Clinical Efficacy and Safety of Shensong Yangxin Capsule-Amiodarone Combination on Heart Failure Complicated by Ventricular Arrhythmia: A Meta-Analysis of Randomized Controlled Trials

Cao, Xinfu; Zhou, Mingxue; Liu, Hongxu; Chen, Xiufen; Li, Xiang; Jia, Si-Han

doi:10.3389/fphar.2021.613922

Cited by 8 publications

(4 citation statements)

References 35 publications

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“…These lines of evidence suggest that NGR1 may improve DCM through TGF-β/Smad2/3 and AKT/Nrf2 signaling pathways. Shensong Yangxin capsule (SSYX) is a TCM prescription widely used to treat arrhythmia and has been used clinically for many years ( Cao et al, 2021 ; Ma et al, 2023 ). Shen et al (2014) found that SSYX significantly reduced the heart weight/body weight ratio of fat emulsion + STZ-induced diabetic rats and improved the degree of cardiac dysfunction, myocardial fibrosis, and collagen deposition.…”

Section: Signaling Pathways In Tcm Intervening the Pathological Progr...mentioning

confidence: 99%

The signaling pathways of selected traditional Chinese medicine prescriptions and their metabolites in the treatment of diabetic cardiomyopathy: a review

Li,

Liu,

Liu

et al. 2024

Front. Pharmacol.

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Diabetic cardiomyopathy (DCM) is a myocardial-specific microvascular disease caused by diabetes that affects the structure and function of the heart and is considered to be the leading cause of morbidity and death in patients with diabetes. Currently, there is no specific treatment or preventive drug for DCM, and there is an urgent need to develop new drugs to treat DCM. Traditional Chinese medicine (TCM) has rich experience in the treatment of DCM, and its characteristics of multi-target, multi-pathway, multi-component, and few side effects can effectively deal with the complexity and long-term nature of DCM. Growing evidence suggests that myocardial fibrosis, inflammation, oxidative stress, apoptosis, cardiac hypertrophy, and advanced glycation end product deposition were the main pathologic mechanisms of DCM. According to the pathological mechanism of DCM, this study revealed the potential of metabolites and prescriptions in TCM against DCM from the perspective of signaling pathways. The results showed that TGF-β/Smad, NF-κB, PI3K/AKT, Nrf2, AMPK, NLRP3, and Wnt/β-catenin signaling pathways were the key signaling pathways for TCM treatment of DCM. The aim of this study was to summarize and update the signaling pathways for TCM treatment of DCM, to screen potential targets for drug candidates against DCM, and to provide new ideas and more experimental evidence for the clinical use of TCM treatment of DCM.

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Section: Signaling Pathways In Tcm Intervening the Pathological Progr...mentioning

confidence: 99%

The signaling pathways of selected traditional Chinese medicine prescriptions and their metabolites in the treatment of diabetic cardiomyopathy: a review

Li,

Liu,

Liu

et al. 2024

Front. Pharmacol.

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“…Previous multicenter clinical studies showed that SSYX capsule has a significant effect on the treatment of heart failure (HF) complicated by ventricular arrhythmia ( Liu et al, 2014 ; Wang X. et al, 2017 ; Cao et al, 2021 ). SSYX capsules have also been demonstrated to be effective in the treatment of paroxysmal AF ( Jiang et al, 2022 ).…”

Section: Translation In Modern Medicinementioning

confidence: 99%

Integrating Evidence of the Traditional Chinese Medicine Collateral Disease Theory in Prevention and Treatment of Cardiovascular Continuum

et al. 2022

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Cardiovascular disease has become a major public health problem. The concept of “cardiovascular continuum” refers to the continuous process from the risk factors that lead to arteriosclerosis, vulnerable plaque rupture, myocardial infarction, arrhythmia, heart failure, and death. These characteristics of etiology and progressive development coincide with the idea of “preventing disease” in traditional Chinese medicine (TCM), which corresponds to the process of systemic intervention. With the update of the understanding via translational medicine, this article reviews the current evidence of the TCM collateral disease theory set prescriptions in both mechanical and clinical aspects, which could lead to the development of new therapeutic strategies for prevention and treatment.

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“…SSYX is a kind of Chinese patent medicine, widely using in the treatment of arrhythmia in China 11 . It composed of ingredients are Ginseng Radix et Rhizoma, Ophiopogon japonicus, Cornus officinalis, Salvia miltiorrhiza, Semen Ziziphi Spinosae (parched), Herba Taxilli, Radix Paeoniae Rubra, Eupolyphaga Seu Steleophaga, Gan Song, Coptidis Rhizoma, Fructus Schisandrae Chinensis and Os Draconis.…”

Section: Introductionmentioning

confidence: 99%

Efficacy, safety, and economy of shensongyangxin capsules for the treatment of coronary heart disease arrhythmia: a meta-analysis of randomized controlled trials

Ma,

Li,

et al. 2023

Annals of Medicine &Amp; Surgery

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Background: Shensong Yangxin Capsules (SSYX) is a proprietary Chinese medicine commonly, used in the treatment of arrhythmia. In recent years, a flurry of randomized controlled trials of SSYX was reported in the treatment of Coronary heart disease arrhythmia in China. However, these experiments have not been systematically evaluated by economics. The purpose of this study was to assess the efficacy, safety, and economy of the SSYX in the treatment of arrhythmia in patients with coronary heart disease. Methods: With “Shensong Yangxin Capsules” “Coronary Heart Disease” “Coronary Atherosclerotic Heart Disease”and “Arrhythmia” as the subject words, the relevant journals and conference papers were searched manually in China National Knowledge Infrastructure (CNKI), Wanfang Database , VIP, PubMed, Web Of Science, CBM, Embase and The Cochrane Library. The literature of randomized controlled trials of SSYX in the treatment of coronary heart disease arrhythmia was searched until November 2022. All data were analyzed using RevMan 5.3 Sotware and combined with cost-effectiveness for economic evaluation. Results: Twenty randomized controlled trials were included in this study, with a total of 2011 cases. The meta-analysis showed that the therapeutic effect of SSYX-metoprolol is superior to that of metoprolol alone. SSYX is superior to amiodarone in improving the total clinical effective rate, reducing the incidence of adverse reactions, and reducing the junction premature beats. There was no significant difference between the SSYX and amiodarone in the curative effect of ECG, ventricular premature complexes, and atrial premature beats. The results of pharmacoeconomics show that SSYX has a cost-effectiveness advantage in treating coronary heart disease arrhythmia. Single-factor sensitivity analysis also confirmed the stability of the results. In summary, SSYX has a curative effect, safety, and economy in treating coronary heart disease arrhythmia.

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Clinical Efficacy and Safety of Shensong Yangxin Capsule-Amiodarone Combination on Heart Failure Complicated by Ventricular Arrhythmia: A Meta-Analysis of Randomized Controlled Trials

Cited by 8 publications

References 35 publications

The signaling pathways of selected traditional Chinese medicine prescriptions and their metabolites in the treatment of diabetic cardiomyopathy: a review

The signaling pathways of selected traditional Chinese medicine prescriptions and their metabolites in the treatment of diabetic cardiomyopathy: a review

Integrating Evidence of the Traditional Chinese Medicine Collateral Disease Theory in Prevention and Treatment of Cardiovascular Continuum

Efficacy, safety, and economy of shensongyangxin capsules for the treatment of coronary heart disease arrhythmia: a meta-analysis of randomized controlled trials

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