Clinical efficacy and safety of intravenous ferric carboxymaltose treatment of pediatric restless legs syndrome and periodic limb movement disorder

DelRosso, Lourdes M.; Ferri, Raffaele; Chen, Maida L.; Kapoor, Vidhi; Allen, Richard P.; Mogavero, Maria Paola; Picchietti, Daniel L.

doi:10.1016/j.sleep.2021.08.030

Cited by 23 publications

(8 citation statements)

References 30 publications

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“…Laass et al9 reported mild and spontaneously resolving reactions due to administration error during FCM infusion in 3 of 72 children 0 to 18 years old with gastrointestinal pathologies, such as ulcerative colitis and Crohn disease. Similarly, mild side effects were observed by DelRosso et al14 in 14% of children 2.3 to 17 years of age with restless legs syndrome or periodic limb movement disorder during single-dose FCM treatment. Some authors reported that they did not observed any side effects in children under 14 years of age 15.…”

Section: Discussionsupporting

confidence: 62%

Intravenous Iron Therapy for Children With Iron Deficiency Anemia

Orhan¹,

Büyükavcı²

2022

Journal of Pediatric Hematology/Oncology

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Iron deficiency anemia in children is a public health problem. Although oral iron treatment is the first choice, common side effects and compliance problems can cause the treatment to be interrupted. This study retrospectively evaluated children treated with intravenous (IV) iron sucrose or ferric carboxymaltose (FCM) and compared the treatment processes and efficacy. The demographic characteristics and treatment details of the 44 children with iron deficiency anemia were retrospectively evaluated. Iron sucrose was administered to 25 patients and FCM was administered to 19 patients. The IV iron infusion was applied to 64% of the patients because of unresponsiveness to oral treatment, 25% of the patients because of compliance problems, and 11% of the patients because of severe anemia. IV iron therapy increased hemoglobin, mean corpuscular volume, mean corpuscular hemoglobin, red-cell distribution width, and serum ferritin levels and decreased platelet count. The mean number of infusions per patient in the FCM group was lower, and the total treatment time was shorter. In conclusion, IV iron sucrose or FCM can be used in children with nonadherence to oral therapy and severe anemia in addition to specific indications.

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Section: Discussionsupporting

confidence: 62%

Intravenous Iron Therapy for Children With Iron Deficiency Anemia

Orhan¹,

Büyükavcı²

2022

Journal of Pediatric Hematology/Oncology

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“…In a cross-sectional study of menstruating women, ferritin concentrations of ≤50μg/L and lower were associated with RLS [ 68 ]. A retrospective review in children with RLS and periodic limb movement disorder demonstrated that oral iron supplementation for individuals with ferritin values of <50 ng/ml had a sustained improvement in the periodic limb movement of sleep index for over 2 y [ 69 ].…”

Section: Adolescents Affected By Idmentioning

confidence: 99%

Nutritional Strategies for Managing Iron Deficiency in Adolescents: Approaches to a Challenging but Common Problem

Cohen,

Powers

2024

Advances in Nutrition

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“…Similarly, the IV ferric carboxymaltose (FCM) in 39 patients, 29 with RLS and 10 with PLMD, who either did not tolerate or respond to oral iron supplementation determined an increase in ferritin (from 14.6 ± 7.01 µg/L to 112.4 ± 65.86 µg/L) and in serum iron levels, total iron binding capacity and transferrin levels. Only 14.3% of patients reported adverse effects that were described as mild, mainly gastrointestinal disturbances [24]. The same group [21] conducted an additional retrospective study to compare oral ferrous sulphate (FS) and IV FCM efficacy in pediatric restless sleep disorder (RSD): 15 children received 325 mg as tablets or 3 mg/kg/day as solution of oral iron, and 15 received 15 mg/kg (750 mg maximum) of IV FCM as a single infusion.…”

Section: Iron and Rls/plmdmentioning

confidence: 99%

The Role of Supplements and Over-the-Counter Products to Improve Sleep in Children: A Systematic Review

Innocenti

Lentini

Rapacchietta

et al. 2023

IJMS

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The sleep–wake cycle is a complex multifactorial process involving several neurotransmitters, including acetylcholine, norepinephrine, serotonin, histamine, dopamine, orexin and GABA, that can be, in turn, regulated by different nutrients involved in their metabolic pathways. Although good sleep quality in children has been proven to be a key factor for optimal cognitive, physical and psychological development, a significant and ever-increasing percentage of the pediatric population suffers from sleep disorders. In children, behavioral interventions along with supplements are recommended as the first line treatment. This systematic review was conducted, according to the PRISMA guidelines, with the purpose of assessing the principal nutrients involved in the pathways of sleep-regulating neurotransmitters in children and adolescents. Our focus was the utilization of over the counter (OTC) products, specifically iron, hydroxytryptophan, theanine and antihistamines in the management of different pediatric sleep disorders with the intention of providing a practical guide for the clinician.

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Clinical efficacy and safety of intravenous ferric carboxymaltose treatment of pediatric restless legs syndrome and periodic limb movement disorder

Cited by 23 publications

References 30 publications

Intravenous Iron Therapy for Children With Iron Deficiency Anemia

Intravenous Iron Therapy for Children With Iron Deficiency Anemia

Nutritional Strategies for Managing Iron Deficiency in Adolescents: Approaches to a Challenging but Common Problem

The Role of Supplements and Over-the-Counter Products to Improve Sleep in Children: A Systematic Review

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