Respiratory and Peripheral Muscle Weakness and Body Composition Abnormalities in Non-Cystic Fibrosis Bronchiectasis Patients: Gender Differences

Wang, Xuejie; Balaña-Corberó, Ana; Martínez‐Llorens, Juana; Qin, Long; Xia, Yingchen; Zha, Jianhua; Maiques, José María; Barreiro, Esther

doi:10.3390/biomedicines10020334

Cited by 8 publications

(7 citation statements)

References 77 publications

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“…BMI, serum ALB and PAB were commonly considered as markers for re ecting nutritional status. A previous study demonstrated that a substantial number of patients with bronchiectasis presented with low BMI in comparison to healthy people 21,22 . Bronchiectasis patients also presented with lower BMI and ALB compared with those with other respiratory disorders like COPD, neuromuscular disease, restrictive disorders and mixed respiratory failure 23 .…”

Section: Discussionmentioning

confidence: 98%

The clinical characteristics of non-cystic fibrosis bronchiectasis patients with positive serum tumor markers: a retrospective study

Wang

et al. 2023

Preprint

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Background Serum tumor markers (STM), extensively used for the diagnosis, monitoring and prognostic assessment of tumors, can be increased in some non-malignant lung diseases. To date, there is a paucity of studies regarding the clinical characteristics of non-cystic fibrosis bronchiectasis patients with positive STMs. Objective To investigate the clinical characteristics and risk factors of bronchiectasis with one and multiple positive STMs. Methods The clinical data of 377 bronchiectasis patients was retrospectively collected from January 2017 to December 2019 from Beijing Chaoyang Hospital. Patients were divided into STM positive and STM negative group. According to the number of the positive STMs, the STM positive group was further subdivided into the single STM positive group and the ≥ 2 STMs positive group. The clinical characteristics are described and compared separately and the multivariate logistic regression analysis model was used to investigate the risk factors regarding the positive STMs. Results Patients in the STM positive group were older (P = 0.005), had a longer disease duration (P = 0.026), higher mMRC scores (P = 0.019) and developed higher fever (P = 0.027). Additionally, patients with positive STMs also had lower Albumin/Globulin Ratio (A/G), prealbumin (PAB) (P = 0.016, P = 0.043, respectively) and higher CRP, ESR and Fbg (P = 0.001, P = 0.002 and P < 0.001, respectively). ESR (OR 1.824, 95%CI 1.061–3.137; P = 0.030) and the number of affected lobes (OR 1.388, 95%CI 1.184–1.627; P < 0.001) were independently associated with one and two or more positive STMs in bronchiectasis patients. Conclusion The positive STM is associated with a higher inflammation status and severer radiologic manifestations in bronchiectasis patients.

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Section: Discussionmentioning

confidence: 98%

The clinical characteristics of non-cystic fibrosis bronchiectasis patients with positive serum tumor markers: a retrospective study

Wang

et al. 2023

Preprint

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“…BMI, serum ALB and PAB were commonly considered as markers for reflecting nutritional status. A previous study demonstrated that a substantial number of patients with bronchiectasis presented with low BMI in comparison to healthy people [ 23 , 24 ]. Bronchiectasis patients also presented with lower BMI and ALB compared with those with other respiratory disorders like COPD, neuromuscular disease, restrictive disorders and mixed respiratory failure [ 25 ].…”

Section: Discussionmentioning

confidence: 99%

The clinical characteristics of non-cystic fibrosis bronchiectasis patients with positive serum tumor markers: a retrospective study

