Clinical Entity of Cryptogenic Mycotic Aneurysm

Blum, Lester; Keefer, Edward B. C.

doi:10.1001/jama.1964.03060320027006

Cited by 21 publications

(5 citation statements)

References 3 publications

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“…According to recent studies, pathogen testing indicates that Salmonella is the leading cause of aneurysm, comprising 75% of the cases. 4 The patient in the case report was verified to have ADA by contrastenhanced CT of the chest and detection of Salmonella infection by blood culture. The case presents mycotic aneurysm due to Salmonella infection.…”

Section: Discussionmentioning

confidence: 83%

“…5 In addition to Salmonella, Staphylococcus aureus and Streptococcus rank as the second and third leading pathogenic bacteria causing mycotic aneurysm, with 16% and 5% rates of occurrence, respectively. 4 S. aureus mainly causes infection through risk factors such as repeated injection and arterial vascular damage, whereas Streptococcus is usually related to bacterial endocarditis. The infected region was often confirmed by tissue pathology and germiculture after surgery but not before the procedure, which may be traced back to the fact that the focus of infection is usually located inside the atheroma, causing a negative blood culture; consequently, the occurrence of ADA is either reduced or underestimated.…”

Section: Discussionmentioning

confidence: 99%

“…However, 25% of germicultures exhibit electronegativity. 4 The case discussed is Salmonellapositive only according to serology.…”

Section: Discussionmentioning

confidence: 99%

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Aortic dissection with aneurysm associated with Salmonella infection

Guo

Wang

et al. 2017

Eur J Inflamm

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This case report presents aortic dissection with aneurysm (ADA) related to Salmonella infection. An 84-year-old male patient was admitted to our hospital for fever and chest pain. Chest computed tomography (CT) showed ADA. The patient underwent aortic dissection and cavity isolation surgery; subsequently, the patient was found to be febrile. Blood culture detected the presence of Salmonella infection. We concluded that the case presented was mycotic aneurysm due to Salmonella infection.

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Section: Discussionmentioning

confidence: 83%

Section: Discussionmentioning

confidence: 99%

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Aortic dissection with aneurysm associated with Salmonella infection

Guo

Wang

et al. 2017

Eur J Inflamm

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“…For example, in patients (nonaddicts) judged to have normal valves or presenting similar lesions in the two sides of the heart, the risk of developing endocarditis is greater in the left side (17,32). Infections in arteries are rare (3,4,5,30) apart from those associated with anatomic abnormalities (23), this despite the common finding of fibrin-platelet VEGS overlying ulcerated arteriosclerotic plaques in the abdominal aorta (25). In humans, it is well known that the removal of catheters (28) or prosthetic heart valves facilitates the sterilization of infections associated with them; this lends a particular interest to the role of the catheter in these experiments.…”

Section: Resultsmentioning

confidence: 99%

“…In drug addicts with endocarditis, staphylococci usually localize in the right side of the heart, and streptococci usually localize in the left (6,24). In several studies of primary mycotic aneurisms, salmonellae were responsible for the majority of infections (3,5,20), whereas they rarely produce infection within the heart (29).…”

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confidence: 99%

Streptococcal infection of endocardial and other intravascular vegetations in rabbits: natural history and effect of dexamethasone

Francioli¹,

Freedman²

1979

Infect Immun

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Experiments were designed to study the natural history of infection in different parts of the vascular system. Sterile vegetations were produced in rabbits by placing catheters in the inferior vena cava, tricuspid or aortic valves, and thoracic or abdominal aorta and then were infected by the intravenous inoculation of Streptococcus sanguis. At 1 day after bacterial challenge, all VEGS were infected, mean bacterial densities being highest in the VEGS of the aortic and tricuspid valves. By 14 days, there was a significant decrease in the mean bacterial density in all VEGS except for the aortic valve: the VEGS of the inferior vena cava and abdominal aorta were sterile, as were half of those of the thoracic aorta. There were no deaths except for animals with aortic valve infection. Dexamethasone inhibited the sterilization of the thoracic aorta VEGS, but was without effect on aortic valve VEGS, 5 mm distant. Sterilization of tricuspid valve VEGS after catheter removal was also inhibited by dexamethasone. Thus, there are host defense mechanisms which lead to the sterilization of infections everywhere in the vascular system except in the left side of the heart, and these mechanisms, as yet undefined, are inhibited by dexamethasone.

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Mycotic Aneurysms-A Challenge and a Clue

Cliff¹

1970

Arch Intern Med

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Clinical Entity of Cryptogenic Mycotic Aneurysm

Cited by 21 publications

References 3 publications

Aortic dissection with aneurysm associated with Salmonella infection

Aortic dissection with aneurysm associated with Salmonella infection

Streptococcal infection of endocardial and other intravascular vegetations in rabbits: natural history and effect of dexamethasone

Mycotic Aneurysms-A Challenge and a Clue

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