Clinical differentiation of acute cutaneous graft-versus-host disease from drug hypersensitivity reactions

Byun, Hee Jin; Yang, Jong In; Kim, Byoung Kook; Cho, Kwang Hyun

doi:10.1016/j.jaad.2010.07.042

Cited by 48 publications

(47 citation statements)

References 14 publications

(12 reference statements)

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“…The differential diagnosis includes drug reactions, viral exanthems, engraftment syndrome and effects of chemotherapy or radiation. The distribution of the rash over the face, palms and soles is more common in aGvHD compared to drug rashes and the association with hyperbilirubinaemia and diarrhoea also makes GvHD more likely (Byun et al, 2011). Cutaneous biopsy may be important, particularly in the absence of the classical constellation of symptoms.…”

Section: Diagnosismentioning

confidence: 99%

Diagnosis and management of acute graft‐versus‐host disease

Dignan¹,

et al. 2012

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SummaryA joint working group established by the Haemato-oncology subgroup of the British Committee for Standards in Haematology (BCSH) and the British Society for Bone Marrow Transplantation (BSBMT) has reviewed the available literature and made recommendations for the diagnosis and management of acute graft-versus-host disease. This guideline includes recommendations for the diagnosis and grading of acute graft-versus-host disease as well as primary treatment and options for patients with steroid-refractory disease. The goal of treatment should be effective control of graft-versushost disease while minimizing risk of toxicity and relapse.

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Section: Diagnosismentioning

confidence: 99%

Diagnosis and management of acute graft‐versus‐host disease

Dignan¹,

et al. 2012

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“…When patients develop morbilliform skin eruptions within the first 100 days following hematopoietic cell transplantation, dermatologists are often consulted to differentiate acute cutaneous GVHD from other forms of dermatitis, such as drug hypersensitivity reaction or viral exanthema, which frequently arise in this setting. Although certain clinical features or concomitant evidence of extracutaneous GVHD can be useful in supporting a diagnosis of GVHD, the cutaneous presentation is typically non‐specific. Early studies have documented microscopic features associated with acute GVHD .…”

mentioning

confidence: 99%

Acute cutaneous graft‐vs.‐host disease compared to drug hypersensitivity reaction with vacuolar interface changes: a blinded study of microscopic and immunohistochemical features

et al. 2014

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“…GVHD is a complex disease. Its clinical assessment is made especially challenging by the subjectivity of clinician evaluations and attribution to competing diagnoses . We established a dedicated GVHD team to ensure that consistent standards for GVHD diagnosis are applied across all patients.…”

Section: Discussionmentioning

confidence: 99%

Establishing a standardized system for review and adjudication of chronic graft‐vs‐host disease data in accordance with the National Institutes Consensus criteria

et al. 2019

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Graft‐vs‐host Disease (GVHD) is a frequent complication following allogeneic stem cell transplantation (allo‐HCT). The National Institute of Health consensus group established new guidelines for the evaluation of chronic GVHD. However, GVHD assessment remains challenging due to its complexity and requirement for laborious evaluation. We, therefore, established a standardized approach for the assessment of chronic GVHD in accordance with the NIH consensus criteria (NCC) guidelines. At a single institution, all allograft recipients were evaluated for GVHD within the first‐year post allo‐HCT following a three‐step workflow (real‐time assessment, consensus review, and documentation). A GVHD adjudication committee was created and a dynamic electronic GVHD data capture form was developed guiding the clinician through a comprehensive review of systems following the NCC guidelines. We found that the assessment and reporting of GVHD reached 100% compliance. The establishment of an institutional GVHD adjudication committee enabled standardized assessment of GVHD. Our workflow can be adopted by other centers to create a similar framework for dedicated GVHD evaluation.

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Clinical differentiation of acute cutaneous graft-versus-host disease from drug hypersensitivity reactions

Cited by 48 publications

References 14 publications

Diagnosis and management of acute graft‐versus‐host disease

Diagnosis and management of acute graft‐versus‐host disease

Acute cutaneous graft‐vs.‐host disease compared to drug hypersensitivity reaction with vacuolar interface changes: a blinded study of microscopic and immunohistochemical features

Establishing a standardized system for review and adjudication of chronic graft‐vs‐host disease data in accordance with the National Institutes Consensus criteria

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