Clinical effects of platelet-rich fibrin (PRF) following surgical extraction of lower third molar

Al-Hamed, Faez Saleh; Tawfik, Mohamed A.; Abdelfadil, Ehab

doi:10.1016/j.sjdr.2016.05.002

Cited by 42 publications

(39 citation statements)

References 24 publications

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“…However, there are several clinical trials to support the positive effect of autologous materials in soft tissue healing and bone regeneration and increasing bone density in comparison with other types of grafts. The results of the present study are in accordance with Al-Hamed, et al (10) , Kumar et al (24) and Bilginaylar and Uyanik results (25) . These researches showed a significant effect of L-PRF on postoperative swelling and pain perception as it showed less pain in comparison with HA.…”

Section: Discussionsupporting

confidence: 92%

“…In view of the biological characteristics, PRF is safe, effective and more economical as a graft material for alveolar sites. (7)(8)(9)(10)(11) However, the use of platelet-rich fibrin (PRF) as graft material has increased in recent years. The beneficial growth factors from platelets were first described by Ross et al (12) Choukroun (13) defined PRF as a fibrin matrix in which platelet cytokines and cells are trapped and could serve as a graft material.…”

Section: Introductionmentioning

confidence: 99%

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Efficacy of Autologous Leucocyte-Platelet-rich Fibrin (L-PRF) versus Hydroxyapatite as a Graft Material for Socket Healing after Surgical Extraction of Impacted Mandibular Third Molars: A Comparative Clinical and Radiographic study

Rashed

Elsharkawy

Zaied

et al. 2019

Egyptian Dental Journal

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OBJECTIVE: The purpose of this study was to compare the efficacy of Leucocyte-platelet-rich fibrin (L-PRF), and hydroxyapatite (HA) for reduction of pain and swelling, the incidence of dry socket, soft tissue healing, and bone regeneration after surgical removal of impacted mandibular third molar in human patients. Patients and Methods: Thirty-six patients (20 males and 16 females) requiring extraction of mandibular third molars were randomly grouped as L-PRF, HA, and Control-treated. All the procedures were done on an outpatient basis without any complication such as lip numbness. The patients were assessed for postoperative pain, swelling and maximal inter-incisal distance on the 1st, 3rd and 7th postoperative days. Exposed bony socket wall (dry socket), as well as soft tissue healing (healthy granulation tissue Formation), were also assessed at 1st, 3rd, 7th and 14th day of postoperative periods depending on the standard methods. Assessment of daily and total analgesics consumption was done and Radiological assessment of the extraction site was done at 2 and 6 months interval. Results: Pain, swelling, interincisal distance, and soft tissue healing had statistically significant more improvement for L-PRF group compared to HA and control groups. Radiographic assessment showed comparatively lesser bone density values in PRF and control sites at 2 and 6 months than HA site. Conclusion: Our study showed that L-PRF is better graft materials than HA regarding pain, swelling, dry socket, and soft tissue healing post-L-PRF placement in the extraction socket. Bone regeneration is induced quickly by HA as compared to PRF. However, study with a wide scale of clinical cases is very much essential to be more decisive regarding the efficacy of the graft materials.

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Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Efficacy of Autologous Leucocyte-Platelet-rich Fibrin (L-PRF) versus Hydroxyapatite as a Graft Material for Socket Healing after Surgical Extraction of Impacted Mandibular Third Molars: A Comparative Clinical and Radiographic study

Rashed

Elsharkawy

Zaied

et al. 2019

Egyptian Dental Journal

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“…2a and b. A previous study [34] had a high risk of bias in allocation concealment, 3 studies [20, 21, 31] had a high risk of bias in blinding of participants and personnel, and 3 studies [20, 21, 28] had a high risk of bias in blinding of outcome assessment. The quality of the evidence of each result was shown in Table 2.…”

Section: Resultsmentioning

confidence: 99%

Impact of platelet-rich fibrin on mandibular third molar surgery recovery: a systematic review and meta-analysis

