Clinical Determinants of Incremental Shuttle Walk Test in Adults with Bronchiectasis

Yildiz, Şulenur; Inal-Ince, Deni̇z; Çalık-Kütükçü, Ebru; Vardar-Yağlı, Naciye; Sağlam, Melda; Çöplü, Lütfi

doi:10.1007/s00408-018-0094-x

Cited by 11 publications

(14 citation statements)

References 32 publications

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“…In the present study, the distance walked among bronchiectasis patients, both male and females, was also reduced compared to the healthy controls. In addition, total distance walked by female patients was significantly lower than that observed in the male patients, as also previously shown [ 53 ]. These results imply that exercise tolerance is an important parameter that should be included in the management of patients with bronchiectasis in clinics.…”

Section: Discussionsupporting

confidence: 85%

Respiratory and Peripheral Muscle Weakness and Body Composition Abnormalities in Non-Cystic Fibrosis Bronchiectasis Patients: Gender Differences

et al. 2022

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As demonstrated in COPD, bronchiectasis patients may experience respiratory and peripheral muscle dysfunction. We hypothesized that respiratory and peripheral (upper and lower limbs) muscle function and nutritional status may be more significantly altered in female than in males for identical age and disease severity. In mild-to-moderate bronchiectasis patients (n = 150, 114 females) and 37 controls (n = 37, 21 females), radiological extension, maximal inspiratory and expiratory pressures (MIP and MEP), sniff nasal inspiratory pressure (SNIP), hand grip and quadriceps muscle strengths, body composition, and blood analytical biomarkers were explored. Compared to the controls, in all bronchiectasis patients (males and females), BMI, fat-free mass index (FFMI), fat tissue, upper and lower limb muscle strength, and respiratory muscle strength significantly declined, and FFMI, fat tissue, and quadriceps muscle function were significantly lower in female than male patients. In patients with mild-to-moderate bronchiectasis, respiratory and peripheral muscle function is significantly impaired and only partly related to lung disease status. Quadriceps muscle strength was particularly weakened in the female patients and was negatively associated with their exercise tolerance. Muscle weakness should be therapeutically targeted in bronchiectasis patients. Body composition and peripheral muscle function determination should be part of the comprehensive clinical assessment of these patients.

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Section: Discussionsupporting

confidence: 85%

Respiratory and Peripheral Muscle Weakness and Body Composition Abnormalities in Non-Cystic Fibrosis Bronchiectasis Patients: Gender Differences

et al. 2022

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“…In patients with moderate and severe COPD, the distance covered during the ISWT is significantly associated with pulmonary function parameters, such as vital capacity and airway obstruction (FEV 1 ), as well as health-related quality of life (35). According to Yildiz et al (36), the ISWT distance is significantly associated with FEV 1 (r = 0.65) and FVC (r = 0.54) in adults with bronchiectasis. The 6MWT is considered a submaximal field test aimed to assess functional capacity by measuring distance walked within a controlled duration.…”

Section: Discussionmentioning

confidence: 99%

Desaturation-Distance Ratio During Submaximal and Maximal Exercise Tests and Its Association With Lung Function Parameters in Patients With Lymphangioleiomyomatosis

