Clinical course and sequelae for tick-borne encephalitis among children in South Moravia (Czech Republic)

Krbková, Lenka; Štroblová, Hana; Bednářová, Jana

doi:10.1007/s00431-014-2401-8

Cited by 36 publications

(30 citation statements)

References 47 publications

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“…In total, 37 clinical studies published between 1975 and 2020 were included [ 3 , 4 , 6 , 7 , 10 , 11 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 ] ( Table 6 ). The distribution of diagnoses showed the frequency of M ranging from 7 to 78%, ME from 13 to 84%, and MEM from 3 to 11%.…”

Section: Resultsmentioning

confidence: 99%

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Clinical Characteristics of Patients with Tick-Borne Encephalitis (TBE): A European Multicentre Study from 2010 to 2017

et al. 2021

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Tick-borne encephalitis (TBE) virus is a major cause of central nervous system infections in endemic countries. Here, we present clinical and laboratory characteristics of a large international cohort of patients with confirmed TBE using a uniform clinical protocol. Patients were recruited in eight centers from six European countries between 2010 and 2017. A detailed description of clinical signs and symptoms was recorded. The obtained information enabled a reliable classification in 553 of 555 patients: 207 (37.3%) had meningitis, 273 (49.2%) meningoencephalitis, 15 (2.7%) meningomyelitis, and 58 (10.5%) meningoencephalomyelitis; 41 (7.4%) patients had a peripheral paresis of extremities, 13 (2.3%) a central paresis of extremities, and 25 (4.5%) had single or multiple cranial nerve palsies. Five (0.9%) patients died during acute illness. Outcome at discharge was recorded in 298 patients. Of 176 (59.1%) patients with incomplete recovery, 80 (27%) displayed persisting symptoms or signs without recovery expectation. This study provides further evidence that TBE is a severe disease with a large proportion of patients with incomplete recovery. We suggest monitoring TBE in endemic European countries using a uniform protocol to record the full clinical spectrum of the disease.

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Section: Resultsmentioning

confidence: 99%

“…Although we observed severe cases, none of the pediatric cases died. A relatively low mortality rate in children and adolescents has been reported before [ 31 , 44 , 45 ]. According to our findings and to the findings of the literature review, no significant decrease in mortality rates during the last decades was found.…”

Section: Discussionmentioning

confidence: 96%

Clinical Characteristics of Patients with Tick-Borne Encephalitis (TBE): A European Multicentre Study from 2010 to 2017

et al. 2021

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“…In children, TBE infection is described as having a mild clinical course. TBE under the age of three years is rare, and the mean age of the meningoencephalitic form of TBE is 14 years [ 10 ]. The reason why childhood TBE is usually less severe than TBE in adults is still not fully understood.…”

Section: Discussionmentioning

confidence: 99%

Tick-Borne Encephalitis in an 8.5-Month-Old Boy Suspected of Febrile Seizures

et al. 2021

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“…Encephalitis can also be caused by autoimmune disorders, but these are beyond the scope of the current review. Infectious encephalitis typically triggers fever, seizures, and focal neurologic deficits (Khatib et al, 2017;Krbková et al, 2015;Sittinger et al, 2002). Diagnosis is similar to that of meningitis, in that it may include a lumbar puncture, neurological and radiological examinations (Tyler & Ropper, 2018).…”

Section: Introductionmentioning

confidence: 99%

Language impairments and CNS infections: a review

2021

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Introduction: Infectious agents such as viruses, bacteria, parasites, fungi, and arthropods can affect the meninges and/or the brain and trigger/relate to difficulties with language tasks. We reviewed the literature on language impairments in people with Central Nervous System (CNS) infections. Aims: To review published reports of CNS infections that trigger/ relate to difficulties with language tasks, to highlight the most commonly infectious agents, and to provide further grounds to study this topic. Methods: PubMed, Medline, Google Scholar, and Web of Science records were examined. Search strings with 70 infection terms and the words aphasia, fluency, language, naming, reading, and writing were used. The reference section and the citations of each study were examined. The type of infection, infectious agent, number of patients, neurological damage, language tests administered, and main findings were noted for each article meeting the inclusion criteria. Results: We found 41 articles published in the last 45 years. Half of the reports were single case (series) and the other half group studies. Infections with 18 agents were detected as triggering/ related to difficulties with language tasks. Bacterial meningitis, Herpes Simplex Encephalitis (HSV), and HIV were most commonly reported. Reports of English-speaking patients were most common (46%) followed by other languages spoken in the Western world. Damage to specific cortico-subcortical areas is indicated in half of the studies. Most reports presented cases with diffuse or focal bilateral damage affecting the frontal or temporal lobes. Discussion and conclusion: The current literature is heterogeneous regarding assessment times and language protocols. There is a tendency towards testing language production and administering tests that assess severe language damage. HSV reports use the most in-depth language protocols, probably because of the specific impairments triggered by this disease due to damage to the temporal lobes. Further work may focus on understanding mild language impairments; less explored brain infections, language domains, and modalities (e.g., written/spoken comprehension); risk factors, and impact of co-occurring conditions; and how CNS ARTICLE HISTORY

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Clinical course and sequelae for tick-borne encephalitis among children in South Moravia (Czech Republic)

Abstract: Tick-borne encephalitis in children has a benign course with minimal sequelae. Meningitis with biphasic course is the prevalent involvement and the duration of IgM antibodies in serum and index of positivity are not decisive for postencephalitic disorders.

Cited by 36 publications

References 47 publications

Clinical Characteristics of Patients with Tick-Borne Encephalitis (TBE): A European Multicentre Study from 2010 to 2017

Clinical Characteristics of Patients with Tick-Borne Encephalitis (TBE): A European Multicentre Study from 2010 to 2017

Tick-Borne Encephalitis in an 8.5-Month-Old Boy Suspected of Febrile Seizures

Language impairments and CNS infections: a review

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