Wang,

et al. 2024

BMC Pulm Med

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Background Serum tumor markers (STM), extensively used for the diagnosis, monitoring and prognostic assessment of tumors, can be increased in some non-malignant lung diseases. To date, there is a paucity of studies regarding the clinical characteristics of non-cystic fibrosis bronchiectasis patients with positive STMs. Objective To investigate the clinical characteristics and indicators of bronchiectasis with positive STMs. Methods The clinical data of 377 bronchiectasis patients was retrospectively collected from January 2017 to December 2019 from Beijing Chaoyang Hospital. Patients were divided into the STM negative group, the single STM positive group and the ≥2 STMs positive group according to the number of the positive STMs. The clinical characteristics are described and compared separately. The multivariate logistic regression analysis model was used to investigate the indicators regarding positive STMs. Results Patients in the ≥2 STMs positive group were older (P = 0.015), had higher mMRC scores (P < 0.001) and developed higher fever (P = 0.027). Additionally, these patients also had lower Albumin/Globulin Ratio (A/G), albumin (ALB), prealbumin (PAB) (P < 0.001, P < 0.001, P < 0.001, respectively) and higher CRP, ESR and Fbg (P < 0.001, P < 0.001 and P < 0.001, respectively). Age (OR 1.022, 95%CI 1.003–1.042; P = 0.026) and the number of affected lobes (OR 1.443, 95%CI 1.233–1.690; P < 0.001) were independently associated with one and ≥ 2 positive STMs in bronchiectasis patients. Conclusion The ≥2 positive STMs are associated with a higher inflammation status and severer radiologic manifestations in bronchiectasis patients.

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“…A recent study has reported that bronchiectasis patients have a lower BMI, fat-free mass, upper and lower limb muscle strength, and respiratory muscle strength such as maximal inspiratory pressure and maximal expiratory pressure than healthy controls [28]. Similarly, other studies have shown that peripheral muscle strength, peripheral muscle endurance by a squat test, and respiratory muscle strength are significantly lower in bronchiectasis patients [29, 30] and that respiratory muscle strength is related to peripheral muscle strength [29].…”

Section: Discussionmentioning

confidence: 99%

“…In this study, the lowest sex-specific PMA quartile group was associated with higher severity and mortality, which may explain the low percentage of patients presenting with hemoptysis. Patients with bronchiectasis have lower fat-free mass and muscle strength than healthy controls [28][29][30]. However, the prevalence of sarcopenia in these patients is not clearly known.…”

Section: Mortality In Bronchiectasis Exacerbationmentioning

confidence: 99%

Pectoralis Muscle Area as a Predictor of Mortality in Patients Hospitalized with Bronchiectasis Exacerbation

Seo,

Cha,

Park

et al. 2024

Respiration

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Introduction: Data on factors related to mortality in patients with bronchiectasis exacerbation are insufficient. Computed tomography (CT) can measure the pectoralis muscle area (PMA) and is a useful tool to diagnose sarcopenia. This study aimed to evaluate whether PMA can predict mortality in patients with bronchiectasis exacerbation. Methods: Patients hospitalized due to bronchiectasis exacerbation at a single center were retrospectively divided into survivors and non-survivors based on 1-year mortality. Thereafter, a comparison of the clinical and radiologic characteristics was conducted between the two groups. Results: A total of 66 (14%) patients died at 1 year. In the multivariate analysis, age, BMI <18.4 kg/m2, sex-specific PMA quartile, ≥3 exacerbations in the previous year, serum albumin <3.5 g/dL, cystic bronchiectasis, tuberculosis-destroyed lung, and diabetes mellitus were independent predictors for the 1-year mortality in patients hospitalized with bronchiectasis exacerbation. A lower PMA was associated with a lower overall survival rate in the survival analysis according to sex-specific quartiles of PMA. PMA had the highest area under the curve during assessment of prognostic performance in predicting the 1-year mortality. The lowest sex-specific PMA quartile group exhibited higher disease severity than the highest quartile group. Conclusions: CT-derived PMA was an independent predictor of 1-year mortality in patients hospitalized with bronchiectasis exacerbation. Patients with lower PMA exhibited higher disease severity. These findings suggest that PMA might be a useful marker for providing additional information regarding prognosis of patients with bronchiectasis exacerbation.

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Respiratory and Peripheral Muscle Weakness and Body Composition Abnormalities in Non-Cystic Fibrosis Bronchiectasis Patients: Gender Differences

Cited by 8 publications

References 77 publications

The clinical characteristics of non-cystic fibrosis bronchiectasis patients with positive serum tumor markers: a retrospective study

The clinical characteristics of non-cystic fibrosis bronchiectasis patients with positive serum tumor markers: a retrospective study

The clinical characteristics of non-cystic fibrosis bronchiectasis patients with positive serum tumor markers: a retrospective study

Pectoralis Muscle Area as a Predictor of Mortality in Patients Hospitalized with Bronchiectasis Exacerbation

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