Clinical Evaluation of Application of Polyglycolic Acid Sheet and Fibrin Glue Spray for Partial Glossectomy

Takeuchi, Junichiro; Suzuki, Hiroaki; Murata, Maho; Kakei, Yasumasa; Ri, Shinshou; Umeda, Masahiro; Komori, Takahide

doi:10.1016/j.joms.2012.08.012

Cited by 59 publications

(49 citation statements)

References 9 publications

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“…PGA sheets are hydrolyzed in vivo , with subsequent degradation and absorption, and their coating effect is known to be enhanced if they are applied in combination with FG [24]. This combined PGA-FG therapy has been widely used in multiple surgical fields, and several studies have reported on its safety and efficacy [7, 9, 25,26,27]. In addition, PGA-FG composites have been utilized as sealants during orthopedic surgery and as a means of achieving hemostasis during liver and pancreatic surgery [31].…”

Section: Introductionmentioning

confidence: 99%

Comparison of the wound healing efficacy of polyglycolic acid sheets with fibrin glue and gelatin sponge dressings in a rat cranial periosteal defect model

et al. 2016

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Oral surgical procedures occasionally require removal of the periosteum due to lesions, and these raw bone surfaces are prone not only to infection but also to scar formation during secondary healing. The objective of this study was to identify successful methods for reconstruction using periosteal defect dressings. We created 1-cm2 defects in the skin and cranial periosteum of 10-week-old male Wistar rats under isoflurane anesthesia. The animals were assigned to three defect treatment groups: (1) polyglycolic acid sheets with fibrin glue dressing (PGA-FG), (2) Spongel® gelatin sponge dressing (GS), and (3) open wound (control). Postoperative wound healing was histologically evaluated at 2, 4, and 6 weeks. The moist conditions maintained by the GS and PGA-FG treatments protected the bone surface from the destructive effects of drying and infection. Complete wound healing was observed in the GS group but not for all animals in the PGA-FG and control groups. Histologically, osteoblast proliferation on bone surfaces and complete epithelialization with adnexa were observed in the GS group at 6 weeks after surgery. In contrast, PGA sheets that had not been absorbed inhibited osteoblast proliferation and delayed wound healing in the PGA-FG group. Wound surface dressings maintain a moist environment that promotes wound healing, but PGA materials may not be suitable for cases involving exposed periosteum or bone surfaces due to the observed scar formation and foreign-body reaction.

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Section: Introductionmentioning

confidence: 99%

Comparison of the wound healing efficacy of polyglycolic acid sheets with fibrin glue and gelatin sponge dressings in a rat cranial periosteal defect model

et al. 2016

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“…[1] and Shinozaki et al . [5] During the preoperative informed consent process, we explained to each patient the risk of blood-borne diseases with the use of fibrin glue.…”

Section: Methodsmentioning

confidence: 99%

“…The excision area (cm 2 ) was calculated using the formula proposed by previous studies:[19] major length (cm) × minor length (cm) × π/4 of the surgical specimen.…”

Section: Methodsmentioning

confidence: 99%

“…Alternatives such as mucosal grafts, or skin grafts, are less ideal due to the formation of contractures, which lead to functional disabilities. [1] For oral cavity reconstruction, STSG has been the gold standard for managing medium-sized defects. [2]…”

Section: Introductionmentioning

confidence: 99%

“…There were only a few previous studies involving <10 cases of the application of a PGA sheet for soft tissue repair such as repair of the upper gingiva,[910] lower gingiva,[5910] floor of mouth,[5] buccal mucosa,[59] soft and hard palate,[5910] and at the most, 30 cases of coverage of a lingual surgical defect. [11112] Evaluation and analysis of the defect size in studies on a PGA sheet varied among researchers. Rokutanda et al .…”

Section: Introductionmentioning

confidence: 99%

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Clinical evaluation of coverage of open wounds: Polyglycolic acid sheet with fibrin glue spray vs split thickness skin

Mochizuki

Tomioka

Tushima

et al. 2016

Ann Maxillofac Surg

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Purpose:This study aimed to evaluate the coverage of oral wounds using either a polyglycolic acid (PGA) sheet or split-thickness skin grafting (STSG).Materials and Methods:A total of 119 cases of wound coverage using a PGA sheet and fibrin glue spray as well as 132 cases of wound coverage cases using STSG were reviewed retrospectively. The site of the excision area, perioperative conditions, and postoperative functional problems were evaluated.Results:The PGA group had significantly shorter operation time, earlier start of oral intake, and shorter hospitalization than the STSG group. If the PGA sheet over the wound with exposed bone could be protected by a surgical sprint, oral food intake could be started on the day after surgery at the earliest. When the size of the wound in the buccal excisional area was classified into two groups (<6 or ≥6 cm2), mouth opening in the STSG group was significantly larger at 3 months postoperatively. When the size of the wound in the tongue and floor of mouth was classified into two groups (<12 or ≥12 cm2), the STSG group had a significantly higher score in postoperative speech intelligibility.Conclusion:Selection of a PGA sheet or STSG based on the consideration of defect size, tumor location, patients’ local and general condition and tolerance for surgery could reduce the patients’ postsurgical dysfunctional problems.

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Applications of Biodegradable Polymers and Plastics

Saini

Kaur²,

Singh

et al. 2022

Biodegradable Materials and Their Applications

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Clinical Evaluation of Application of Polyglycolic Acid Sheet and Fibrin Glue Spray for Partial Glossectomy

Cited by 59 publications

References 9 publications

Comparison of the wound healing efficacy of polyglycolic acid sheets with fibrin glue and gelatin sponge dressings in a rat cranial periosteal defect model

Comparison of the wound healing efficacy of polyglycolic acid sheets with fibrin glue and gelatin sponge dressings in a rat cranial periosteal defect model

Clinical evaluation of coverage of open wounds: Polyglycolic acid sheet with fibrin glue spray vs split thickness skin

Applications of Biodegradable Polymers and Plastics

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