Clinical effect of cerebrovascular atherosclerosis on cognition in Alzheimer’s disease

Kim, Tae−Won; Song, In‐Uk; Jeong, Du-Shin; Lee, Kwang Soo

doi:10.1016/j.archger.2015.11.009

Cited by 11 publications

(10 citation statements)

References 17 publications

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“…35 Other studies have followed up patients with cognitive impairment and noted cognitive decline in those with ICAS. 10,11 Results of these studies suggest that the association between ICAS and cognitive impairment noted in our study is causative.…”

Section: Discussionmentioning

confidence: 50%

“…[1][2][3][4] There is growing evidence that intracranial atherosclerosis is associated with clinical and pathologic manifestations of Alzheimer disease (AD). [5][6][7][8][9][10][11][12] Experimental [13][14][15][16][17][18] and clinical studies 13,[19][20][21] support the hypothesis that cerebral ischemia contributes to AD pathology. Intracranial atherosclerotic stenosis (ICAS) may also be associated with cognitive impairment and AD by causing cerebral hypoperfusion.…”

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confidence: 67%

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Cognitive impairment and intracranial atherosclerotic stenosis in general population

et al. 2018

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Section: Discussionmentioning

confidence: 50%

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confidence: 67%

Cognitive impairment and intracranial atherosclerotic stenosis in general population

et al. 2018

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“…Fatty acid intake and the circulating lipid profile might affect the development of cognitive impairment by way of the influence of fatty acids on atherosclerosis and thrombosis [ 18 , 19 ]. In the present study, we compared the lipid-rich food intake and erythrocyte lipid profile between MCI and control subjects.…”

Section: Discussionmentioning

confidence: 99%

The Erythrocyte Fatty Acid Profile and Cognitive Function in Old Chinese Adults

Yuan

Zhang

et al. 2016

Nutrients

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Objective: To explore the relationship between the erythrocyte fatty acid profile and cognition in elderly Chinese adults. Methods: 60 mild cognitive impairment (MCI) subjects and 60 age- and gender-matched control adults (aged 55 years and above) were involved in this cross-sectional study. Cognitive function was measured by using the Montreal Cognitive Assessment (MoCA) test. Information regarding the demographic characteristics and lifestyle of the participants was collected with a questionnaire. A semi-quantified food frequency questionnaire (FFQ) method was used for dietary assessment. The erythrocytes fatty acid profile was measured. Results: The MCI subjects had a lower education level than the control subjects (p < 0.05). Compared with control subjects, MCI subjects had higher daily poultry intake and lower fish intake (p < 0.05). Erythrocyte fatty acid profile of the MCI subjects was characterized as lower erythrocyte proportions of 20:4 n-6, 20:5 n-3, and total n-3 fatty acids compared with control subjects (p < 0.05). An association of erythrocyte proportions of 18:0, 22:0, total SFA, 18:2 n-6, 24:4 n-6 fatty acids, docosahexaenoic acid (DHA), and total n-6 PUFAs with cognition in elderly Chinese adults was detected. Conclusion: The erythrocyte fatty acid profile was related to cognitionin the elderly. Lower erythrocyte unsaturated fatty acid and higher saturated fatty acid proportions might predict cognitive function decline in elderly Chinese adults.

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“…al found more widespread intracranial atherosclerosis in AD patients versus nondemented patients 44 . Cognitive dysfunction was also found to be exacerbated in AD patients with cerebral atherosclerosis compared to non-atherosclerotic AD patients, regardless of intracranial or extracranial localization 45 . Furthermore, the Nun Study of Aging and Alzheimer’s Disease indicated that patients with multiple brain infarctions have lower cognitive function and higher prevalence of dementia 46, 47 .…”

Section: Introductionmentioning

confidence: 90%

Getting to the Heart of Alzheimer Disease

Tublin

Adelstein

Monte

et al. 2019

Circulation Research

146

104

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In a somewhat narrow diagnostic lens, Alzheimer’s Disease (AD) has been considered a brain specific disease characterized by the presence of β-Amyloid plaques and tau neural fibrillary tangles and neural inflammation; these pathologies lead to neuronal death and consequently clinical symptoms such as memory loss, confusion, and impaired cognitive function. However, for decades researchers have noticed a link between various cardiovascular abnormalities and AD - such as heart failure (HF), coronary artery disease (CAD), atrial fibrillation (AF), and vasculopathy. A considerable volume of work has pointed at this head to heart connection, focusing mainly on associations between cerebral hypoperfusion and neuronal degradation. However, new evidence of a possible systemic or metastatic profile to AD calls for further analysis of this connection. β amyloid aggregations - biochemically and structurally akin to those found in the typical AD pathology - are now known to be present in the hearts of individuals with idiopathic dilated cardiomyopathy (iDCM) as well as the hearts of patients with AD. These findings suggest a potential systemic profile of proteinopathies, and a new hypothesis for the link between peripheral and central symptoms of HF and AD. Herein, we provide an overview of the cardiovascular links to Alzheimer’s disease.

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Clinical effect of cerebrovascular atherosclerosis on cognition in Alzheimer’s disease

Cited by 11 publications

References 17 publications

Cognitive impairment and intracranial atherosclerotic stenosis in general population

Cognitive impairment and intracranial atherosclerotic stenosis in general population

The Erythrocyte Fatty Acid Profile and Cognitive Function in Old Chinese Adults

Getting to the Heart of Alzheimer Disease

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