Clinical-Epidemiological Relation Between Sars-Cov-2 and Kawasaki Disease: An Integrative Literature

Abstract

Objective: To analyze the current scientific literature to document, in an integrative review, the main findings that correlate Kawasaki disease (KD) to COVID-19. Data sources: The search was carried out in June 2020 in the following databases: Biblioteca Virtual em Saúde (BVS), periódico da CAPES and U.S National Library of Medicine (PubMed). The combination of descriptors used was [(COVID-19 OR SARS-CoV-2) AND (Kawasaki disease)], and the inclusion criteria stipulated were studies published from January 2019 to June 2020, without restriction of language or location, and available online in full. News, editorials, comments, and letters, as well as duplicates and articles that did not answer the guiding question were excluded. Data synthesis: A total of 97 articles were identified, of which seven comprised this review. The association of KD to the new coronavirus appears to trigger a severe clinical condition of vasculitis. Different from the usual, in this inflammatory syndrome, patients are older, and prevalence is higher in children from African or Caribbean ancestry; clinical and laboratory manifestations are also atypical, with a predominance of abdominal complaints and exaggerated elevation of inflammatory markers. In addition, there was a greater report of rare complications and greater resistance to the recommended treatment for KD. Conclusions: Pediatric COVID-19 and its potential association to severe KD, still unfamiliar to health professionals, reinforces the importance of testing patients with vasculitis for the new coronavirus and the need to wage high surveillance and preparation of the health system during the current pandemic.

Oral manifestations detected in COVID-19 patients: an integrative review

“…More than 206.757 patients were considered in this review and there was a wide variation in the audience analyzed, probably due to the large variability of studies included, from case reports (Amorim Dos Santos et al, 2021;Amorim dos Santos et al, 2020a;Cebeci Kahraman, Özen, et al, 2020;Cherif et al, 2020;Chern et al, 2020;Cirillo et al, 2021b;Cruz Tapia et al, 2020;Eghbali Zarch & Hosseinzadeh, 2021b;Kitakawa et al, 2020b;Moreira et al, 2020b;Ramires et al, 2021) to clinical studies (Karadas et al, 2020;Marouf et al, 2021). There were no restrictions regarding the gender investigated by the studies, nor were there any discrepancies regarding this information to the course of the disease, clinical manifestations or even the severity of the outcome found.…”

“…While some focused on biomolecular (L. Chen et al, 2020a;Fernandes Matuck et al, 2020) others emphasized the clinical aspects and aspects of the disease itself, its possible associations and its consequences (Amorim Dos Santos et al, 2021;Amorim dos Santos et al, 2020a;Cebeci Kahraman, Özen, et al, 2020;Lechien et al, 2020a;Manzalawi et al, 2020;Pang et al, 2020).…”

Clinical Manifestations of COVID-19 in the Feet: A Review of Reviews

“…Ten reviews were evaluated, 1 systematic review [30] and 9 narrative reviews [6][7][8][9][26][27][28][29], with one being eliminated for low quality, (AMSTAR 1 score < 8) [25]; the rest were of high quality (AMSTAR 1 score ≥ 8). The methodological quality of each review was chosen according to the summary in Figure 2.…”

“…After the AMSTAR 1 criteria were applied by two researchers independently, 1 article [25] was excluded for only meeting 7 of the 11 criteria to be evaluated (7/11), which is a lowquality indicator. A total of nine articles [6][7][8][9][26][27][28][29][30] were included in this review of reviews, of which only one was a systematic review [30] and eight were narrative reviews of the literature.…”

Manifestação da Doença de Kawasaki sob espectro clínico da Covid-19: uma revisão sistemática de literatura

“…A doença apresenta uma característica multissistêmica, e que se manifesta em qualquer idade, sendo mais grave em indivíduos idosos e com presença de comorbidades (Volpat et al, 2020). A Sars-CoV-2 nos adultos geralmente afeta o trato respiratório, causando pneumonia e os sintomas mais comumente encontrados são febre baixa, tosse, odinofagia e fadiga, já as crianças apresentam-se como assintomáticas ou uma sintomatologia leve, como febre intermitente, infecção de vias aéreas superiores e pneumonia sem hipoxemia (Santos et al, 2020). Contudo, após uma análise de crianças acometidas pela Covid-19, o quadro de hiperinflamação apresentado demonstrou alterações nas artérias coronárias, característica da doença de Kawasaki (Volpat et al, 2020).…”