et al. 2021

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Background: The desaturation–distance ratio (DDR), the ratio of the desaturation area to the distance walked, is a promising, reliable, and simple physiologic tool for functional evaluation in subjects with interstitial lung diseases. Lymphangioleiomyomatosis (LAM) is a rare neoplastic condition frequently associated with exercise impairment. However, DDR has rarely been evaluated in patients with LAM.Objectives: To assess DDR during maximal and submaximal exercises and evaluate whether DDR can be predicted using lung function parameters.Methods: A cross-sectional study was conducted in a cohort of women with LAM. The 6-min walking test (6MWT) and the incremental shuttle walking test (ISWT) were performed, and DDR was obtained from both tests. The functional parameters were assessed at rest using spirometry and body plethysmography. The pulmonary function variables predictive of DDR were also assessed.Results: Forty patients were included in this study. The mean age was 46 ± 10 years. Airway obstruction, reduced DLCO, and air trapping were found in 60, 57, and 15% of patients, respectively. The distance walked and the DDR for the 6MWT and ISWT were, respectively, 517 ± 65 and 443 ± 127 m; and 6.6 (3.8–10.9) and 8.3 (6.2–12.7). FEV1 (airway obstruction) and reduced DLCO and RV/TLC (air trapping) were independent variables predictive of DDR during exercises field tests [DDR6MWT = 18.66–(0.06 × FEV1%pred)–(0.10 × DLCO%pred) + (1.54 × air trapping), Radjust2 = 0.43] and maximal [DDRISWT = 18.84–(0.09 × FEV1%pred)–(0.05 × DLCO%pred) + (3.10 × air trapping), Radjust2 = 0.33].Conclusion: Our results demonstrated that DDR is a useful tool for functional evaluation during maximal and submaximal exercises in patients with LAM, and it can be predicted using airway obstruction, reduced DLCO, and air trapping.

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“…In NCFB, pulmonary function (FVC or FEV 1 ) is just a determinant affecting the ISWT distance, and other independent variables are age, gender, dyspnea perception, muscle strength, disease severity, fatigue, psychosocial factors, and HRQoL [34]. Moreover, the effect of PR is multifactorial, and improvement of exercise tolerance is due to an optimization of the function of body systems, such as reducing respiratory rate and dyspnea, improving skeletal-muscle function, and aerobic efficiency of the muscles [33, 35].…”

Section: Discussion/conclusionmentioning

confidence: 99%

Pulmonary Rehabilitation in Noncystic Fibrosis Bronchiectasis

Ora

Prendi²,

Ritondo

et al. 2021

Respiration

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Background: Current guidelines for the treatment of noncystic fibrosis bronchiectasis (NCFB) recommend pulmonary rehabilitation (PR), but to date, there are few studies that have proven its effectiveness. Objective: The main objective of this study was to examine the effect of PR on pulmonary function tests and exercise capacity. Method: The aim of this study was to systematically review the effects of PR in NCFB on (1) forced expiratory volume in the first second (FEV1) and (2) exercise capacity evaluated by the 6-min walk test (6MWT) and the incremental shuttle walk test (ISWT). This meta-analysis was undertaken according to PRISMA recommendations. Results: This pair-wise meta-analysis included data obtained from studies that enrolled 529 NCFB patients. The FEV1 assessment after PR between the active and control group did not show any significant increase (FEV1 difference 0.084 mL; CI: −0.064, +0.233; p = 0.264), and there was an increasing trend (188 mL; CI: −0 to 0.009, +0.384) at the limits of statistical significance (p = 0.061). Walked distance showed a significant increase in the PR group compared to the control group (ISWT distance difference 070.0 m; CI: 55.2, 84.8; p < 0.001), and this finding was confirmed before and after PR both by the ISWT (68.85 m greater than baseline; CI: 40.52, 97.18; p < 0.001) and by the 6MWT (37.7 m greater than baseline; CI: 20.22, 55.25; p < 0.001). Conclusions: PR improves exercise tolerance in NCFB patients, but it has a modest impact on respiratory function.

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Clinical Determinants of Incremental Shuttle Walk Test in Adults with Bronchiectasis

Cited by 11 publications

References 32 publications

Respiratory and Peripheral Muscle Weakness and Body Composition Abnormalities in Non-Cystic Fibrosis Bronchiectasis Patients: Gender Differences

Respiratory and Peripheral Muscle Weakness and Body Composition Abnormalities in Non-Cystic Fibrosis Bronchiectasis Patients: Gender Differences

Desaturation-Distance Ratio During Submaximal and Maximal Exercise Tests and Its Association With Lung Function Parameters in Patients With Lymphangioleiomyomatosis

Pulmonary Rehabilitation in Noncystic Fibrosis Bronchiectasis

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