Clinical Electromyography

Aminoff, Michael J.

doi:10.1016/b978-1-4557-0308-1.00011-x

Cited by 12 publications

(12 citation statements)

References 98 publications

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“…Oxford Synergy Medelec, UK electromyography equipment was used and detailed nerve conduction studies and needle examination were performed using standard protocol. [ 13 ]…”

Section: Methodsmentioning

confidence: 99%

Limb-girdle muscular dystrophy in the Agarwals: Utility of founder mutations in CAPN3 gene

Khadilkar

Chaudhari

Dastur

et al. 2016

Ann Indian Acad Neurol

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Background and Purpose:Diagnostic evaluation of limb-girdle muscular dystrophy type 2A (LGMD2A) involves specialized studies on muscle biopsy and mutation analysis. Mutation screening is the gold standard for diagnosis but is difficult as the gene is large and multiple mutations are known. This study evaluates the utility of two known founder mutations as a first-line diagnostic test for LGMD2A in the Agarwals.Materials and Methods:The Agarwals with limb-girdle muscular dystrophy (LGMD) phenotype were analyzed for two founder alleles (intron 18/exon 19 c.2051-1G>T and exon 22 c.2338G>C). Asymptomatic first-degree relatives of patients with genetically confirmed mutations and desirous of counseling were screened for founder mutations.Results:Founder alleles were detected in 26 out of 29 subjects with LGMD phenotype (89%). The most common genotype observed was homozygous for exon 22 c.2338 G>C mutation followed by compound heterozygosity. Single founder allele was identified in two. Single allele was detected in two of the five asymptomatic relatives.Conclusion:Eighty-nine percent of the Agarwals having LGMD phenotype have LGMD2A resulting from founder mutations. Founder allele analysis can be utilized as the initial noninvasive diagnostic step for index cases, carrier detection, and counseling.

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“…Oxford Synergy Medelec, UK electromyography equipment was used and detailed nerve conduction studies and needle examination were performed using standard protocol. [ 13 ]…”

Section: Methodsmentioning

confidence: 99%

Limb-girdle muscular dystrophy in the Agarwals: Utility of founder mutations in CAPN3 gene

Khadilkar

Chaudhari

Dastur

et al. 2016

Ann Indian Acad Neurol

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“…Zur Vertiefung sei hier verwiesen auf Lehrbücher der klinischen Elektroneurophysiologie [1][2][3][4][5][6].…”

Section: Leitsymptomunclassified

Diagnose von Myopathie und Myasthenie

Erdmann

2014

Das Neurophysiologie-Labor

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“…Currently, the clinical evaluation of peripheral nerve injury relies primarily on clinical history, clinical symptoms, and physical/neurological examination ( Aminoff, 2012 ; Zeidenberg et al, 2015 ). Clinical symptoms usually include neuromuscular physiology state, special body posture, motor and sensory function, and reflex issues ( Sallomi et al, 1998 ).…”

Section: Introductionmentioning

confidence: 99%

Quantitative Assessment of Traumatic Upper-Limb Peripheral Nerve Injuries Using Surface Electromyography

Tang

Zhang

Yong

et al. 2020

Front. Bioeng. Biotechnol.

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Background: There is a great demand for convenient and quantitative assessment of upper-limb traumatic peripheral nerve injuries (PNIs) beyond their clinical routine. This would contribute to improved PNI management and rehabilitation. Objective: The aim of this study was to develop a novel surface EMG examination method for quantitatively evaluating traumatic upper-limb PNIs. Methods: Experiments were conducted to collect surface EMG data from forearm muscles on both sides of seven male subjects during their performance of eight designated hand and wrist motion tasks. All participants were clinically diagnosed as unilateral traumatic upper-limb PNIs on the ulnar nerve, median nerve, or radial nerve. Ten healthy control participants were also enrolled in the study. A novel framework consisting of two modules was also proposed for data analysis. One module was first used to identify whether a PNI occurs on a tested forearm using a machine learning algorithm by extracting and classifying features from surface EMG data. The second module was then used to quantitatively evaluate the degree of injury on three individual nerves on the examined arm. Results: The evaluation scores yielded by the proposed method were highly consistent with the clinical assessment decisions for three nerves of all 34 examined arms (7 × 2 + 10 × 2), with a sensitivity of 81.82%, specificity of 98.90%, and significate linear correlation (p < 0.05) in quantitative decision points between the proposed method and the routine clinical approach. Conclusion: This study offers a useful tool for PNI assessment and helps to promote extensive clinical applications of surface EMG.

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Clinical Electromyography

Cited by 12 publications

References 98 publications

Limb-girdle muscular dystrophy in the Agarwals: Utility of founder mutations in CAPN3 gene

Limb-girdle muscular dystrophy in the Agarwals: Utility of founder mutations in CAPN3 gene

Diagnose von Myopathie und Myasthenie

Quantitative Assessment of Traumatic Upper-Limb Peripheral Nerve Injuries Using Surface Electromyography

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