Clinical Efficacy of Lentinan on Neoplastic Diseases

Taguchi, Tetsuo; Furue, H; Kimura, Tadashi; Kondo, Tatsuhei; Hattori, Takao; Ogawa, Norio

doi:10.1007/978-1-4757-1410-4_15

Cited by 47 publications

(25 citation statements)

References 2 publications

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“…These in vivo effects were observed after parenteral injection of the polysaccharides but not confirmed in the S. pneumoniae model after oral administration. Because AbM [9,10], similarly to b-glucans [22,23], has antitumour effects, and b-glucans also have anti-infection effects [20,24,25], the aims of the present study were to examine whether AbM extract protects against systemic S. pneumoniae infection in a mouse model and to examine the effect of a water extract of AbM administered orally against infections with the moderately virulent S. pneumoniae serotype 6B. End points were peripheral bacteraemia and survival rate of the animals.…”

Section: Introductionmentioning

confidence: 99%

An Extract of the Mushroom Agaricus blazei Murill Administered Orally Protects Against Systemic Streptococcus pneumoniae Infection in Mice

Bernardshaw¹,

Johnson²,

Hetland

2005

Scand J Immunol

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The aim was to investigate the antibacterial effect of the biologically active and edible mushroom Agaricus blazei Murill (AbM). A water extract of AbM or PBS control was administered orally before or with challenge to NIH/OlaHsd mice, experimentally infected intraperitoneally with the moderately virulent Streptococcus pneumoniae serotype 6B. End points were bacteraemia and survival rate. The AbM extract, protected against systemic S. pneumoniae 6B infection in the mice. It was most effective when given 24 h before inoculation but did also have protective effects when given together with challenge compared with control. The lack of antibiotic effect on pneumococci in vitro and increased levels of cytokines MIP-2 and TNF-a in the serum of mice receiving AbM extract, indicated that the protective effect of AbM was due to the involvement of the native immune system. This is the first report of anti-infection effects of AbM in vivo. Our results suggest that AbM extract may be useful as additional prophylactic and possibly therapeutic treatment against bacterial and possibly other infections in humans.

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Section: Introductionmentioning

confidence: 99%

An Extract of the Mushroom Agaricus blazei Murill Administered Orally Protects Against Systemic Streptococcus pneumoniae Infection in Mice

Bernardshaw¹,

Johnson²,

Hetland

2005

Scand J Immunol

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“…Numerous investigations in animals and humans have failed to define their exact mechanism of action. ␤ -glucans have been shown to activate neutrophils (8,9), macrophages (10,11), and natural killer (NK) 1 cells (12)(13)(14) to express potent tumoricidal activity, and the existence of a specific membrane receptor for ␤ -glucan to mediate these responses was proposed 10 yr ago (15). With the identification of CR3 (Mac-1, CD11b/CD18, or ␣ M ␤ 2 -integrin) as the leukocyte membrane receptor for ␤ -glucans (16), it should now be possible to determine the cellular basis for their action and to design more rational approaches for their use in tumor immunotherapy.…”

Section: Introductionmentioning

confidence: 99%

Soluble beta-glucan polysaccharide binding to the lectin site of neutrophil or natural killer cell complement receptor type 3 (CD11b/CD18) generates a primed state of the receptor capable of mediating cytotoxicity of iC3b-opsonized target cells.

Větvička

Thornton²,

Ross³

1996

J. Clin. Invest.

357

292

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When phagocyte CR3 binds to iC3b on bacteria or yeast, phagocytosis and degranulation are triggered because of simultaneous recognition of iC3b via a CD11b I-domain binding site and specific microbial polysaccharides via a lectin site located COOH-terminal to the I-domain. By contrast, when phagocyte or natural killer (NK) cell CR3 adheres to iC3b on erythrocytes or tumor cells that lack CR3-binding membrane polysaccharides, neither lysis nor cytotoxicity are stimulated. This investigation showed that soluble CR3-specific polysaccharides such as ␤ -glucan induced a primed state of CR3 that could trigger killing of iC3b-target cells that were otherwise resistant to cytotoxicity. Anti-CR3 added before sugars prevented priming, whereas anti-CR3 added after sugars blocked primed CR3 attachment to iC3b-targets. Polysaccharide priming required tyrosine kinase(s) and a magnesium-dependent conformational change of the I-domain that exposed the CBRM1/5 activation epitope. Unlike LPS or cytokines, polysaccharides did not up-regulate neutrophil CR3 expression nor expose the mAb 24 reporter epitope representing the high affinity ICAM-1-binding state. The current data apparently explain the mechanism of tumoricidal ␤ -glucans used for immunotherapy. These polysaccharides function through binding to phagocyte or NK cell CR3, priming the receptor for cytotoxicity of neoplastic tissues that are frequently targeted with iC3b and sparing normal tissues that lack iC3b. ( J. Clin. Invest. 1996. 98:50-61.)

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“…β-Glucans are also important dietary substances: they lower the plasma cholesterol level, enhance the hematopoietic response, and possess antitumor and immunomodulating properties [4][5][6]. In Japan, lentinan extracted from Lentinus edodes [7] and sonifilan (SPG) extracted from Schizophyllum commune [8] have been clinically used in cancer therapy.…”

Section: Introductionmentioning

confidence: 99%

A highly branched 1,3-β-d-glucan extracted from Aureobasidium pullulans induces cytokine production in DBA/2 mouse-derived splenocytes

Tada

Yoshikawa

Kuge³

et al. 2009

International Immunopharmacology

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Clinical Efficacy of Lentinan on Neoplastic Diseases

Cited by 47 publications

References 2 publications

An Extract of the Mushroom Agaricus blazei Murill Administered Orally Protects Against Systemic Streptococcus pneumoniae Infection in Mice

An Extract of the Mushroom Agaricus blazei Murill Administered Orally Protects Against Systemic Streptococcus pneumoniae Infection in Mice

Soluble beta-glucan polysaccharide binding to the lectin site of neutrophil or natural killer cell complement receptor type 3 (CD11b/CD18) generates a primed state of the receptor capable of mediating cytotoxicity of iC3b-opsonized target cells.

A highly branched 1,3-β-d-glucan extracted from Aureobasidium pullulans induces cytokine production in DBA/2 mouse-derived splenocytes

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