Clinical decision making and application of an active rehabilitation program for a person with the neuromuscular symptoms of Allgrove syndrome: a case report

Adams, Joseph T.; Dpt,; Ncs,

doi:10.1080/09593985.2018.1548049

Cited by 1 publication

(1 citation statement)

References 43 publications

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“…Potential symptoms may be debilitating or life-threatening 12,54. Glucocorticoid supplementation does not seem to affect the development and course of neurologic symptoms,43 however, tailored physical therapy sessions may help improve endurance and balance in patients who experience neuromuscular symptoms 58…”

Section: Neurologymentioning

confidence: 99%

<p>Triple A syndrome (Allgrove syndrome): improving outcomes with a multidisciplinary approach</p>

Flokas¹,

Tomani²,

Agdere³

et al. 2019

PHMT

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Allgrove syndrome or triple A (3A) syndrome is a multisystem disorder which classically involves the triad of esophageal achalasia, alacrima, and adrenal insufficiency due to adrenocorticotropin hormone insensitivity. It follows an autosomal recessive pattern of inheritance and is associated with mutations in the AAAS (achalasia–addisonianism–alacrima syndrome) gene. Since its first description in 1978, the knowledge on clinical and genetic characteristics has been expanding; however, the current literature is limited to case reports and case reviews. Early recognition of the syndrome is challenging, given the rarity of the condition and high phenotypic heterogeneity even among members of kin. The coordination of care for these patients requires a multidisciplinary team of specialists, including endocrinologists, neurologists, gastroenterologists, ophthalmologists, developmental specialists, dentists, geneticists, and surgeons. In this review, we aim to summarize the current recommendations for the diagnosis, management, and follow-up of patients with 3A syndrome.

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