][12][13] such as beta-tricalcium phosphate (b-TCP, slowly resorbed by osteoclasts) or calcium sulfate (CSH) and brushite (undergo dissolution), have also been used to enhance bone healing.…”

Section: Introductionmentioning

confidence: 99%

Balancing the Rates of New Bone Formation and Polymer Degradation Enhances Healing of Weight-Bearing Allograft/Polyurethane Composites in Rabbit Femoral Defects

Dumas

Prieto

Zienkiewicz

et al. 2014

Tissue Engineering Part A

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There is a compelling clinical need for bone grafts with initial bone-like mechanical properties that actively remodel for repair of weight-bearing bone defects, such as fractures of the tibial plateau and vertebrae. However, there is a paucity of studies investigating remodeling of weight-bearing bone grafts in preclinical models, and consequently there is limited understanding of the mechanisms by which these grafts remodel in vivo. In this study, we investigated the effects of the rates of new bone formation, matrix resorption, and polymer degradation on healing of settable weight-bearing polyurethane/allograft composites in a rabbit femoral condyle defect model. The grafts induced progressive healing in vivo, as evidenced by an increase in new bone formation, as well as a decrease in residual allograft and polymer from 6 to 12 weeks. However, the mismatch between the rates of autocatalytic polymer degradation and zero-order (independent of time) new bone formation resulted in incomplete healing in the interior of the composite. Augmentation of the grafts with recombinant human bone morphogenetic protein-2 not only increased the rate of new bone formation, but also altered the degradation mechanism of the polymer to approximate a zero-order process. The consequent matching of the rates of new bone formation and polymer degradation resulted in more extensive healing at later time points in all regions of the graft. These observations underscore the importance of balancing the rates of new bone formation and degradation to promote healing of settable weight-bearing bone grafts that maintain bone-like strength, while actively remodeling.

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Section: Introductionmentioning

confidence: 99%

Balancing the Rates of New Bone Formation and Polymer Degradation Enhances Healing of Weight-Bearing Allograft/Polyurethane Composites in Rabbit Femoral Defects

Dumas

Prieto

Zienkiewicz

et al. 2014

Tissue Engineering Part A

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“…To date, diverse approaches have been attempted to solve these problems caused by using xenogra particles. [7][8][9][10][11][12] One major approach is to employ a physical barrier using non-resorbable materials (e.g., titanium mesh and expanded polytetrauorethylene) or resorbable materials (e.g., collagen membrane, polylactic acid, polyglycolic acid, and polyurethane).…”

Section: Introductionmentioning

confidence: 99%

Engineered mussel bioglue as a functional osteoinductive binder for grafting of bone substitute particles to accelerate in vivo bone regeneration

et al. 2015

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“…It presents osteoinductive and osteoconductive properties. These properties are known experimentally since the work of Urist in the 70s (16)(17)(18)(19). DBX consists in demineralised bone to which an organic carrier is added (sodium hyaluronate).…”

Section: Discussionmentioning

confidence: 99%

“…There is a lot of literature supporting its use as an accelerator of the bone healing. This biomaterial presents multiple applications in oral and craniomaxillofacial surgery (16)(17)(18)(19) . We have noticed that demineralised bone matrix accelerates significantly bone formation in the studied defect.…”

Section: Discussionmentioning

confidence: 99%

A comparative study of platelet-rich plasma, hydroxyapatite, demineralized bone matrix and autologous bone to promote bone regeneration after mandibular impacted third molar extraction.

Arenaz-Búa¹,

Luaces-Rey²,

Sironvalle-Soliva³

et al. 2010

Med Oral

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A comparative study of platelet-rich plasma, hydroxyapatite, demineralized bone matrix and autologous bone to promote bone regeneration after mandibular impacted third molar extraction AbstractObjectives: 1) to compare mandibular bone regeneration by applying autologous bone, platelet-rich plasma and two biomaterials (synthetic calcium hydroxyapatite, and demineralized bone matrix), and thus establish the potential benefits of these biomaterials in the regeneration of postextraction alveolar bone, 2) to identify wich of them accelerates more bone regeneration and 3) to determine whether there are differences in the postoperative period (pain, swelling, trismus, infection) depending on the material used. Study Design: It consists in a prospective, controlled (with a split-mouth design) and double blinded study. We use as a model an easily reproducible non-critical bone defect: the defect that remains after extraction of mandibular impacted third molar. The study design is based on the extraction of two mandibular impacted third molars in a patient during the same surgical procedure by the same surgeon. We assessed postoperative clinical data, and short, medium and long term neoformation of alveolar bone after extraction. We compared the two sockets (right and left), which had been grafted in a different way with the various elements mentioned above. In addition, we compared the postoperative inflammatory symptoms between groups. Results: The highest acceleration in bone formation was observed in groups in which we used autologous bone and demineralized bone matrix. There were no statistically significant differences between groups regarding pain, swelling, trismus and infection throughout the postoperative period. Conclusions: According to the results of our study, autologous bone persists as the gold standard material for bone regeneration. Among the assessed biomaterials, demineralized bone matrix has yielded the best results obtained. No significant differences in the postoperative (pain, swelling, trismus and infectious events) were observed, depending on the type of material used as a graft.

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Clinical evaluation of demineralized bone allograft in a hyaluronic acid carrier for sinus lift augmentation in humans: a computed tomography and histomorphometric study

Abstract: This study confirmed the hypothesis that new bone formation is dependent on the DFDBA formulation used and demonstrated that DBX, alone or in combination with other materials, can be used successfully for sinus floor elevation.

Cited by 95 publications

References 11 publications

Balancing the Rates of New Bone Formation and Polymer Degradation Enhances Healing of Weight-Bearing Allograft/Polyurethane Composites in Rabbit Femoral Defects

Balancing the Rates of New Bone Formation and Polymer Degradation Enhances Healing of Weight-Bearing Allograft/Polyurethane Composites in Rabbit Femoral Defects

Engineered mussel bioglue as a functional osteoinductive binder for grafting of bone substitute particles to accelerate in vivo bone regeneration

A comparative study of platelet-rich plasma, hydroxyapatite, demineralized bone matrix and autologous bone to promote bone regeneration after mandibular impacted third molar extraction.

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