Clinical Correlation between Brain Natriutetic Peptide and Anthracyclin-induced Cardiac Toxicity

Abstract

Purpose: Anthracycline can effectively treat hematologic malignancies, but has significant risk of cardiotoxicity. We measured the clinical correlation between brain natriuretic peptide (BNP) and anthracycline-induced cardiotoxicity.

NT-ProBNP and cardiac troponin I in virulent canine babesiosis

“…Cardiac troponin has been shown to be the most sensitive and specific factor for the prediction of myocardial injury and in humans it can be detected from about 8 hours after the cardiac injury and 10 days thereafter (Collinson et al, 2000;Lee et al, 2008), an ideal time window for clinical canine babesiosis that are usually represent within this time frame after the infection started. In our study approximately 33% of dogs with mild and severe babesiosis had elevated cTnI whereas the number increased to 53% in the complicated group.…”

Serum B-type natriuretic peptide levels as a marker for anthracycline-induced cardiotoxicity

“…Finally, three articles with incomplete data were excluded. The remaining 8 articles met all the inclusion criteria and the studies were, published between 2001 and 2014, with moderate-high study quality (1,(8)(9)(10)(11)(33)(34)(35). Table I shows the basic characteristics of included studies on the BNP serum level.…”

“…Anthracycline agents are effective drugs utilized for a variety of solid and haematological malignancies (1,2). Anthracyclines significantly improve the overall 5-year survival (>80%) in pediatric cancers (3,4).…”

“…In general, the risk of developing AIC is closely linked to the cumulative dose of anthracyclines (8,9). Furthermore, other factors such as age and gender may also contribute to the occurrence of AIC (1). Once patients exhibit symptoms of cardiac failure, reversal of the condition via termination of anthracycline therapy may become impossible (10).…”

“…Thus, it is important to detect AIC as early as possible (9). Multiple studies have demonstrated that B-type natriuretic peptide (BNP), a neurohormone secreted in the cardiac ventricles, reflect left ventricular (LV) end diastolic pressure and pulmonary capillary wedge pressure, and may independently predict AIC (1,11).…”