The Erythrocyte Fatty Acid Profile and Cognitive Function in Old Chinese Adults

Yuan, Linhong; Zhang, Jie; Ma, Weiwei; Cai, Can; Huang, Xiaochen; Xiao, Rong

doi:10.3390/nu8070385

Cited by 18 publications

(11 citation statements)

References 40 publications

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“…The study identified individuals with higher baseline erythrocyte membrane DHA levels had higher their brain volumes approximately 8 years later. Similar beneficial effects of DHA (erythrocyte membrane DHA levels) on brain among elderly / adults are reported in other studies as well [35,36]. These studies provide evidences for positive association between erythrocyte membrane DHA levels and brain volume, and possibly a beneficial role with regards to cognition.…”

Section: Pottala Et Al (2014) Documented Positive Association Betweensupporting

confidence: 86%

DHA Manuscript

Balachandar¹,

Soundararajan²,

Bagepally³

2019

Preprint

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Purpose: To investigate the role of DHA supplementation in preventing Age Related Cognitive Decline (ARCD) in cognitive domains by conducting systematic review and meta-analysis.Methods: Relevant clinical trials were systematically searched at Medline-Pubmed, Scopus, Cochrane, ProQuest and Embase databases since inception to June 2018. The PRISMA guidelines were adhered for data abstraction, quality assessment and validity of included randomized control trails. Study details such as participant characteristics, DHA supplementation and cognitive function outcome measures i.e. memory, attention, working memory and executive function scores, were extracted and performed meta-analysis according to Cochrane guidelines. Additional meta-regression and subgroup analysis was performed to detect confounding variables and sensitivity of results respectively.Results: Ten studies including 2327 elderly individuals were part of the final results. Study exhibited minimal or no pooled incremental effects on memory (0.22, 95%CI=-0.17 to 0.61, I2=94.36%, p<0.001), attention (0.1, 95%CI=-0.04 to 0.25, I2=32.25%, p=0.18), working memory (0.01, 95%CI=-0.10 to 0.12, I2=0%, p=0.89) and executive function (0.03, 95%CI=-0.05 to 0.11, I2=78.48%, p<0.001) among DHA supplemented group. While results from standard mean difference between groups on memory (0.08, 95%CI=-0.12 to 0.28, I2=76.82%, p<0.001), attention (0.04, 95%CI=-0.09 to 0.23, I2=42.63%, p=0.11), working memory (-0.08, 95%CI=-0.26 to 0.10, I2=37.57%, p=0.17) and executive function (0.17, 95%CI=-0.01 to 0.36, I2=78.48%, p<0.001). Results remained unaffected in multiple sensitivity and sub-group analyses.Conclusions: Current evidences don’t support the role of DHA supplementation, in preventing / retarding ARCD of memory, executive function, attention and working memory.Protocol registered at PROSPERO (ID: PROSPERO 2018 CRD42018099401).

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Section: Pottala Et Al (2014) Documented Positive Association Betweensupporting

confidence: 86%

DHA Manuscript

Balachandar¹,

Soundararajan²,

Bagepally³

2019

Preprint

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“…It is also attractive the fact that membranes are made of fatty acids, which are in their turn components of the nutrition, with the essential omega-6 and omega-3 polyunsaturated fatty acids (PUFA) especially important for the correct child growth. Moreover, fatty acids in membrane phospholipids are evaluated in many diseases, including neurological ones, finding out that RBC membranes give precious indications on omega-3 and other fatty acids that influence brain structures, functions and behavior 26 , 27 , 28 , 29 . Membrane fatty acid analysis in our ASD cohort evidenced a significantly different DHA level (ANOVA test, P value = 0.0344).…”

Section: Discussionmentioning

confidence: 99%

High predictive values of RBC membrane-based diagnostics by biophotonics in an integrated approach for Autism Spectrum Disorders

