Clinical efficacy of basic fibroblast growth factor (bFGF) for diabetic ulcer

Impaired wound healing results from the dysfunction of the Akt/mTOR pathway in diabetic rats

“…The results indicate that GM-CSF accelerates the process of reepithelialization, increases the formation of granulation tissue with very high cellularity and microvessel density, promotes myofibroblasts proliferation and collagen synthesis, and increases production of growth factors VEGF, bFGF, and TGF-b1, significantly ameliorating growth factor deficiency in diabetic wounds. In accordance with these reports [8,13,27,39], our results also demonstrated that GM-CSF accelerates and improves diabetic wound healing, leading to optimal wound repair.…”

“…At present, growth factors holds the greatest potential to change the situation of diabetic wound treatment [6,[9][10][11][39][40][41]. In diabetic wounds, a dramatic reduction in the levels of growth factors, such as GM-CSF [8,27], impedes repair and regeneration [6,9,11,[39][40][41][42][43][44][45].…”

Wound dressings composed of copper-doped borate bioactive glass microfibers stimulate angiogenesis and heal full-thickness skin defects in a rodent model

“…A variety of approaches have been developed to enhance angiogenesis by bioengineered constructs, including the incorporation of angiogenic factors such as vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF) and platelet-derived growth factor (PDGF) [26e28]. However, the use of growth factors typically suffers from disadvantages such as high cost, potential adverse biological effects when used in supra-physiological doses [29e31] and loss of bioactivity [32,33].…”

Collagen-Gelatin Scaffold Impregnated with bFGF Accelerates Palatal Wound Healing of Palatal Mucosa in Dogs

“…In Japan, human recombinant bFGF in spray form has been widely used for chronic refractory skin ulcers and deep wounds with exposed bone [7,8]. It has also been shown that a single local administration of bFGF promoted the angiogenesis and growth of granulation tissue in full-thickness defects of the skin and palatal mucosa [9,10]; however, the main disadvantage of bFGF for clinical applications is its too short half-life in vivo.…”