Clinical Efficacy of Subgingivally Delivered 1.2‐mg Simvastatin in the Treatment of Individuals With Class II Furcation Defects: A Randomized Controlled Clinical Trial

Pradeep, A.R.; Priyanka, N; Kalra, Nitish; Naik, Savitha B.; Singh, Sonender Pal; Martande, Santosh S.

doi:10.1902/jop.2012.110716

Cited by 68 publications

(137 citation statements)

References 33 publications

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“…[23] Furthermore, the study demonstrated a greater decrease in gingival index and PD, more attachment gain and signifi cant bone fi ll with locally delivered simvastatin in patients with Class II furcation defects. [24] In the present study, the OSIRIS index was used to assess the risk for osteoporosis in postmenopausal women and found that late postmenopausal women (>5 years) were at a higher risk for osteoporosis. The study found no signifi cant correlation of the estrogen level and periodontal status.…”

Section: Discussionmentioning

confidence: 65%

Effect of subgingivally delivered simvastatin in postmenopausal women with chronic periodontitis: A randomized controlled trial

Gaekwad¹,

Gujjari²,

Kumar³

et al. 2015

JCRI

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Background and Objectives:The defi ciency of estrogen at menopause is a contributing factor that increases susceptibility to resorption due to periodontal infl ammation. Statins have been used successfully in postmenopausal osteopenia. Simvastatin has antiinfl ammatory and antiresorptive properties. This study assessed subgingivally delivered 1.2 mg simvastatin in situ gel in postmenopausal women with chronic periodontitis. Materials and Methods: A total of 40 bilateral pockets (≥4 mm) in 20 systemically healthy postmenopausal subjects were randomized as site A and B, which received either the simvastatin in situ gel or placebo gel after scaling and root planing. Site-specifi c indices, probing depth (PD), and clinical attachment level (CAL) were recorded at baseline, 3 and 6 months. The data were analyzed using descriptive statistics, repeated measure ANOVA, paired and independent samples t-test. Results: A statistically signifi cant (P < 0.05) decrease in PD and improved CAL was observed in both groups over 3 and 6 months. The comparisons of clinical parameters showed statistically signifi cant (P < 0.05) improvements in test sites over the control sites. Conclusion: Simvastatin in situ gel showed improvements in clinical parameters and prolonged anti-infl ammatory eff ects. The results encourage the use of simvastatin in situ gel for the predictable treatment of chronic periodontitis in postmenopausal women.

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Section: Discussionmentioning

confidence: 65%

Effect of subgingivally delivered simvastatin in postmenopausal women with chronic periodontitis: A randomized controlled trial

Gaekwad¹,

Gujjari²,

Kumar³

et al. 2015

JCRI

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“…28 In randomized clinical trials, locally administered simvastatin significantly improved the clinical outcomes of scaling and root planing for treating mandibular buccal Class II defects, and in patients with chronic periodontitis, even when they were smokers or with type II diabetes. [29][30][31] The aim of this study was to prepare novel PLGAlovastatin-chitosan-tetracycline nanoparticles for the local delivery and controlled release of tetracycline and lovastatin. The cytotoxicity, alkaline phosphatase (ALP) activity, and antibacterial activity were evaluated.…”

Section: Introductionmentioning

confidence: 99%

“…45 They can be used as an effective adjunctive treatment in addition to scaling and root planing. Pradeep et al 29,30 designed a biodegradable controlled-release gel containing simvastatin and observed significant probing depth reduction, clinical attachment level gain, and radiographic bone fill in chronic periodontitis patients. The same drug delivery device was applied for treating type II diabetes patients with chronic periodontitis and significantly improved the clinical outcomes of scaling and root planing.…”

mentioning

confidence: 99%

Controlled-release of tetracycline and lovastatin by poly(D,L-lactide-co-glycolide acid)-chitosan nanoparticles enhances periodontal regeneration in dogs