Giacometti

Ferreri

Sansone

et al. 2017

Sci Rep

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Membranes attract attention in medicine, concerning lipidome composition and fatty acid correlation with neurological diseases. Hyperspectral dark field microscopy (HDFM), a biophotonic imaging using reflectance spectra, provides accurate characterization of healthy adult RBC identifying a library of 8 spectral end-members. Here we report hyperspectral RBC imaging in children affected by Autism Spectrum Disorder (ASD) (n = 21) compared to healthy age-matched subjects (n = 20), investigating if statistically significant differences in their HDFM spectra exist, that can comprehensively map a membrane impairment involved in disease. A significant difference concerning one end-member (spectrum 4) was found (P value = 0.0021). A thorough statistical treatment evidenced: i) diagnostic performance by the receiving operators curve (ROC) analysis, with cut-offs and very high predictive values (P value = 0.0008) of spectrum 4 for identifying disease; ii) significant correlations of spectrum 4 with clinical parameters and with the RBC membrane deficit of the omega-3 docosahexaenoic acid (DHA) in ASD patients; iii) by principal component analysis, very high affinity values of spectrum 4 to the factor that combines behavioural parameters and the variable “cc” discriminating cases and controls. These results foresee the use of biophotonic methodologies in ASD diagnostic panels combining with molecular elements for a correct neuronal growth.

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“…These include biomarkers associated with cell growth (insulin-like growth factor binding protein), pancreatic function (pancreatic polypeptide), stress (cortisol), 1-carbon metabolism (homocysteine), antioxidant function (superoxide dismutase), and kidney function (b-2 microglobulin) (13)(14)(15). Other studies showed strong associations of single FAs or combinations of specific SFAs, MUFAs, PUFAs, and v-3 FAs with MCI (16)(17)(18)(19). Such biomarkers, when combined with other risk factors such as age, sex, and APOE genotype may provide a stronger predictive potential for identifying those with an increased probability of MCI and AD.…”

Section: Current Status Of Knowledgementioning

confidence: 93%

Vitamins Associated with Brain Aging, Mild Cognitive Impairment, and Alzheimer Disease: Biomarkers, Epidemiological and Experimental Evidence, Plausible Mechanisms, and Knowledge Gaps

Fenech

2017

Advances in Nutrition

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The key to preventing brain aging, mild cognitive impairment (MCI), and Alzheimer disease (AD) via vitamin intake is first to understand molecular mechanisms, then to deduce relevant biomarkers, and subsequently to test the level of evidence for the impact of vitamins in the relevant pathways and their modulation of dementia risk. This narrative review infers information on mechanisms from gene and metabolic defects associated with MCI and AD, and assesses the role of vitamins using recent results from animal and human studies. Current evidence suggests that all known vitamins and some "quasi-vitamins" are involved as cofactors or influence ≥1 of the 6 key sets of pathways or pathologies associated with MCI or AD, relating to ) 1-carbon metabolism,) DNA damage and repair, ) mitochondrial function and glucose metabolism,) lipid and phospholipid metabolism and myelination, ) neurotransmitter synthesis and synaptogenesis, and) amyloidosis and Tau protein phosphorylation. The contemporary level of evidence for each of the vitamins varies considerably, but it is notable that B vitamins are involved as cofactors in all of the core pathways or pathologies and, together with vitamins C and E, are consistently associated with a protective role against dementia. Outcomes from recent studies indicate that the efficacy and safety of supplementation with vitamins to prevent MCI and the early stages of AD will most likely depend on ) which pathways are defective,) which vitamins are deficient and could correct the relevant metabolic defects, and ) the modulating impact of nutrient-nutrient and nutrient-genotype interaction. More focus on a precision nutrition approach is required to realize the full potential of vitamin therapy in preventing dementia and to avoid causing harm.

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The Erythrocyte Fatty Acid Profile and Cognitive Function in Old Chinese Adults

Cited by 18 publications

References 40 publications

DHA Manuscript

DHA Manuscript

High predictive values of RBC membrane-based diagnostics by biophotonics in an integrated approach for Autism Spectrum Disorders

Vitamins Associated with Brain Aging, Mild Cognitive Impairment, and Alzheimer Disease: Biomarkers, Epidemiological and Experimental Evidence, Plausible Mechanisms, and Knowledge Gaps

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