Clinical efficacy and safety of antifungal drugs for the treatment of Candida parapsilosis infections: a systematic review and network meta-analysis

Qin, Jielin; Shan, Zhiming; Jiang, Lingzhi; Zhang, Qingxian

doi:10.1099/jmm.0.001434

Cited by 7 publications

(5 citation statements)

References 29 publications

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“…Data regarding the activity of echinocandins against C. orthopsilosis are still limited and contradictory. So far, the results of antifungal susceptibility testing to echinocandins, if available, have not been commonly implemented into clinical practice, due to the lack of a clear relationship between the in vitro determined MIC value and the clinical outcome [ 44 , 46 ]. The authors of this study postulate that as long as C. orthopsilosis and its antifungal susceptibility data are not included in the epidemiology of CBSI, it will not be possible to obtain comprehensive data to optimize the proper management of CBSI.…”

Section: Discussionmentioning

confidence: 99%

Molecular Investigation of the Fatal Bloodstream Candida orthopsilosis Infection Case following Gastrectomy

Mnichowska-Polanowska

Adamowicz

Wojciechowska‐Koszko

et al. 2023

IJMS

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Candida orthopsilosis represents a closely related cryptic genospecies of Candida parapsilosis complex-misidentified in routine diagnostic assays. This is emerging in settings where central venous catheters, invasive medical interventions, and echinocandin treatments are most likely to be used. A 59-year-old, non-neutropenic male patient, was admitted to an intensive care unit (ICU) due to respiratory distress syndrome, following a partial gastrectomy. As a result of duodenal stump leakage, re-laparotomy was required, abdominal drains were provided and central line catheters were exchanged. Multiple isolates of Candida orthopsilosis drawn from consecutive blood cultures were identified, despite ongoing echinocandin therapy and confirmed in vitro echinocandins susceptibility of the isolated strain. Species identification was verified via ITS region sequencing. Herein, we report the well-documented—per clinical data and relevant laboratory diagnosis—first case of a bloodstream infection caused by Candida orthopsilosis in Poland.

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Section: Discussionmentioning

confidence: 99%

Molecular Investigation of the Fatal Bloodstream Candida orthopsilosis Infection Case following Gastrectomy

Mnichowska-Polanowska

Adamowicz

Wojciechowska‐Koszko

et al. 2023

IJMS

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“…The substitution Asp 4 →Lys in ocellatin‐3N increased the molecular charge at pH 7 from +2 to +4 while maintaining the integrity of the predicted α‐helical domain (Table 1) and so, as expected, resulted in a marked increase in antimicrobial potency against all microorganisms tested (Table 2). The effects on growth inhibition of B. megaterium , a Gram‐positive bacterium implicated in rare cases of endocarditis following bacteremia, 33 P. aeruginosa , a Gram‐negative bacterium strongly implicated in pulmonary infections among immunocompromised and hospitalized patients, 34 and C. parapsilosis , a major emerging yeast pathogen causing severe infections in neonates and patients in intensive care units, 35 are particularly pronounced. The high potency of [D4K]ocellatin‐3N against A. baumannii and P. aeruginosa was also encouraging as the World Health Organization has described antibiotic resistance among these pathogens as ‘critical’.…”

Section: Discussionmentioning

confidence: 99%

Antimicrobial, cytotoxic, and insulin‐releasing activities of the amphibian host‐defense peptide ocellatin‐3N and its L‐lysine‐substituted analogs

