Clinical evaluation of bioadhesive ophthalmic drug inserts (BODI®) for the treatment of external ocular infections in dogs

Baeyens, Vincent; Felt-Baeyens, Olivia; Rougier, S; Pheulpin, S; Boisramé, B.; Gurny, Robert

doi:10.1016/s0168-3659(02)00284-5

Cited by 60 publications

(21 citation statements)

References 9 publications

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“…The ocular effectiveness of prepared OFX loaded NLCs and commercial formulation was evaluated by modified Draize test (Baeyens et al, 2002). The test was conducted using a 0 (absence) to 3 (highest) clinical evaluation scale of conjunctival redness and corneal opacity as described in Table 1.…”

Section: Induction Of Experimental Keratitis and Topical Therapymentioning

confidence: 99%

Preparation and in vitro–in vivo evaluation of ofloxacin loaded ophthalmic nano structured lipid carriers modified with chitosan oligosaccharide lactate for the treatment of bacterial keratitis

Okur

Gökçe

Bozbıyık

et al. 2014

European Journal of Pharmaceutical Sciences

146

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Section: Induction Of Experimental Keratitis and Topical Therapymentioning

confidence: 99%

Preparation and in vitro–in vivo evaluation of ofloxacin loaded ophthalmic nano structured lipid carriers modified with chitosan oligosaccharide lactate for the treatment of bacterial keratitis

Okur

Gökçe

Bozbıyık

et al. 2014

European Journal of Pharmaceutical Sciences

146

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“…Baeyens[99] conducted a clinical study in dogs presenting with external ophthalmic diseases (conjunctivitis, superficial corneal ulcer, or keratoconjuctivitissicca) using soluble bioadhesive ophthalmic drug inserts (BODI ® ) in comparison with classical Tiacil ® eye drops from Virbac Laboratories. The results of the clinical study showed that BODI ® demonstrated an advantage over the Tiacil ® by reducing the treatment to a single application and, therefore, improving patient compliance.…”

Section: Ocular Mucoadhesive Drug Delivery Systemsmentioning

confidence: 99%

Mucoadhesive drug delivery systems

et al. 2011

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Mucoadhesion is commonly defined as the adhesion between two materials, at least one of which is a mucosal surface. Over the past few decades, mucosal drug delivery has received a great deal of attention. Mucoadhesive dosage forms may be designed to enable prolonged retention at the site of application, providing a controlled rate of drug release for improved therapeutic outcome. Application of dosage forms to mucosal surfaces may be of benefit to drug molecules not amenable to the oral route, such as those that undergo acid degradation or extensive first-pass metabolism. The mucoadhesive ability of a dosage form is dependent upon a variety of factors, including the nature of the mucosal tissue and the physicochemical properties of the polymeric formulation. This review article aims to provide an overview of the various aspects of mucoadhesion, mucoadhesive materials, factors affecting mucoadhesion, evaluating methods, and finally various mucoadhesive drug delivery systems (buccal, nasal, ocular, gastro, vaginal, and rectal).

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“…The therapeutics requires the association of more than one antimicrobial treatment for several weeks, which often leads to poor patient compliance, contributing to low therapy efficiency (5). In order to overcome the problems of conventional ocular therapy, such as short residence time, loss of drug through nasolacrimal drainage, impermeability of corneal epithelium and frequent instillation; newer ocular delivery systems for gentamicin are being explored by many researchers (6)(7)(8). It is now common knowledge that topical controlled delivery of ophthalmic drugs improves their ocular bioavailability with respect to traditional eye drops, by decreasing the rate of drug elimination from the precorneal area (9).…”

Section: Introductionmentioning

confidence: 99%

Niosome-Encapsulated Gentamicin for Ophthalmic Controlled Delivery

2008

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Abstract. The objective of the present research was to investigate the feasibility of using non-ionic surfactant vesicles (niosomes) as carriers for the ophthalmic controlled delivery of a water soluble local antibiotic; gentamicin sulphate. Niosomal formulations were prepared using various surfactants (Tween 60, Tween 80 or Brij 35), in the presence of cholesterol and a negative charge inducer dicetyl phosphate (DCP) in different molar ratios and by employing a thin film hydration technique. The ability of these vesicles to entrap the studied drug was evaluated by determining the entrapment efficiency %EE after centrifugation and separation of the formed vesicles. Photomicroscopy and transmission electron microscopy as well as particle size analysis were used to study the formation, morphology and size of the drug loaded niosomes. Results showed a substantial change in the release rate and an alteration in the %EE of gentamicin sulphate from niosomal formulations upon varying type of surfactant, cholesterol content and presence or absence of DCP. In-vitro drug release results confirmed that niosomal formulations have exhibited a high retention of gentamicin sulphate inside the vesicles such that their in vitro release was slower compared to the drug solution. A preparation with 1:1:0.1 molar ratio of Tween 60, cholesterol and DCP gave the most advantageous entrapment (92.02%±1.43) and release results (Q 8h =66.29%±1.33) as compared to other compositions. Ocular irritancy test performed on albino rabbits, showed no sign of irritation for all tested niosomal formulations.

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Clinical evaluation of bioadhesive ophthalmic drug inserts (BODI®) for the treatment of external ocular infections in dogs

Cited by 60 publications

References 9 publications

Preparation and in vitro–in vivo evaluation of ofloxacin loaded ophthalmic nano structured lipid carriers modified with chitosan oligosaccharide lactate for the treatment of bacterial keratitis

Preparation and in vitro–in vivo evaluation of ofloxacin loaded ophthalmic nano structured lipid carriers modified with chitosan oligosaccharide lactate for the treatment of bacterial keratitis

Mucoadhesive drug delivery systems

Niosome-Encapsulated Gentamicin for Ophthalmic Controlled Delivery

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