Clinical Efficacy of External Application Containing Betula platyphyllae Cortex, Viticis Fructus, Agrimoniae herba in Atopic Dermatitis

Abstract

Objectives : The aim of this study is to examine the effect of external application containing herbal extracts (Betula platyphyllae Cortex, Viticis Fructus, Agrimoniae herba) to patients with atopic dermatitis.Methods : Twenty patients (experiment group) were treated with the external application containing herbal extracts (Betula platyphyllae Cortex, Viticis Fructus, Agrimoniae herba) and other twenty patients (control group) were treated with normal external application that doesn't contain herbal extracts for 2weeks. We observed comparisons between experiment and control group after 1week, 2weeks. Degrees of severity of atopic dermatitis were measured by SCORAD index (Scoring of Atopic Dermatitis Index). Statistical significance was achieved if the probability was less than 5% (p<0.05).Results : 1. After 1week of external application treatment, SCORAD Index in experiment group was significantly decreased comparing with control group , which is a marginally significant result between two groups. But after 2weeks the experiment group showed no statistically significant result. 2. After 1week of external application treatment, Intensity Criteria (Erythema, Edema/papulation, Total) in experiment group was significantly decreased comparing with control group, which is a statistically significant result between two groups. But after 2weeks the experiment group showed no statistically significant result.

Inhibitory Effect of A grimonia Pilosa Leaf Extract on the UV-Induced Photoaging-Related Ion Channel, ORAI1, and the Enzymes Tyrosinase and Elastase

“…), lessen wrinkles (Yoon et al . ), as well as alleviate atopic dermatitis (Hong and Jung ) when applied topically, and leaf extract has been previously used in cosmetic products. However, little is known concerning the precise biological mechanisms of these effects.…”

“…Although skin aging is influenced by several factors, such as genetics, hormonal changes, metabolic processes and environmental exposure, solar UV radiation in particular is a considerably important contributor to this process (Jenkins 2002;Farage et al 2008Farage et al , 2013. A. pilosa leaves are known to accelerate skin lightening (Kim et al 2011a,b) and wound healing (Hou et al 2014), lessen wrinkles (Yoon et al 2012), as well as alleviate atopic dermatitis (Hong and Jung 2014) when applied topically, and leaf extract has been previously used in cosmetic products. However, little is known concerning the precise biological mechanisms of these effects.…”

“…), changes in pigmentation (Kim et al . ,b) and atopic dermatitis (Hong and Jung ). However, details of the mechanisms involved have not been fully elucidated.…”

“…Chemical studies have shown that these extracts contain flavonoids (Xu et al 2005;Jung and Park 2007), terpenoids Xie et al 2013) and steroids (Wu et al 2012). Recently, it has also been reported that the external application of extracts effectively treats dermatological problems, such as dermal wounds (Hou et al 2014), wrinkles (Yoon et al 2012), changes in pigmentation (Kim et al 2011a,b) and atopic dermatitis (Hong and Jung 2014). However, details of the mechanisms involved have not been fully elucidated.…”

Evaluation of clinical trial of atopic dermatitis by a topical cream containing the extracts from photosynthetic bacteria, Rhodobacter sphaeroides

“…In addition, adverse affects to some external application products are emerging. Therefore, recent studies have mainly been conducted using products for external application containing oriental medicinal extracts with natural materials that enhance moisturizing effects as therapeutic agents for atopic dermatitis (Hong and Jung 2014). Although clinical effects from extracts from various natural products used as atopic dermatitis treatment materials have been demonstrated, no clear solution has been presented until now.…”