Intravenous Iron Therapy for Children With Iron Deficiency Anemia

Abstract

Iron deficiency anemia in children is a public health problem. Although oral iron treatment is the first choice, common side effects and compliance problems can cause the treatment to be interrupted. This study retrospectively evaluated children treated with intravenous (IV) iron sucrose or ferric carboxymaltose (FCM) and compared the treatment processes and efficacy. The demographic characteristics and treatment details of the 44 children with iron deficiency anemia were retrospectively evaluated. Iron sucrose was administered to 25 patients and FCM was administered to 19 patients. The IV iron infusion was applied to 64% of the patients because of unresponsiveness to oral treatment, 25% of the patients because of compliance problems, and 11% of the patients because of severe anemia. IV iron therapy increased hemoglobin, mean corpuscular volume, mean corpuscular hemoglobin, red-cell distribution width, and serum ferritin levels and decreased platelet count. The mean number of infusions per patient in the FCM group was lower, and the total treatment time was shorter. In conclusion, IV iron sucrose or FCM can be used in children with nonadherence to oral therapy and severe anemia in addition to specific indications.

Preparation, Biological Activities, and Application of Plant Polysaccharide Iron Complexes: A Review

“…Therefore, it is crucial for maintaining physical health to DOI: 10.1002/star.202300145 intake sufficient iron. [5] Presently, the method for people to supplement iron is to take some oral iron supplements such as first-generation and second-generation inorganic iron supplements including ferrous sulfate, ferrous gluconate, ferrous fumarate, and ferrous succinate, etc. [6] However, iron supplements may cause a series of gastrointestinal side effects such as constipation, abdominal pain, nausea, and vomiting in clinical practice.…”