Conlon

Hunter

Attoub

et al. 2022

Journal of Peptide Science

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The host-defense peptide ocellatin-3N (GIFDVLKNLAKGVITSLAS.NH 2 ), first isolated from the Caribbean frog Leptodactylus nesiotus, inhibited growth of clinically relevant Gram-positive and Gram-negative bacteria as well as a strain of the major emerging yeast pathogen Candida parapsilosis. Increasing cationicity while maintaining amphipathicity by the substitution Asp 4 !Lys increased potency against the microorganisms by between 4-and 16-fold (MIC ≤3 μM) compared with the naturally occurring peptide. The substitution Ala 18 !Lys and the double substitution Asp 4 !Lys and Ala 18 !Lys had less effects on potency. The [D4K] analog also showed 2.5-to 4-fold greater cytotoxic potency against non-small-cell lung adenocarcinoma A549 cells, breast adenocarcinoma MDA-MB-231 cells, and colorectal adenocarcinoma HT-29 cells (LC 50 values in the range of 12-20 μM) compared with ocellatin-3N but was less hemolytic to mouse erythrocytes. However, the peptide showed no selectivity for tumor-derived cells [LC 50 = 20 μM for human umbilical vein endothelial cells (HUVECs)]. Ocellatin-3N and [D4K]ocellatin-3N stimulated the release of insulin from BRIN-BD11 clonal β-cells at concentrations ≥1 nM, and [A18K]ocellatin-3N, at concentrations ≥0.1 nM. No peptide stimulated the release of lactate dehydrogenase at concentrations up to 3 μM, indicating that plasma membrane integrity had been preserved. The three peptides produced an increase in intracellular [Ca 2+ ] in BRIN-BD11 cells when incubated at a concentration of 1 μM. In view of its high insulinotropic potency and relatively low hemolytic activity, the [A18K] ocellatin analog may represent a template for the design of agents with therapeutic potential for the treatment of patients with type 2 diabetes.

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“…Despite C. albicans being the main etiologic agent in this category, the growing increases in species such as C. parapsilosis with strains resistant to antifungal drugs has changed this epidemiological profile [12]. The particular importance of the increased incidence of C. parapsislosis is due to its ability to form biofilms on intravascular devices and prosthetic materials, gastrointestinal colonization and transmission by colonized hands of health professionals, making it difficult to control [13].…”

Section: Discussionmentioning

confidence: 99%

Candida parapsilosis culture extracts: in vitro, antagonistic action against Candida albicans, Candida auris and Candida parapsilosis

Lemes

Nascentes

Regasini

et al. 2022

BJCR

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Fungal infections caused by Candida species has increased significantly in recent years. Additionally, resistance to conventional therapy is an aggravating factor causing high morbidity and mortality, especially in immunocompromised patients or those undergoing treatment with another antimicrobials. During the infection process, Candida species produces metabolites which can self-regulate population density, in addition to controlling several virulence factors and exerting action on other microorganisms. In view of this fact, the present study evaluated the in vitro antifungal activity of the pure culture extract of Candida parapsilosis against Candida albicans, Candida auris and Candida parapsilosis. Fungal culture extracts of C. parapsilosis were prepared in Sabouraud Dextrose Broth, extracted with ethyl acetate and dried in a rotary evaporator. Subsequently, tests were performed to determine the minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MFC). The antifungal activity of the extracts against Candida species showed values of MIC ranging between 500 - 2000 µg/mL and a MFC range of 1414 µg/mL - 2000 µg/mL. Future investigations for the identification and composition of this fungal culture extract will provide insights about metabolites are present and involved in the antifungal activity shown here, contributing for the future to new therapeutic approaches in the control of infections caused by Candida.

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Clinical efficacy and safety of antifungal drugs for the treatment of Candida parapsilosis infections: a systematic review and network meta-analysis

Cited by 7 publications

References 29 publications

Molecular Investigation of the Fatal Bloodstream Candida orthopsilosis Infection Case following Gastrectomy

Molecular Investigation of the Fatal Bloodstream Candida orthopsilosis Infection Case following Gastrectomy

Antimicrobial, cytotoxic, and insulin‐releasing activities of the amphibian host‐defense peptide ocellatin‐3N and its L‐lysine‐substituted analogs

Candida parapsilosis culture extracts: in vitro, antagonistic action against Candida albicans, Candida auris and Candida parapsilosis

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