Clinical, epidemiological, and microbiological profile of patients with vancomycin-resistant Enterococci from a Tertiary Care Hospital

Vidyalakshmi, PR; Gopalakrishnan, Ram; Ramasubramanian, V; Ghafur, K. Abdul; Nambi, P Senthur; Thirunarayana, MA

doi:10.4103/0974-777x.96784

Cited by 14 publications

(6 citation statements)

References 4 publications

(5 reference statements)

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“…Recent Indian studies have reported that the majority of the VRE isolates recovered from hospitalized patients were found to be E. faecium [7][8][9]. However, we report a case of vancomycin resistant E. faecalis CAUTI.…”

Section: Discussioncontrasting

confidence: 38%

Clinico-Microbiological Investigation of Catheter Associated Urinary Tract Infection by Enterococcus faecalis : vanA Genotype

Padmavathy

Praveen

Madhavan

et al. 2015

JCDR

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Section: Discussioncontrasting

confidence: 38%

Clinico-Microbiological Investigation of Catheter Associated Urinary Tract Infection by Enterococcus faecalis : vanA Genotype

Padmavathy

Praveen

Madhavan

et al. 2015

JCDR

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“… 9 Though the rate of isolation of VRE is currently not very high in India when compared to other countries (USA and Europe), still it is definitely on an increasing side. 10 It was found that the mortality and morbidity are more with VRE bacteremia. 11 Therefore, in this study, we analyzed the current trends of VRE bacteremia, the clinical, microbiological, and epidemiological features of the VRE culture-positive patients in a tertiary care center in South India.…”

Section: Introductionmentioning

confidence: 99%

Increasing Trend of Vancomycin-resistant Enterococci Bacteremia in a Tertiary Care Hospital of South India: A Three-year Prospective Study

Sivaradjy¹,

Gunalan²,

Priyadarshi³

et al. 2021

Indian Journal of Critical Care Medicine

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Introduction: Vancomycin-resistant enterococci (VRE) are emerging as an important multidrug-resistant pathogen causing nosocomial infections, predominantly bacteremia and urinary tract infections. VRE bacteremia has caused a significant increase in the duration of the hospital stay and mortality and had caused high public health threat due to limited treatment options. Materials and methods: Between October 2017 and September 2020, all consecutive patients with culture-proven bloodstream infection with Enterococcus species, isolated for the first time, were included in the study. A total of 427 Enterococcus species were identified, and antimicrobial susceptibility tests were performed and interpreted using Clinical and Laboratory Standard Institute guidelines. Results: Of the total 427 Enterococcus species isolated, 63 (45.6%) were VRE. Among them, 51/63 (81%) were Enterococcus faecium ( E. faecium ) and 5/63 (8%) were Enterococcus faecalis . There was an increased trend of VRE rate in the bloodstream infections of 6.12% (2018), 13.2% (2019), and 19.2% (2020). The majority of the VRE patients [43/63 (68%)] were admitted to the intensive care units (ICUs). Vancomycin A (VanA) is the most common phenotype isolated from 51/63(81%) patients. Conclusion: This increasing trend of VRE bacteremia is a red alert to the clinicians and the infection control practitioners, so that strict antibiotic policies and proper adherence to the infection control practices can be initiated to reduce the VRE rate. How to cite this article: Sivaradjy M, Gunalan A, Priyadarshi K, Madigubba H, Rajshekar D, Sastry AS. Increasing Trend of Vancomycin-resistant Enterococci Bacteremia in a Tertiary Care Hospital of South India: A Three-year Prospective Study. Indian J Crit Care Med 2021;25(8):881–885.

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“…Various studies from India reported vancomycin resistance in a range of 1.7-20%. 20 However, in a study conducted by Deshpande et al, 17 less than 2% of E. faecalis were found to be resistant to vancomycin, whereas 52% of the E. faecium isolates were resistant to vancomycin. The frequency and extent of glycopeptides resistance in a study conducted by Deshpande et al, 17 were much higher compared to those of previous reports from India.…”

Section: Resultsmentioning

confidence: 99%

Antibiogram of Enterococcal Species Isolated From Clinical Specimens in a Tertiary Care Teaching Hospital

Maruthamuthu¹,

Kavita²,

Mohiddin³

2016

jemds

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BACKGROUNDEnterococci are Gram-positive cocci that are normal inhabitants of the gastrointestinal tract. Enterococci have become the second most common agent recovered from nosocomial UTI and wound infections and the third leading cause of bacteraemia. Although, enterococci have been considered of relatively low virulence, these organisms can cause serious infections including endocarditis. In the last few decades, the number of serious infections caused by these organisms has been steadily increasing. Resistance to several commonly used antibiotics is a remarkable characteristic of most of the enterococcal species. We aimed at determining the isolation rate and resistance pattern of Enterococcal species to different antibiotics from clinical specimens.

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Clinical, epidemiological, and microbiological profile of patients with vancomycin-resistant Enterococci from a Tertiary Care Hospital

Cited by 14 publications

References 4 publications

Clinico-Microbiological Investigation of Catheter Associated Urinary Tract Infection by Enterococcus faecalis : vanA Genotype

Clinico-Microbiological Investigation of Catheter Associated Urinary Tract Infection by Enterococcus faecalis : vanA Genotype

Increasing Trend of Vancomycin-resistant Enterococci Bacteremia in a Tertiary Care Hospital of South India: A Three-year Prospective Study

Antibiogram of Enterococcal Species Isolated From Clinical Specimens in a Tertiary Care Teaching Hospital

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