Comparison of the wound healing efficacy of polyglycolic acid sheets with fibrin glue and gelatin sponge dressings in a rat cranial periosteal defect model

Abstract

Oral surgical procedures occasionally require removal of the periosteum due to lesions, and these raw bone surfaces are prone not only to infection but also to scar formation during secondary healing. The objective of this study was to identify successful methods for reconstruction using periosteal defect dressings. We created 1-cm2 defects in the skin and cranial periosteum of 10-week-old male Wistar rats under isoflurane anesthesia. The animals were assigned to three defect treatment groups: (1) polyglycolic acid sheets with fibrin glue dressing (PGA-FG), (2) Spongel® gelatin sponge dressing (GS), and (3) open wound (control). Postoperative wound healing was histologically evaluated at 2, 4, and 6 weeks. The moist conditions maintained by the GS and PGA-FG treatments protected the bone surface from the destructive effects of drying and infection. Complete wound healing was observed in the GS group but not for all animals in the PGA-FG and control groups. Histologically, osteoblast proliferation on bone surfaces and complete epithelialization with adnexa were observed in the GS group at 6 weeks after surgery. In contrast, PGA sheets that had not been absorbed inhibited osteoblast proliferation and delayed wound healing in the PGA-FG group. Wound surface dressings maintain a moist environment that promotes wound healing, but PGA materials may not be suitable for cases involving exposed periosteum or bone surfaces due to the observed scar formation and foreign-body reaction.

Endoscopic Sealing With a Polyglycolic Acid Sheet for Restoration of Vocal Fold Mucosa in Dogs

“…The wound-healing efficacy of PGA sheets used in conjunction with fibrin glue has been histologically demonstrated in a rat cranial periosteal defect model. 31 In that study, although PGA-induced scar formation and a foreign-body reaction were observed 6 weeks after surgery, the PGA group showed better wound healing compared with the control group. Yet, as it generally takes 15 weeks for the PGA sheet to be completely absorbed under physiological conditions, histological results over a longer period of time will be needed.…”

“…However, few studies have reported on the process of healing after wound sealing with PGA sheets in vivo. The wound‐healing efficacy of PGA sheets used in conjunction with fibrin glue has been histologically demonstrated in a rat cranial periosteal defect model . In that study, although PGA‐induced scar formation and a foreign‐body reaction were observed 6 weeks after surgery, the PGA group showed better wound healing compared with the control group.…”

Effects of Impacted Lower Third Molar Extraction on Periodontal Tissue of the Adjacent Second Molar

“… 62 Studies have shown that filling the collagen sponge after ILTM extraction benefits the migration of osteoblasts, stabilizes blood clots, promotes soft tissue healing, and protects wounds and bone reconstruction. 63 Clinically, collagen sponge has been mainly used to prevent and repair periodontal defects. Wang et al 64 have found that the alveolar bone loss in the experimental group (filling collagen sponge after the mesial ILTM extraction) was significantly reduced compared with the control group, indicating that collagen sponge prevents postoperative periodontal defects and maintains the periodontal health of the second molars.…”

Comparison of the wound-healing efficacy of gelatin sponge dressings and that of artificial dermis using atelocollagen in a rat cranial periosteal defect model

“…In light of the above information, new wound dressings have been active ly developed since the early 1980s to prom ote wound healing [7]. In a previous study, we prepared 100 -mm 2 wounds with exposed bone surfaces on the heads of rats; the wounds were covered with gelatin sponge (GS ; the GS group ), PGA sheets with fibrin glue dr essing 6 (PGA-FG; the PGA -FG group ), or were left open (the cont rol group ); and the healing process of the wound aft er 2, 4 , and 6 weeks was observed macros copically and microscopically in each group [8]. Our findings showed that wound healing was complet ed earlier in the GS group than in the other groups [8].…”

“…In a previous study, we prepared 100 -mm 2 wounds with exposed bone surfaces on the heads of rats; the wounds were covered with gelatin sponge (GS ; the GS group ), PGA sheets with fibrin glue dr essing 6 (PGA-FG; the PGA -FG group ), or were left open (the cont rol group ); and the healing process of the wound aft er 2, 4 , and 6 weeks was observed macros copically and microscopically in each group [8]. Our findings showed that wound healing was complet ed earlier in the GS group than in the other groups [8]. In this study aim ed at finding wound dressing materials with a wound -healing effect superior to that of GS, artificial dermis Terudermis ® (AD-T, a graft for dermal defects, which is made from processed bovi ne dermis -derived collagen) was used, and its wound-healing effect was compared to that of GS.…”