Clinical effects of sleep fragmentation versus sleep deprivation

Bonnet, Michael H.; Arand, Donna L.

doi:10.1053/smrv.2001.0245

Cited by 350 publications

(236 citation statements)

References 70 publications

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“…25,26 Our findings show a VNS induced improvement of sleep quality with increased SWS, a tendency to decrease in sleep fragmentation (see stage shifts, Table 3) and a tendency towards reduction in daytime sleep, probably contributing to improved wellbeing. [27][28][29] In our study the improvement in QOL was significant for the whole group (p=0.03). There was concordance in direction of changes between enhanced SWS and QOL in 9 of 15 children.…”

Section: Discussionsupporting

confidence: 53%

Beneficial effects on sleep of vagus nerve stimulation in children with therapy resistant epilepsy

Hallböök

Lundgren

Köhler

et al. 2005

European Journal of Paediatric Neurology

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Section: Discussionsupporting

confidence: 53%

Beneficial effects on sleep of vagus nerve stimulation in children with therapy resistant epilepsy

Hallböök

Lundgren

Köhler

et al. 2005

European Journal of Paediatric Neurology

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“…Sleep fragmentation is also part of upper airway resistance syndrome and results in excessive daytime sleepiness (Black et al, 2000;Bonnet and Arand, 2003;Guilleminault et al, 1993). Chronic sleep loss also occurs in nightshift workers, rotating shift workers, and on-call workers, and is compounded by circadian rhythm disturbances (Humphrey et al, 1994;Akerstedt, 1987, 1988a) reviewed in (Akerstedt, 1988).…”

Section: Sleep Lossmentioning

confidence: 99%

“…Sleep fragmentation (frequent brief disruptions at regular intervals) similarly increases subjective daytime sleepiness, impairs mood, and decreases MSLT times even when total sleep times are normal based on conventional visual sleep scoring methods, and even if the arousals are subclinical (i.e. based on EEG changes alone) (Bonnet and Arand, 2003;Cote et al, 2003;Kingshott et al, 2000;Levine et al, 1987;Martin et al, 1996;Stepanski, 2002). Sleep interruptions may be as infrequent as every 10 min yet still produce an effect on MSLT scores (Stepanski, 2002).…”

Section: Sleep Lossmentioning

confidence: 99%

Vigilance, alertness, or sustained attention: physiological basis and measurement

Oken

Salinsky

Elsas

2006

Clinical Neurophysiology

660

463

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Vigilance is a term with varied definitions but the most common usage is sustained attention or tonic alertness. This usage of vigilance implies both the degree of arousal on the sleep-wake axis and the level of cognitive performance. There are many interacting neural and neurotransmitter systems that affect vigilance. Most studies of vigilance have relied on states where the sleep-wake state is altered, e.g. drowsiness, sleep-deprivation, and CNS-active drugs, but there are factors ranging from psychophysics to motivation that may impact vigilance. While EEG is the most commonly studied physiologic measure of vigilance, various measures of eye movement and of autonomic nervous system activity have also been used. This review paper discusses the underlying neural basis of vigilance and its assessment using physiologic tools. Since, assessment of vigilance requires assessment of cognitive function this aspect is also discussed.

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“…It has been shown that sleep fragmentation leads to increased objective sleepiness and decreased psychomotor performance, even when total sleep was normal (Bonnet and Arand, 2003). In order to perform this analysis, we averaged the duration of sleep bouts in each rat.…”

Section: Staging and Measures Of Sleep-wake Cyclesmentioning

confidence: 99%

Total Sleep Deprivation Decreases Immobility In The Forced-Swim Test

Rodríguez

Kim

Poland

2004

Neuropsychopharmacol

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Sleep deprivation can exert antidepressant effects in humans in less than 24 h, making it the fastest acting antidepressant treatment. However, it is rarely used clinically because the effect disappears once the subject goes back to sleep. An understanding of the neurobiological mechanisms underlying the antidepressant effect of sleep deprivation should help to develop new rapidly acting antidepressant strategies. In the present report, an animal model of depression (the forced-swim test) was used to determine whether the effects of total sleep deprivation parallel those obtained with antidepressant drugs. Using the disk-over-water method, rats deprived of sleep for 24 h exhibited increased swimming behavior when compared to cage control rats, mimicking the effects of serotonergic antidepressants. After 48 h, sleep-deprived rats exhibited increased swimming when compared to both cage control and stimulus control rats, demonstrating that the effect is due to sleep deprivation per se, and not to extraneous factors inherent in the sleep deprivation protocol (such as stress and movement). We believe that this paradigm can be used to study the neurobiological mechanisms of rapid antidepressant effects induced by sleep deprivation.

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Clinical effects of sleep fragmentation versus sleep deprivation

Cited by 350 publications

References 70 publications

Beneficial effects on sleep of vagus nerve stimulation in children with therapy resistant epilepsy

Beneficial effects on sleep of vagus nerve stimulation in children with therapy resistant epilepsy

Vigilance, alertness, or sustained attention: physiological basis and measurement

Total Sleep Deprivation Decreases Immobility In The Forced-Swim Test

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