Shi

Zhang

et al. 2019

BMC Oral Health

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Background The present study investigated and evaluated the efficacy and safety of platelet-rich fibrin (PRF) in patients during bilateral mandibular third molars extraction by systematic review and meta-analysis. Methods The PubMed, Embase, and Cochrane library databases were retrieved, and the effect of PRF on the healing process of the alveolar socket after surgical extraction of the mandibular third molars was evaluated by meta-analysis. The postoperative pain, swelling, trismus, osteoblastic activity, and soft tissue healing were assessed, and the incidence of alveolar osteitis, weighted mean difference (WMD)/standard mean difference (SMD), the risk ratio (RR), and the 95% confidence interval (CI) were calculated. Results The current results showed that the local application of PRF during lower third molar extraction prevented postoperative complications. Subsequently, the pain (SMD = − 0.53, 95% CI: − 1.02–-0.05, P heterogeneity = 0.001, I 2 = 75.7%) and swelling (WMD = − 0.55, 95% CI: − 1.08–-0.01, P heterogeneity = 0.573, I 2 = 0) were relieved and the incidence of alveolar osteitis was reduced (RR = 0.35, 95% CI: 0.16–0.75, P heterogeneity = 0.597, I 2 = 0%). However, no significant difference was observed in trismus, osteoblastic activity, and soft tissue healing between the PRF and non-PRF groups. Conclusion The current study confirms that PRF only reduces some of the postoperative complications but does not prevent all the postoperative complications. PRF significantly relieved the pain and swelling and reduced the incidence of alveolar osteitis after the extraction of an impacted lower third molar. Electronic supplementary material The online version of this article (10.1186/s12903-019-0824-3) contains supplementary material, which is available to authorized users.

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“…The purpose of the current study was to Hamed et al (24) which showed that PRF significantly reduced postoperative pain and analgesic intake following surgical removal of impacted third molars for few postoperative days. This should be considered with caution because it is based on the subjective visual analogue scale, sensation of pain, and response to analgesics, which differ from person to another.…”

Section: Discussionmentioning

confidence: 97%

Effects of Local Application of Platelet Rich Fibrin on Postoperative Sequelae after Surgical Removal of Impacted Lower Third Molars.

Marouf¹,

Rejab²

2020

RDENTJ

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Aims: The goals of this research was to evaluate the effects of Platelet Rich Fibrin (PRF) in reducing postsurgical complications as pain, swelling, and trismus after surgical extraction of impacted lower third molars. Materials and Methods: A total of 44 patients who fulfilled the inclusion criteria were chosen to take part in this research. Postoperative pain was assessed using a numerical rating scale (NRS). Facial swelling was measured by a modification of tape measure method. To assess trismus, the maximal interincisal mouth opening was measured by using a digital caliper scale (electronic vernier). Results: In the Platelet Rich Fibrin PRF group; the results showed a significant difference of levels of pain experienced (NRS) in the 1 st postoperative day in comparison to the control group. In regard to post-operative swelling; a significant decrease in the 3 rd postoperative day was observed in comparison to the control group. With regard to trismus; no significant differences between groups regarding interincisal mouth opening was noticed. Conclusions: The application of PRF reduces the severity of the immediate postoperative sequelaes.

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Clinical effects of platelet-rich fibrin (PRF) following surgical extraction of lower third molar

Cited by 42 publications

References 24 publications

Efficacy of Autologous Leucocyte-Platelet-rich Fibrin (L-PRF) versus Hydroxyapatite as a Graft Material for Socket Healing after Surgical Extraction of Impacted Mandibular Third Molars: A Comparative Clinical and Radiographic study

Efficacy of Autologous Leucocyte-Platelet-rich Fibrin (L-PRF) versus Hydroxyapatite as a Graft Material for Socket Healing after Surgical Extraction of Impacted Mandibular Third Molars: A Comparative Clinical and Radiographic study

Impact of platelet-rich fibrin on mandibular third molar surgery recovery: a systematic review and meta-analysis

Effects of Local Application of Platelet Rich Fibrin on Postoperative Sequelae after Surgical Removal of Impacted Lower Third Molars.

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