Lee

Wang

et al. 2016

IJN

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Chronic periodontitis is characterized by inflammation of periodontal tissues, leading to bone resorption and tooth loss. The goal of treatment is to regenerate periodontal tissues including bone and cementum lost as a consequence of disease. The local delivery of tetracycline was proven to be effective in controlling localized periodontal infection without apparent side effects. Previous studies suggested that lovastatin has a significant role in new bone formation; however, the local delivery of lovastatin might enhance its therapeutic effects. A number of local delivery devices have been developed recently, including poly( d , l -lactide-co-glycolide acid) (PLGA) nanoparticles. The aim of this study was to develop a local delivery device, PLGA-lovastatin-chitosan-tetracycline nanoparticles, which allows the sequential release of tetracycline and lovastatin to effectively control local infection and promote bone regeneration in periodontitis. The size and microstructure of nanoparticles were examined by transmission electron microscopy, Nanoparticle Size Analyzer, and Fourier transform infrared spectroscopy. The release of tetracycline and lovastatin was quantified using a UV-Vis spectrophotometer. Furthermore, the cytotoxic effect and alkaline phosphatase activity of the nanoparticles in osteoblast cell cultures as well as antibacterial activity against periodontal pathogens were investigated. Finally, the bone regeneration potential of PLGA nanoparticles in three-walled defects in beagle dogs was investigated. The results indicated that PLGA-lovastatin-chitosan-tetracycline nanoparticles showed good biocompatibility, antibacterial activity, and increased alkaline phosphatase activity. The volumetric analysis from micro-CT revealed significantly increased new bone formation in defects filled with nanoparticles in dogs. This novel local delivery device might be useful as an adjunctive treatment in periodontal regenerative therapy.

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“…Attempts to treat furcation lesions have led to therapies ranging from nonsurgical periodontal therapy, such as scaling and root planning , to surgical flap debridement, root resection, hemi section, regenerative therapy and attempts with tissue engineering [5].…”

Section: Introductionmentioning

confidence: 99%

“…These include the use of bone substitutes and guided tissue regeneration (GTR) using membrane techniques [5,6].…”

Section: Introductionmentioning

confidence: 99%

Quantitative Analysis of Interradicular Bone Regeneration after Use of Modified Perforated Collagen Membrane versus Occlusive Membrane in the Management of Grade II Furcation Defects in Dogs

2016

IJSR

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Aim of the work:the aim of this study is to find out the changes in the percentage of the bone surface area in the regenerating interradicular bone which take place in association with using occlusive or modified perforated collagen membranes in management of grade II furcation defects in dogs. Materials and Methods: A total number of four adult clinically healthy mongrel dogs were included in the current study. Sixteen grade II critical-sized furcation defects were surgically createdin lower premolars. In all four dogs, defects on the right quadrants were managed by ß-Tricalcium phosphate (ß-TCP) bone graft and occlusive collagen membrane and defects on the left quadrants were managed by ß-TCP bone graft and modified perforated collagen membrane. Results and conclusions: The obtained data revealed that modified perforated membrane had a positive better role in the regenerating of interradicular bone as revealed by significantly greater value of mean percentage of bone surface area which has taken place in association with it. (P < 0.05)

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Clinical Efficacy of Subgingivally Delivered 1.2‐mg Simvastatin in the Treatment of Individuals With Class II Furcation Defects: A Randomized Controlled Clinical Trial

Abstract: Locally delivered SMV provides a comfortable and flexible method to improve clinical parameters and also to enhance bone formation.

Cited by 68 publications

References 33 publications

Effect of subgingivally delivered simvastatin in postmenopausal women with chronic periodontitis: A randomized controlled trial

Effect of subgingivally delivered simvastatin in postmenopausal women with chronic periodontitis: A randomized controlled trial

Controlled-release of tetracycline and lovastatin by poly(D,L-lactide-co-glycolide acid)-chitosan nanoparticles enhances periodontal regeneration in dogs

Quantitative Analysis of Interradicular Bone Regeneration after Use of Modified Perforated Collagen Membrane versus Occlusive Membrane in the Management of Grade II Furcation Defects in Dogs

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