Clinical evaluation of cryosurgery in the treatment of primary liver cancer Report of 60 Cases

Abstract

Of 60 patients, subclinical stage amounted to 35% (21/60), moderate stage 55% (33/60) and late stage 10% (6/60). There were 21 cases with small PLC (15 cm). The postoperative course was uneventful in all of the 60 patients. These was no operative mortality, and there was no complications such as rupture of tumor, secondary bleeding, bile leakage, or abdominal infection. The 1-year, 2-year, 3-year, 4-year, and 5-year survival rates were 51.7% (30/58), 33.9% (19/56), 20.8% (11/53), 15.6% (7/45), and 11.4% (5/44), respectively, for the whole series. Among the 21 patients with tumor nodules 4 cm in diameter, the 1-year, 2-year, 3-year, 4-year, and 5-year survival rates were 76.2% (16/21), 61.9% (13/21), 50.0% (9/18), 41.2% (7/17), and 37.5% (6/16), respectively. These results indicate that hepatic cryosurgery is a promising, safe, and simple treatment for neoplastic disease of liver. Cryosurgery with liquid nitrogen can be considered the surgery of choice for nonresectable PLC in patients without jaundice, ascites, and noncompensated liver function, and the whole tumor mass can be involved in the frozen area.

Surgery of small hepatocellular carcinoma. Analysis of 144 cases

“…It was 10 months (range, [6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22] in patients without reresection calculated from the time of diagnosis to recurrence.…”

World Survey on the Complications of Hepatic and Prostate Cryotherapy

“…During the last 10 years cryotherapy has gained importance especially for treatment of nonresectable primary and secondary liver tumors [2] and for transperineal ablation of the prostate in patients with adenocarcinoma of the prostate [3][4][5][6][7][8]. Cryoablation of the prostate has been reported to be a safe procedure with promising results following cryoablation of prostate cancers with significant tumor marker responses [5,7,8] and 79% to 90% negative biopsy results after 3 to 12 months [5][6][7][8].Hepatic cryotherapy has been shown to be effective for treating colorectal liver metastases [9 -16] and hepatoma [17][18][19]. Results on more than 800 patients have been reported [2] with median survival times of 26 months following cryotherapy of nonresectable colorectal liver metastases [12, 13] and 5-year survival rates of 11.4% to 64.2% [17,18] following cryoablation of hepatoma.…”

“…Results on more than 800 patients have been reported [2] with median survival times of 26 months following cryotherapy of nonresectable colorectal liver metastases [12,13] and 5-year survival rates of 11.4% to 64.2% [17,18] following cryoablation of hepatoma.…”

Interstitial Laser Hyperthermia for the Treatment of Hepatic and Pancreatic Tumours

“…The temperature of the treated area falls to as low as -190°C. Tumour eradication is seen and survival times for otherwise untreatable tumours increased (Ravikumar et al, 1987;Zhou et al, 1988). External radiotherapy to the liver is limited by the problem of toxicity (Sherman et al, 1978) but the interstitial implantation of radioactive seeds has been reported (Dritchilo et al, 1986).…”